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6201por Rocha, Sayonarah C., Pessoa, Marco T. C., Neves, Luiza D. R., Alves, Silmara L. G., Silva, Luciana M., Santos, Herica L., Oliveira, Soraya M. F., Taranto, Alex G., Comar, Moacyr, Gomes, Isabella V., Santos, Fabio V., Paixão, Natasha, Quintas, Luis E. M., Noël, François, Pereira, Antonio F., Tessis, Ana C. S. C., Gomes, Natalia L. S., Moreira, Otacilio C., Rincon-Heredia, Ruth, Varotti, Fernando P., Blanco, Gustavo, Villar, Jose A. F. P., Contreras, Rubén G., Barbosa, Leandro A.“…In this study, we added a styrene group to the lactone ring of the cardiotonic steroid digoxin, to obtain 21-benzylidene digoxin (21-BD), and investigated the effects of this synthetic cardiotonic steroid in different cell models. …”
Publicado 2014
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6202por Penthala, Narsimha Reddy, Bommagani, Shobanbabu, Janganati, Venumadhav, Parkin, Sean, Crooks, Peter A.“…The 4-[(Z)-2-cyano-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl group on the parthenolide exocyclic double bond is oriented in a trans position to the lactone ring to form the E isomer. The dihedral angle between the benzene ring of the phenyl moiety and the lactone ring mean plane is 21.93 (4)°.…”
Publicado 2014
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6203“…METHODS: All conizations and CC registered between 2000 and 2014 at the Institute of Pathology at the Cantonal Hospital of Lucerne have been included in our study. …”
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6204por Turner, Richard Myles, Fontana, Vanessa, Bayliss, Mark, Whalley, Sarah, Santoyo Castelazo, Anahi, Pirmohamed, Munir“…Therefore a rapid, selective, sensitive and reproducible multi-analyte HPLC-MS/MS assay for the quantification in human plasma of atorvastatin, its major metabolites 2-hydroxyatorvastatin, atorvastatin lactone and 2-hydroxyatorvastatin lactone, plus bisoprolol and clopidogrel-carboxylic acid has been developed, fully validated, and applied to a large patient study. …”
Publicado 2018
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6205“…The present study evaluated the inducibility of miRNA expression and putative downstream regulation of cytochrome P450s in response to DDT exposure in a time-dependent manner in 91-R and the susceptible Canton-S strain. Specifically, RT-qPCR analysis showed that DDT exposures led to the significant down-regulation (repression) of miR-310-3p, miR-311-3p, miR-312-3p, miR-313-3p, and miR-92a-3p levels in Canton-S. …”
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6206por Malacrida, Sandro, De Lazzari, Federica, Mrakic-Sposta, Simona, Vezzoli, Alessandra, Zordan, Mauro A., Bisaglia, Marco, Menti, Giulio Maria, Meda, Nicola, Frighetto, Giovanni, Bosco, Gerardo, Dal Cappello, Tomas, Strapazzon, Giacomo, Reggiani, Carlo, Gussoni, Maristella, Megighian, Aram“…Indeed, as expected, in normoxia Sod1(n1) are the shortest-lived, while the wild-type strains, despite a longer lifespan, show some differences, with the Canton-S line displaying the lowest mortality rate. …”
Publicado 2022
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6207“…BACKGROUND: Spinosad is a macrolide insecticide with the tetracyclic lactone backbone to which forosamine and tri-o-methylrhamnose are attached. …”
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6208por Chan, Kok-Gan, Tan, Wen-Si, Chang, Chien-Yi, Yin, Wai-Fong, Mumahad Yunos, Nina Yusrina“…Here, we report the draft whole-genome sequence of a freshwater isolate from Malaysia, A. hydrophila strain M062, and its N-acylhomoserine lactone genes are also reported here.…”
Publicado 2015
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6209“…The genome includes genes responsible for acyl-homoserine lactone-mediated quorum sensing, enterobactin, and aerobactin.…”
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6210“…Dr Francesca Ciccarelli (The Francis Crick Institute, UK) and Dr James De Gregori (University of Colorado, USA) interview 3 top scientists in clinical (Dr Charles Swanton, The Francis Crick Institute, UK), molecular (Dr Kornelia Polyak, Dana-Farber Cancer Institute, USA), and evolutionary cancer research (Dr Carlo Maley, Arizona State University, USA) to discuss the current status of knowledge, the challenges, and the opportunities to move the field forward.…”
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6211“…RESULTS: Interactions of N-butyryl-DL-homoserine lactone (C4-HSL), N-(3-oxooctanoyl)-L-homoserine lactone (C8-HSL) and N-(3-oxododecanoyl)-L-homoserine lactone (C12-HSL) with His(6)-OPH dimer active sites in the presence of puromycin and ceftiofur were simulated and studied. …”
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6212“…We discuss the low-energy dynamics of generalized extremal higher membrane black hole solutions of string theory and higher membrane theories following Manton's prescription for multi-soliton solutions. …”
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6213“…Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones. The products participate in facially selective additions from the convex surface, leading to allylic alcohol derivatives.…”
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6214por Sarigaputi, Chanin, Teerawatananond, Thapong, Pengpreecha, Somchai, Muangsin, Nongnuj, Pudhom, Khanitha“…The six-carbocyclic rings (B and C) exhibit a twisted-boat conformation. The lactone ring has a half-chair conformation and the furan ring is planar (r.m.s. deviation = 0.002 Å). …”
Publicado 2010
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6215“…It consists of three cyclohexane rings (A, B and C), a five-membered ring (D) and a six-membered lactone ring (E). The stereochemistry of the ring junctions are A/B cis, B/C trans and C/D cis. …”
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6216por Good, Barbara, Hanrahan, James Patrick, de Waal, Daniel Theodorus, Kinsella, Andrew, Lynch, Ciaran Oliver“…Resistance of nematode populations to macrocyclic lactone was suspected on a small number of farms (11%) but needs to be confirmed. …”
Publicado 2012
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6217“…A gram-scale synthesis of terminally-branched iso-fatty acids (iso-C(12)–C(19)) was developed commencing with methyl undec-10-enoate (methyl undecylenate) (for iso-C(12)–C(14)) or the C(15) and C(16) lactones pentadecanolide (for iso-C(15)–C(17)) and hexadecanolide (for iso-C(18)–C(19)). …”
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6218“…Chiral α,β-unsaturated acylammonium salts are novel dienophiles enabling enantioselective Diels–Alder-lactonization (DAL) organocascades leading to cis- and trans-fused, bicyclic γ- and δ-lactones from readily prepared dienes, commodity acid chlorides, and a chiral isothiourea organocatalyst under mild conditions. …”
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6219“…N-acylated homoserine lactone (AHL) mediated cell-cell communication in bacteria is dependent on the recognition of the cognate signal by its receptor. …”
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6220por Hwang, Sunhee, Mruk, Karen, Rahighi, Simin, Raub, Andrew G., Chen, Che-Hong, Dorn, Lisa E., Horikoshi, Naoki, Wakatsuki, Soichi, Chen, James K., Mochly-Rosen, Daria“…Crystallographic study and mutagenesis analysis identify the structural and functional defect of one common mutant (Canton, R459L). Using high-throughput screening, we subsequently identify AG1, a small molecule that increases the activity of the wild-type, the Canton mutant and several other common G6PD mutants. …”
Publicado 2018
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