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7121“…The Director-General of CERN inserts the time capsule containing a document submitted by the Republic and Canton of Geneva. This historic document from 1952 is the telegram by which the President of the Council of State at the time, Mr. …”
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7122“…Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine. …”
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7123“…Finally, the PFA prepared in neat conditions showed terminal lactones instead of aldehydes.…”
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7124“…LuxR solos have been implicated in intraspecies, interspecies, and interkingdom communication by sensing endogenous and exogenous acyl-homoserine lactones (AHLs) as well as non-AHL signals. LuxR solos are likely to play a major role in microbiome formation, shaping, and maintenance through many different cell-cell signaling mechanisms. …”
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7125“…The scaffold hopping via lactone ring opening enabled the new derivatives of vulgarin (1 and 2) to fit well inside the COX-2 active site with ΔG of −7.73 and −7.58 kcal/mol, respectively, which was better than that of naproxen (ΔG of −7.04 kcal/mol). …”
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7126“…Clavirolides J–K are characterized by a 1,11- and 5,9-fused tricyclic tetradecane scaffold fused with a α,β-unsaturated-δ-lactone, and clavirolide L possesses a 1,11- and 3,5-fused tricyclic tetradecane scaffold, which extend the dolabellane-type scaffolds. …”
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7127por Wang, Yihong, Young, Claire M., Cordes, David B., Slawin, Alexandra M. Z., Smith, Andrew D.“…In all cases, preferential [2 + 2]-cycloaddition over the alternative [4 + 2]-cycloaddition is observed, giving β-lactones with excellent diastereo- and enantioselectivity (34 examples, up to >95:5 dr, >99:1 er). …”
Publicado 2023
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7128por Sánchez-Morgado, José M“…In this observational retrospective study, an outbreak of Staphylococcus aureus abscesses was correlated with the presence of sharp edges in damaged plastic environmental enrichment within the cages. In 2010, Lawson reported cases of S. aureus mandibulofacial and maxillofacial abscess in mice and proposed excessive barbering or grooming, leading to the mastication and fragmentation of hair, as an aetiopathogenesis of S. aureus abscesses. …”
Publicado 2023
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7129“…Specific reactions described here are umpolung C–C bond forming reactions between aromatic ketones or imines and electron-poor alkenes, imino-pinacol homocoupling reactions of challenging alkyl-aryl imine substrates, and γ-lactonization reactions of aromatic ketones with methyl acrylate. …”
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7130por Grzesiński, Łukasz, Milewski, Mariusz, Nadirova, Maryana, Kajetanowicz, Anna, Grela, Karol“…Interestingly, despite being not productive in metathesis reactions conducted in solution, Ru8 enabled the synthesis of a model 16-membered macrocyclic lactone of valuable musk smell with excellent chemoselectivity (no C–C double-bond migration was observed) at a concentration 40 times higher than that typically used by organic chemists in similar macrocyclizations (200 mM instead of 5 mM) with excellent Z-selectivity. …”
Publicado 2022
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7131“…However, group VI Ca2+-independent PLA2 (iPLA2) seems to contribute to the arachidonic acid liberation too, since the relatively specific iPLA2 inhibitor bromoenol lactone (BEL) decreased arachidonic acid generation in part. …”
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7132“…Four sublines CMT167, 170, 175 and 181 with increased metastatic ability were selected, as described in the accompanying paper (Layton & Franks, 1984). The tissue culture cells and the tumours produced by all the lines are well differentiated and produce laminated surfactant-like bodies as well as basal lamina, even in metastases. …”
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7133por Tinelli, Marco, Monaco, Monica, Vimercati, Maurizio, Ceraminiello, Antonio, Pantosti, Annalisa“…Molecular typing of the isolates showed an epidemic methicillin-susceptible S. aureus (MSSA) strain, spa type 005 and sequence type 22 that harbored Panton-Valentine leukocidin (PVL) genes. The first case-patients were neonates or mothers who had recently delivered in the local hospital. …”
Publicado 2009
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7134por Bukharie, Huda A.“…CA-MRSA infections have mostly been associated with staphylococcal strains bearing the staphylococcal cassette chromosome mec type IV element and Panton-Valentine leukocidin genes. These strains are more frequently susceptible to a variety of non-beta-lactam antibiotics. …”
Publicado 2010
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7135por Moumou, Mohamed, Benharref, Ahmed, Oudahmane, Abdelghani, Elhakmaoui, Ahmed, Berraho, Moha“…The dihedral angle between the mean planes of the ten-membered ring and the lactone ring is 20.8 (3)°. An intramolecular O—H⋯N hydrogen-bond occurs. …”
Publicado 2011
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7136por Moumou, Mohamed, Benharref, Ahmed, Daran, Jean-Claude, Elhakmaoui, Ahmed, Akssira, Mohamed, Berraho, Moha“…The molecule is built up from fused five- and ten-membered rings. The five-membered lactone ring has an envelope conformation with the flap atom, C(H)-C-C(H), displaced by 0.2325 (15) Å from the mean plane through the remaining four atoms, whereas the ten-membered ring displays an approximate chair–chair conformation. …”
Publicado 2011
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7137por Stanchev, Stancho, Jensen, Frank, Hinkov, Anton, Atanasov, Vasil, Genova-Kalou, Petia, Argirova, Radka, Manolov, Ilia“…The most significant functional groups, responsible for the interaction with HIV-1 protease by hydrogen bonds formation are pyran oxygen, atom, lactone carbonyl oxygen and one of the hydroxyl groups. …”
Publicado 2011
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7138por Yilmaz, Necat“…Although the preferred endogenous substrate of PON1 remains unknown, lactones comprise one possible candidate class. Homocysteine-thiolactone can be disposed of by enzymatic hydrolysis by the serum Hcy-thiolactonase/paraoxonase carried on high-density lipoprotein (HDL). …”
Publicado 2012
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7139“…As the most effective drug against malaria, artemisinin, a sesquiterpene lactone is derived from GSTs of Artemisia annua. However, low artemisinin content (0.001%∼1.54% of dry weight) has hindered its wide application. …”
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7140“…In the title HBr salt of (S)-homoserine lactone, C(4)H(8)NO(2) (+)·Br(−), the five-membered ring has an envelope conformation, with the –CH(2)– C atom adjacent to the N-substituted C atom at the flap position. …”
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