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6801por Čikoš, Ana, Ćaleta, Irena, Žiher, Dinko, Vine, Mark B, Elenkov, Ivaylo J, Dukši, Marko, Gembarovski, Dubravka, Ilijaš, Marina, Dragojević, Snježana, Malnar, Ivica, Alihodžić, Sulejman“…We present the formation of a [4.5]spiroketal moiety within the macrolide lactone ring, but also the unexpected formation of a 10-C=11-C double bond and spontaneous change of stereochemistry at position 8-C. …”
Publicado 2015
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6802por Suhaili, Zarizal, Lean, Soo-Sum, Mohamad, Noor Muzamil, Rachman, Abdul R. Abdul, Desa, Mohd Nasir Mohd, Yeo, Chew Chieng“…Therefore, here we report the draft genome sequence of the methicillin-susceptible Staphylococcus aureus (MSSA) with sequence type 1 (ST1), spa type t127 with Panton-Valentine Leukocidin (pvl) pathogenic determinant isolated from pus sample designated as KT/314250 strain. …”
Publicado 2016
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6803por Devescovi, Giulia, Kojic, Milan, Covaceuszach, Sonia, Cámara, Miguel, Williams, Paul, Bertani, Iris, Subramoni, Sujatha, Venturi, Vittorio“…In Chromobacteium violaceum, the purple pigment violacein is under positive regulation by the N-acylhomoserine lactone CviI/R quorum sensing system and negative regulation by an uncharacterized putative repressor. …”
Publicado 2017
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6804“…The synthesis of β-lactones from epoxides through ring-expanding carbonylation using homogeneous catalysts has received much attention. …”
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6805por Huang, Sheng Zhuo, Ma, Qing Yun, Wang, Qi, Dai, Hao Fu, Liu, Yu Qing, Zhou, Jun, Zhao, You Xing“…Daphnauranin C is a 9-O-13 etherified and hydroperoxy-substituted guaiane sesquiterpenoid, daphnauranin D is a guaiane sesquiterpenoid ketal, and daphnauranin E is a monoterpenoid lactone. Their structures were elucidated by comprehensive analyses of MS, 1D NMR, and 2D NMR spectroscopic data. …”
Publicado 2018
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6806“…Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. …”
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6807por Sinanovic, Osman, Avdibegovic, Esmina, Hasanovic, Mevludin, Pajevic, Izet, Sutovic, Alija, Loga, Slobodan, Ceric, Ismet“…The FBH, with 2 325 018 residents, is a federation of 10 cantons, which have equal rights and responsibilities. …”
Publicado 2009
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6808por Noor, Ahmad Omar, Almasri, Diena Mohammedallam, Bagalagel, Alaa Abdullah, Abdallah, Hossam Mohamed, Mohamed, Shaimaa Gamal Abdallah, Mohamed, Gamal Abdallah, Ibrahim, Sabrin Ragab Mohamed“…Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. …”
Publicado 2020
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6809“…Four new bonds, three functional groups (lactone, ketal, and alcohol) and four contiguous stereocenters are formed during this regio‐ and diastereoselective process in a single synthetic step. …”
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6810“…Compounds 1−3 possessed an unusual C-23 spirostructure moiety, while compounds 4−7 had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds 3 and 5 exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2).…”
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6811por Yiannakas, Ektoras, Grimes, Mark I., Whitelegge, James T., Fürstner, Alois, Hulme, Alison N.“…The convergent synthetic strategy orchestrates bisalkyne fragment‐assembly using an unprecedented Schöllkopf‐type condensation on a substituted β‐lactone and an ambitious late‐stage one‐pot alkyne cross metathesis–ring‐closing metathesis (ACM–RCAM) reaction. …”
Publicado 2021
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6812“…Derivatization of the succinimides was straightforward and provided access to chiral pyrrolidines, lactones, and lactams. Kinetic studies, including a Hammett plot, provided detailed insight into the reaction mechanism.…”
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6813por Liu, Lanying, Guan, Fuqin, Chen, Yu, Wang, Fan, Chen, Pengxu, Yin, Min, Wang, Bi, Li, Linwei, Wang, Qizhi, Gu, Yonghua, Feng, Xu“…Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-β-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3–7). …”
Publicado 2022
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6814por Viera, Carlos R., Stevens, Bradley T., Viera, Talysa, Zielinski, Cameron, Uranga, Lee A., Rogelj, Snezna, Patidar, Praveen L., Tello-Aburto, Rodolfo“…A series of cystargolide-based β-lactone analogues containing nitrogen atoms at the Pz portion of the scaffold were prepared and evaluated as proteasome inhibitors, and for their cytotoxicity profile toward several cancer cell lines. …”
Publicado 2022
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6815por Versaevel, Marie, Braquenier, Jean-Baptiste, Riaz, Maryam, Grevesse, Thomas, Lantoine, Joséphine, Gabriele, SylvainEnlace del recurso
Publicado 2014
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6816“…Recent trends in lip cancer incidence in the Swiss Canton of Vaud (approximately 600,000 inhabitants in 1990) were analysed over the period 1975-1990, when a total of 87 cases were registered. …”
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6817“…Between 1976 and 1996, 176 borderline ovarian tumours were registered in the Cancer Registry of the Swiss canton of Vaud, corresponding to an age-adjusted incidence (world standard) of 2.7 in 100 000. …”
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6818por Emanuel, Linda“…This is a commentary on “Attitudes of legal guardians of ventilated ICU patients toward the process of decision making associated with invasive nonlife-saving procedures” by Michael Kuniavsky, Freda DeKeyser Ganz, David M Linton, and Sigal Sviri. Kuniavsky and colleagues report that decision-making for the seriously ill is difficult for the patients’ legal guardians, many of whom would be comfortable with doctors making the decisions. …”
Publicado 2012
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6819por Gelencsér, Zsolt, Galbáts, Borisz, Gonzalez, Juan F., Choudhary, K. Sonal, Hudaiberdiev, Sanjarbek, Venturi, Vittorio, Pongor, Sándor“…Pseudomonas spp. are able to colonize a large variety of environments due to their wide adaptability which is also associated with an N-acyl homoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). …”
Publicado 2012
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6820“…Starting from the conveniently available ex-chiral pool building block (R,R)-hexa-1,5-diene-3,4-diol, the ten-membered ring lactones stagonolide E and curvulide A were synthesized using a bidirectional olefin-metathesis functionalization of the terminal double bonds. …”
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