“…Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol to a juxtanuclear location. …”
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“…Among them, compound 2 represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member γ-lactone ring. Moreover, the new compounds (1–5) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.…”
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“…Negative interactions have been seen for homoserine-lactones, pyoverdine and pyochelin resulting from iron starvation and intracellular inhibitory reactive oxidant production. …”
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“…A variety of initiators broaden the areas of organocatalysis in polymerization of different monomers, such as lactones, cyclic carbonates, lactides or gycolides, ethylene phosphates and phosphonates, and others. …”
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“…The survey data was matched with cantonal farm census data, containing information on farm size, farm type and age of the farmers.…”
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“…Virus was purified by ultracentrifugation on 30% glycerol cushion followed by differential centrifugation on 10–60% sucrose gradient and inactivated with β-propio lactone at a concentration of 1:3500. The inactivated product was blended with aluminium phosphate (3%) and immunized 4-week-old Swiss albino mice. …”
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“…However, prevailing thinking places acyl homoserine lactones (AHLs) at the forefront of this communication pathway in Gram‐negative bacteria. …”
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“…She is now a postdoctoral researcher in the lab of Erika Bach at NYU Langone Health, New York, NY, USA, investigating host pathophysiology upon Zika virus infection using Drosophila developing organs as the model system.…”
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“…Andrographolide, a diterpene lactone from Andrographis paniculata was brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. …”
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“…Dehydroleucodine is a bioactive sesquiterpene lactone. Herein, four dehydroleucodine amino derivatives were synthesized using the amines proline, piperidine, morpholine, and tyramine, and spectroscopic methods and single-crystal X-ray diffraction unambiguously established their structures. …”
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“…In this paper, we report an innovative synthetic method for their preparation from Glc-, Man-, and GlcNAc- lactone derivatives. The proposed original strategy involves the addition of the corresponding δ-hexonolactones onto the dianion of (methylphosphino) phosphonate as a key step, followed by dehydration and stereoselective addition of dihydrogen on the resulting double bond. …”
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“…Laser trilobum, which contains a structurally related sesquiterpene lactone, trilobolide (Tb), is successfully cultivated. …”
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“…A sesquiterpene lactone, thapsigargin, is a phytochemical found in the roots and fruits of Mediterranean plants from Thapsia L. species that have been used for centuries in folk medicine to treat rheumatic pain, lung diseases, and female infertility. …”
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“…Pronounced shifts—which persisted post-lockdown—can be observed from urban to suburban and rural areas and among cantons. Data allow us to identify directly two sources of shifts: “tourists and business travelers” and “e-commerce.” …”
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“…Within the animal health market many different heartworm preventive products are available, all of which contain active components of the same drug class, the macrocyclic lactones. In addition to compliance issues, such as under-dosing or irregular treatment intervals, the occurrence of drug-resistant heartworms within the populations in the Mississippi River areas adds to the failure of preventive treatments. …”
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“…Density functional theory calculations indicate that the formation of macrocycles is more favorable than that of 9-membered-ring lactones in terms of kinetics and thermodynamics. The potential utility of these intriguing chiral macrodiolide molecules is demonstrated in the enantiomeric recognition of aminols and chemical recognition of metal ions.…”
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“…A total of 8317 young people in ten cantons were interviewed about right-wing, left-wing and Islamist extremism. …”
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“…Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The α-C(sp(3))-H arylation of these compounds have been exhibited high efficiency in forming C(sp(3))-C(sp(2)) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. …”
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“…Herein, we report a three-step synthetic method for the preparation of saccharide-silicone surfactants using the natural linker, cysteamine, and saccharide lactones. The Piers–Rubinsztajn plus thiol-ene plus amidation process is attractive for several reasons: if employed in the correct synthetic order, it allows for precise tailoring of both hydrophobe and hydrophile; it permits the ready utilization of natural hydrophiles cysteamine and saccharides in combination with silicones, which have significantly better environmental profiles than PEG; and the products exhibit interesting surface activities.…”
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“…In an exemplification of this technology, electrochemical sensors were developed for the determination of concentrations of trypsin, glucose, paracetamol, C4-homoserine lactone, and THC. The present technology allows for the possibility of producing generic, inexpensive, and robust disposable sensors for clinical, environmental, and forensic applications.…”
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