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  1. 6621
    “…Compounds 1–4 were the first examples of eudesmane sesquiterpene lactones containing C(5)-OH group. Compound 7 was a highly degraded eudesmane sesquiterpene possessing a rare eleven-carbon skeleton. …”
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  2. 6622
    “…METHODOLOGY AND FINDINGS: Our baseline study involved two data collection methods in the Savelugu-Nanton District (in 2019 the district was separated into Savelugu and Nanton districts) in northern Ghana, comprising a cross-sectional study of 1,000 residents and 24 TMPs between December 2008 and May 2009. …”
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  3. 6623
    “…METHODS: We identified all patients with HCC resident in the canton of Geneva, Switzerland, diagnosed between 1990 and 2014 from the prospective Geneva Cancer Registry and assessed aetiology-specific age-standardised incidence. …”
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  4. 6624
  5. 6625
    “…Our algorithm shows significant speed-up compared to baseline algorithms, being orders of magnitude faster than a random agent and 10 times faster than a lawnmower strategy, even in complex scenarios. The IEB agent is able to make use of received transmitter signals from unknown sources and incorporate both an exploration and search strategy.…”
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  6. 6626
    por Harrison, Thomas, Partridge, David
    Publicado 2022
    “…In this debate, Howard et al. argue in favour of continuing chemoprophylaxis in patients with acute leukaemia receiving systemic chemotherapy, citing the multiple randomized control trials and meta-analyses that demonstrate its efficacy. Taynton et al. argue that fungal biomarker surveillance in the absence of primary antifungal chemoprophylaxis is a safe alternative that could reduce antifungal use and the development of resistance.…”
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  7. 6627
    por CERN. Geneva
    Publicado 2012
    “…--HTML-->CERN, jointly with Canton and City of Geneva, presents the public lecture of Gilles Jobin, the first winner of the Prix Collide@CERN Geneva, residency award for Dance and Performance arts, and his inspiration partner. …”
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  8. 6628
    “…The second route develops from tetralone ring expansion to a B/C-ring intermediate that, by one-step O-demethylation–lactonization–isomerization, affords trigoxyphin K and then trigoxyphin L following enolate oxygenation.…”
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  9. 6629
    “…Rings A, B, C and E have slightly distorted chair conformations, while ring D is most heavily distorted towards a half-chair conformation owing to the strain induced by the lactonization. The ester group attached to ring A is in an equatorial position.…”
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  10. 6630
    “…QS in Pectobacterium carotovorum uses N-acylhomoserine lactone (AHL) based, as well as autoinducer-2 (AI-2) dependent signaling systems. …”
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  11. 6631
    “…The title compound, C(15)H(20)O(5), presents a bis­norsesquiterpene skeleton, with a trans-deca­line backbone constrained by the lactone bridge. The α-hy­droxy substituent and the methyl group belonging to the two deca­line rings are in axial positions, whereas the other methyl group and the acyl group occupy the sterically preferred equatorial positions. …”
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  12. 6632
    “…Key to the success of the approach is the use of a bimetallic [Lewis acid](+)[Co(CO)(4)](−) catalyst for a late-stage regioselective carbonylation of an enantiomerically pure cis-epoxide to a trans-β-lactone. The success of this route to THL and its stereoisomers also demonstrated the practicality of the carbonylation catalyst for complex molecule synthesis as well as its functional group compatibility.…”
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  13. 6633
    “…Under the action of potassium carbonate, α-sulphonyl cycloalkanones are added to functionalized allenyl esters, leading to a lactone intermediate that is subsequently reduced to initiate an intramolecular aldol cyclization to [3.2.1], [3.3.1], and [4.3.1] bicycles. …”
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  14. 6634
    “…In the title compound, C(21)H(20)N(2)O(3), the lactone ring adopts an envelope conformation with the quaternary C atom bonded to two other C atoms as the flap. …”
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  15. 6635
    “…Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). …”
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  16. 6636
    por Hoang, Gia L., Takacs, James M.
    Publicado 2017
    “…The utility of the boronic ester products is further illustrated by other stereospecific C–B bond transformations leading to γ-amino acid derivatives, 1,4-amino alcohols, and 5-substituted-γ-lactone and γ-lactam ring systems.…”
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  17. 6637
    “…To achieve this synthesis, we have explored both the ring-closing metathesis and lactonization-based macrocyclization strategies using a variety of precursors. …”
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  18. 6638
    “…In this regioselective approach, we described a reasonably longer cascade, which proceeds through β-enamino ester formation/Michael addition/intramolecular aldol reaction/elimination/aromatization/oxidative debenzylation/lactonization with a broad substrate scope and high yields. …”
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  19. 6639
    “…Estradiol was selectively glycosylated at C-3 and then transformed to D-ring lactone. Ethynylestradiol was coupled with methylglucoside and 6β-hydroxyderivative was obtained. …”
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  20. 6640
    por Lima, Samia R., Coelho, Fernando
    Publicado 2020
    “…The synthetic usefulness of this protocol was demonstrated by the conversion of selected ketones into biologically valuable α-alkylidene-γ-lactones upon reduction with sodium borohydride. In the course of the scope evaluation, we discovered that this methodology could also furnish α-arylidene-β,γ-butenolides.…”
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