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6781por Divari, Sara, Danelli, Marta, Pregel, Paola, Ghielmetti, Giovanni, Borel, Nicole, Bollo, Enrico“…In brief, 346 rodents were trapped in two rural sites in the Gantrisch Nature Park of Switzerland (Plasselb, canton of Fribourg, and Riggisberg, canton of Bern). …”
Publicado 2021
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6782“…Herein, we reported the first methodology to polymerize six-membered lactone with two substituents vicinal to the ester group (HL), a compound previously found to be non-polymerizable. …”
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6783por Ouchene, Rima, Stien, Didier, Segret, Juliette, Kecha, Mouloud, Rodrigues, Alice M. S., Veckerlé, Carole, Suzuki, Marcelino T.“…Notably, all compounds had fridamycin-like aglycones, and several of them had a lactonized D ring analogous to that of urdamycin L. …”
Publicado 2022
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6784por Benhamou, Simone, Fournier, Evelyne, Puppa, Giacomo, McKee, Thomas, Ris, Frédéric, Rubbia-Brandt, Laura, Viassolo, Valeria, Zilli, Thomas, Zlobec, Inti, Chappuis, Pierre Olivier, Rapiti, Elisabetta“…We established a large population-based cohort of patients with CRC and their first-degree and second-degree relatives registered in the Canton of Geneva, to evaluate the role of family history and tumour biomarkers on patient outcomes. …”
Publicado 2022
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6785por Santa-Ramírez, Hugo-Alejandro, Wisniak, Ania, Pullen, Nick, Zaballa, María-Eugenia, Pennacchio, Francesco, Lorthe, Elsa, Dumont, Roxane, Baysson, Hélène, Guessous, Idris, Stringhini, Silvia“…This study aimed to analyze the association between socio-economic conditions and having developed antibodies for-SARS-CoV-2 in a population-based sample in the canton of Geneva, Switzerland. METHODS: Data was obtained from a population-based serosurvey of adults in Geneva and their household members, between November and December, 2020, toward the end of the second pandemic wave in the canton. …”
Publicado 2022
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6786“…METHODS: A cross-sectional survey was conducted among over-indebted adults seeking advice from one of the four official debt advisory centers in the Canton of Zurich. The survey finally included 219 respondents participating voluntarily and anonymously. …”
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6787por El-Seedi, Hesham R., Yosri, Nermeen, El-Aarag, Bishoy, Mahmoud, Shaymaa H., Zayed, Ahmed, Du, Ming, Saeed, Aamer, Musharraf, Syed G., El-Garawani, Islam M., Habib, Mohamed R., Tahir, Haroon Elrasheid, Hegab, Momtaz M., Zou, Xiaobo, Guo, Zhiming, Efferth, Thomas, Khalifa, Shaden A. M.“…Cardenolides have an unsaturated five-membered lactone ring attached to the steroid nucleus at position 17; bufadienolides have a doubly unsaturated six-membered lactone ring. …”
Publicado 2022
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6788por Cardoza, Rosa E., McCormick, Susan P., Izquierdo-Bueno, Inmaculada, Martínez-Reyes, Natalia, Lindo, Laura, Brown, Daren W., Collado, Isidro G., Proctor, Robert H., Gutiérrez, Santiago“…Gene deletion and biochemical analyses in T. arundinaceum indicated that both genes are required for aspinolide production: asp2 for formation of a 10-member lactone ring and asp1 for formation of a butenoyl subsituent at position 8 of the lactone ring. …”
Publicado 2022
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6789“…The aim of the study was to investigate the knowledge and use of the FIFA 11+ Kids program among soccer coaches of skeletally immature soccer players in a Swiss canton and analyze difficulties of implementing such a prevention program. …”
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6790por Lepage, Mathieu L., Alachouzos, Georgios, Hermens, Johannes G. H., Elders, Niels, van den Berg, Keimpe J., Feringa, Ben L.“…[Image: see text] Butenolides are a class of 5-membered lactones that hold great potential as bio-based monomers to replace oil-derived acrylates, of which they are cyclic analogues. …”
Publicado 2023
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6791Synthesis, characterization and crystal structure of methyl 2-(2-oxo-2H-chromen-4-ylamino)benzoatepor Hollauer, Henrique V. P., Vilas Novas, Rachel C., Guedes, Guilherme P., Buarque, Camilla D., Escobar, Lívia B. L.“…The supramolecular array is formed by hydrogen bonds between the aromatic ring and the O atoms of the lactone and ester portions. The structural details match the spectroscopic data acquired from NMR and IR spectroscopy.…”
Publicado 2023
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6792“…The moss Physcomitrella has been chosen as the candidate organism for production of drug candidates based on terpenoids derived from plants, with a primary focus on the sesquiterpene lactone, thapsigargin. This drug candidate and other candidates/drugs with sesquiterpene skeleton are difficult to obtain by chemical synthesis due to their large number of chiral centers. …”
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6793“…The two aromatic rings are inclined at a dihedral angle of 68.75 (7)° with respect to each other. The lactone ring adopts an envelope conformation. A series of O—H⋯O and C—H⋯O hydrogen bonds contribute to the stabilization of the crystal packing. …”
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6794“…All six-membered rings display chair conformations, with a slight distortion for the lactone ring. The molecules are connected by O—H⋯O hydrogen bonds into chains along [010], with the independent molecules segregated into separate chains. …”
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6795“…A wide range of phytochemical constituents have been isolated from this plant including sesquiterpene lactones, eudesmenolides, flavanoids and essential oil. …”
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6796“…In the title compound (systematic name 1-hydroxy-1,2-dihydroobacunoic acid 3,4-lactone monohydrate), C(26)H(32)O(8)·H(2)O, the dihedral angles between the planes of the ester groups and the furan plane are 43.06 (12) and 56.06 (7)°, while that between the furan plane and the keto group is 58.50 (9)°. …”
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6797“…In the crystal, N—H⋯O—C and N—H⋯O=C hydrogen bonds are formed between the amide group and the two O-atom acceptors of the lactone group, forming a chain along [001].…”
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6798por des Essarts, Yannick Raoul, Sabbah, Mohamad, Comte, Arnaud, Soulère, Laurent, Queneau, Yves, Dessaux, Yves, Hélias, Valérie, Faure, Denis“…In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. …”
Publicado 2013
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6799por Mavlan, Miran, Ng, Kevin, Panesar, Harmanpreet, Yepremyan, Akop, Minehan, Thomas G.“…Key steps in the synthesis involve a Lewis acid mediated Friedel–Crafts type glycosylation and a Yamaguchi lactonization under Yonemitsu conditions. 3,3′-Di-O-methyl ardimerin aggregates in aqueous solutions at concentrations greater than 1 μM, and both UV and fluorescence binding studies indicate that 15 has a low affinity for duplex DNA.…”
Publicado 2014
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6800“…In each molecule, the lactone ring has an envelope conformation with the spiro C atom as the flap. …”
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