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  1. 6241
    “…Our results designate autoinducer-1 lactones as the main targets for a global biocontrol of soft-rot bacteria communications, including those of emerging isolates.…”
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    Quorum Sensing Signaling Molecules Produced by Reference and Emerging Soft-Rot Bacteria (Dickeya and Pectobacterium spp.)
  2. 6242
    “…The high level of resistance to the macrocyclic lactones has encouraged the search for strategies to optimize their potential as antiparasitic agents. …”
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    Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression()
  3. 6243
    “…Quorum sensing (QS) is a mechanism in which Gram negative bacterial pathogens sense their population density through acyl homoserine lactones (AHLs) and regulate the expression of virulence factors. …”
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    Attenuation of Quorum Sensing Regulated Virulence of Pectobacterium carotovorum subsp. carotovorum through an AHL Lactonase Produced by Lysinibacillus sp. Gs50
  4. 6244
    “…Data were extrapolated to the dose per day per 100’000 population stratified by age, gender, and canton. RESULTS: In total, 4’746’942 paracetamol, 2’156’620 NSAIDs or Coxibs, 931’129 metamizole, 1’322’272 weak opioid, and 807’835 strong opioid claims were analyzed. …”
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    Changes over time in prescription practices of pain medications in Switzerland between 2006 and 2013: an analysis of insurance claims
  5. 6245
    “…METHODS: The INSPIRE Population Survey, conducted between March and August 2019, is a cross-sectional survey of older adults aged 75 and older living at home in Canton Basel-Landschaft. The questionnaire was developed by expert input and stakeholder involvement. …”
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    The INSPIRE Population Survey: development, dissemination and respondent characteristics
  6. 6246
    “…In this work, we investigated an outbreak of Hospital associated methicillin-resist Staphylococcus aureus carrying the Panton-Valentine leukocidin gene, which occurred in a large community hospital in Rio de Janeiro, Brazil.…”
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    Hospital-associated methicillin-resistant Staphylococcus aureus carrying the PVL gene outbreak in a Public Hospital in Rio de Janeiro, Brazil
  7. 6247
    “…Rhodococcus erythropolis strain R138 was isolated from the rhizosphere of Solanum tuberosum and selected for its capacity to degrade N-acyl-homoserine lactones, quorum-sensing signals used as communication molecules by the potato pathogens Pectobacterium and Dickeya. …”
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    Genome Sequence of the Quorum-Quenching Rhodococcus erythropolis Strain R138
  8. 6248
    “…The new metabolites 3–6 were biogenically related to resorcylic acid lactones (RALs); however, they did not possess lactonized macrolide elements in their structures. …”
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    New Bioactive β-Resorcylic Acid Derivatives from the Alga-Derived Fungus Penicillium antarcticum KMM 4685
  9. 6249
    “…The discovery of vitamin C as an inhibitor of Rel protein activities raises the prospect of tetrone lactones to prevent such pathways. The closely related isotetrone lactone derivatives are identified herein as inhibitors of the above processes in a mycobacterium. …”
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    C-4-Modified Isotetrones Prevent Biofilm Growth and Persister Cell Resuscitation in Mycobacterium smegmatis
  10. 6250
    por Chatterjee, Ritwika, Jindal, Garima
    Publicado 2023
    “…We have investigated the mechanism and correlation between mutations and exquisite stereoselectivity of a lactone carbene insertion into the C(sp(3))–H bond of substituted aniline, catalyzed by two mutants of a cytochrome P450 variant, “P411” (engineered through directed evolution) in which the axial cysteine has been mutated to serine, utilizing various computational tools. …”
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    Role of mutations in a chemoenzymatic enantiodivergent C(sp(3))–H insertion: exploring the mechanism and origin of stereoselectivity
  11. 6251
    “…[Image: see text] Enzymes capable of hydrolyzing N-acyl-l-homoserine lactones (AHLs) used in some bacterial quorum-sensing pathways are of considerable interest for their ability to block undesirable phenotypes. …”
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    Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 1. Product-Bound Structures
  12. 6252
    “…These loci explain 7.8% of variation in PON1 activity with lactone as a substrate, 5.6% with the arylester, and 3.0% with paraoxon. …”
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    Novel Associations of Nonstructural Loci with Paraoxonase Activity
  13. 6253
    “…In the crystal, O—H⋯O hydrogen bonds involving the hy­droxy, lactone and ester groups and C—H⋯O inter­actions are observed.…”
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    Brusatol
  14. 6254
    “…According to the literatures, this study represents the first report of the norwithasteroids in the side chain with unusual six- and seven-membered ether rings instead of those with an unmodified skeleton (δ-lactone or δ-lactol side chain) and a modified skeleton (γ-lactone or γ-lactol side chain) in the family of withanolides. …”
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    Two Novel Norwithasteroids with Unusual Six- and Seven-Membered Ether Rings in Side Chain from Flos Daturae
  15. 6255
    “…The dihedral angle between the mean planes of the trans-fused seven-membered ring and the lactone ring is 4.42 (9)°.…”
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    13-(N,N-Di­methyl­amino)­micheliolide 0.08-hydrate
  16. 6256
    por Nwokeleme, C. O., Ugwuanyi, J. Obeta
    Publicado 2015
    “…Sample fermented with B. megaterium produced 29 aroma compounds comprising 9 hydrocarbons, 10 esters, 2 nitrogenous compounds, 2 ketones, 3 alcohols, and one of each of lactone, aldehyde, furan, and amine. Methyl esters of various long chain fatty acids may be key aroma compounds, based on consistency and persistence. …”
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    Evolution of Volatile Flavour Compounds during Fermentation of African Oil Bean (Pentaclethra macrophylla Benth) Seeds for “Ugba” Production
  17. 6257
    “…Esterified drimane-type sesquiterpene lactones such as astellolides display various biological activities and are widely produced by plants and fungi. …”
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    Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis
  18. 6258
    “…The enzymatic ring-opening polymerization of lactones is a method of increasing interest for the synthesis of biodegradable and biocompatible polymers. …”
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    CaLB Catalyzed Conversion of ε-Caprolactone in Aqueous Medium. Part 1: Immobilization of CaLB to Microgels
  19. 6259
    “…N-Acylhomoserine lactonase degrades the lactone ring of N-acylhomoserine lactones (AHLs) and has been widely suggested as a promising candidate for use in bacterial disease control. …”
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    AhlX, an N-acylhomoserine Lactonase with Unique Properties
  20. 6260
    “…Six previously undescribed ophiobolin-type sesterterpenes, namely, bipolatoxins A–F (1–6); and one previously undescribed pimarane-type diterpene, namely, 1β-hydroxy momilactone A (7); together with three known compounds, namely, 25-hydroxyophiobolin I (8), ophiobolin I (9), and ophiobolin A lactone (10); were isolated and identified from the endophytic fungus Bipolaris species TJ403-B1. …”
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    Novel Antimicrobial Compounds as Ophiobolin-Type Sesterterpenes and Pimarane-Type Diterpene From Bipolaris Species TJ403-B1
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