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  1. 6301
    “…The main purpose of the present study is to envisage the molecular mechanism of inhibitory action ofdehydrocostuslactone (DCE) andcostunolide (CS), two naturally occurring sesquiterpene lactones, towards the activation of signal transducer and activator of transcription 3 (STAT3). …”
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    Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation
  2. 6302
    “…No antennal response was observed to the Z-isomer or the lactone. In a two-choice olfactometer bioassay, female D. abbreviatus moved upwind towards the synthetic pheromone or natural pheromone more often compared with clean air. …”
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    Identification and Synthesis of a Male-Produced Pheromone for the Neotropical Root Weevil Diaprepes abbreviatus
  3. 6303
    “…Because these results seemed to be contrary to the previous finding, further investigation was performed to find out the underlying cause of the contradiction. As only the lactone form is known to have cytotoxic activity, the proportion of lactone in Val-SN-38 and SN-38 was determined, but no differences were found. …”
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    Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38
  4. 6304
    “…High resolution tandem mass spectrometry was subsequently employed to identify the N-acyl homoserine lactone profile of Aeromonas caviae YL12 and confirmed that this isolate produced two short chain N-acyl homoserine lactones, namely C4-HSL and C6, and the production was observed to be cell density-dependent. …”
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    Quorum Sensing Activity of Aeromonas Caviae Strain YL12, A Bacterium Isolated from Compost
  5. 6305
    “…Although a wide array of plant derived active metabolites play a role in the prevention and treatment of cancer, more extensive scientific evaluation of their mechanisms is still required. Styryl-lactones are a group of secondary metabolites ubiquitous in the genus Goniothalamus that have demonstrated to possess antiproliferative activity against cancer cells. …”
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    Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms
  6. 6306
    “…RESULTS: In the period from March 2003 to December 2014, we have tested 625 children. 351 child were from Sarajevo Canton and 272 children from other cantons. Female children were more affected then male children, in the ratio of 1: 1,105. …”
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    Analysis of Cystic Fibrosis in Federation of Bosnia and Herzegovina
  7. 6307
    “…Accumulation of the signal molecule N-acylhomoserine lactone declined upon treatment with EOs, suggesting direct interaction of EOs with either homoserine lactone synthase (ExpI) or with the regulatory protein (ExpR). …”
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    Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins
  8. 6308
    “…The activity of YVRE using the substrate glucono-δ-lactone was calculated. The results show the function of YVRE as a gluconolactonase, with higher preference to zinc than calcium or magnesium. …”
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    Characterization of a hypothetical protein YVRE from Bacillus subtilis indicates its key role as glucono-lactonase in pentose phosphate pathway and glucose metabolism
  9. 6309
    “…The most likely cluster was detected in 2015, included 20 cantons. The second cluster included 38 cantons, in the years 2014 to 2016. …”
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    Trends and Spatial Patterns of Oral Cancer Mortality in Ecuador, 2001–2016
  10. 6310
    “…The discovery of a novel kraft-derived lactone condensation product proved diagnostic for the identification of a previously unknown homovanillin based condensation pathway. …”
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    Identification of a diagnostic structural motif reveals a new reaction intermediate and condensation pathway in kraft lignin formation
  11. 6311
    por Nazaruk, Jolanta, Kalemba, Danuta
    Publicado 2009
    “…After flash chromatography of essential oil from E. acris, fractions contained acetylene esters and acetylene lactones were obtained. The configuration about double bonds for these compounds has been elucidated on the basis of (1)H- and (13)C-NMR analysis.…”
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    Chemical Composition of the Essential Oils from the Roots of Erigeron acris L. and Erigeron annuus (L.) Pers
  12. 6312
    por Willetts, Andrew
    Publicado 2018
    “…Originally named ‘ketolactonase—an enzyme system for cyclic lactonization’ because of its characterised mode of action, (+)-camphor-induced 2,5-diketocamphane 1,2-monooxygenase was the first example of a Baeyer-Villiger monooxygenase activity to be confirmed in vitro. …”
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    Characterised Flavin-Dependent Two-Component Monooxygenases from the CAM Plasmid of Pseudomonas putida ATCC 17453 (NCIMB 10007): ketolactonases by Another Name
  13. 6313
    “…Guanidine-containing polyhydroxyl macrolides, containing a polyhydroxyl lactone ring and a guanidyl side chain, can be produced by many actinomycetes and have been proved to possess many bioactivities, especially broad-spectrum antibacterial and antifungal activities. …”
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    Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship
  14. 6314
    “…This was an anonymous cross-sectional survey among third-grade schoolchildren and their parents’ oral health habits in Canton Sarajevo. Cluster random sampling yielded a representative sample from all the public schools in Canton Sarajevo in 2019. …”
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    Oral Health Behaviour of Nine-Year-Old Children and Their Parents in Sarajevo
  15. 6315
    “…A total of 180 compounds, including saponins, flavonoids, organic acids, sucrose esters, oligosaccharide esters, phthalides, phenylethanoid glycosides, alkaloids, xanthones, terpene lactones, ionones, and iridoid glycoside, were tentatively characterized. …”
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    Identification of Chemical Components of Qi-Fu-Yin and Its Prototype Components and Metabolites in Rat Plasma and Cerebrospinal Fluid via UPLC-Q-TOF-MS
  16. 6316
    por Li, Yan, Zhang, Zhiqiang
    Publicado 2019
    “…To understand the mechanism and origin of the stereoselectivity of the [3 + 2] annulation reaction between a carboxylic ester and an isatin generating spirooxindole lactone catalyzed by N-heterocyclic carbene (NHC), density functional theory (DFT) calculations have been carried out. …”
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    Mechanism and stereoselectivity in NHC-catalyzed β-functionalization of saturated carboxylic ester
  17. 6317
    “…Eprinomectin (EPR) is currently the only anthelmintic drug of the macrocyclic lactones registered for goats in Europe. The aim of the present study was to gather information regarding the efficacy of anthelmintics against trichostrongyloids on a dairy goat farm in Austria with reported treatment failure of macrocyclic lactones and to determine the presence of different trichostrongyloid genera. …”
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    Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria
  18. 6318
    “…AIMS: The aim of this study is to study the family factors associated with scholastic backwardness in school-going children in Pune Cantonment. MATERIALS AND METHODS: Three hundred school children aged 8–14 years studying in Class III to IX from two government aided semi-Marathi Schools in Pune Cantonment were screened for scholastic backwardness, and evaluation of family-related factors was carried out for positive cases and matched controls. …”
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    A study of family-related factors associated with scholastic backwardness in urban lower middle class school children
  19. 6319
    “…The effect of Bacitracin as an antibiotic acting against Gram-positive bacterial cells was evaluated in combination with hexahistidine-containing organophosphate hydrolase (His(6)-OPH), possessing lactonase activity against various N-acylhomoserine lactones produced by most Gram-negative bacteria as quorum-sensing molecules. …”
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    “Universal” Antimicrobial Combination of Bacitracin and His(6)-OPH with Lactonase Activity, Acting against Various Bacterial and Yeast Cells
  20. 6320
    por Blanco-Cazeaux, Iñaki
    Publicado 2022
    “…There is no trend towards a worsening of this isolation of either the periphery or deprived cantons with regard to the density of GPs in these areas. …”
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    Location dynamics of general practitioners in France
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