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7381Hyperisampsins H–M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsoniipor Zhu, Hucheng, Chen, Chunmei, Tong, Qingyi, Chen, Xintao, Yang, Jing, Liu, Junjun, Sun, Bin, Wang, Jianping, Yao, Guangmin, Luo, Zengwei, Xue, Yongbo, Zhang, Yonghui“…Compounds 1 and 2 represent the first examples of PPAPs possessing a unique γ-lactone ring at C-23, while 3–6 differed from normal PPAPs with an unprecedented 1,2-dioxane ring. …”
Publicado 2015
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7382por Qin, Si-Yong, Peng, Meng-Yun, Rong, Lei, Li, Bin, Wang, Shi-Bo, Cheng, Si-Xue, Zhuo, Ren-Xi, Zhang, Xian-Zheng“…Camptothecin (CPT)-based drugs always undergo the reversible, pH-dependent lactone ring-opening reaction, yielding the inactive but toxic carboxylate form. …”
Publicado 2015
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7383por Marchetti, Gabriela M, Silva, Karina A, Santos, Arianny N, Sousa, Ilza MO, Tinti, Sirlene V, Figueira, Glyn M, Foglio, Mary A, Carvalho, João E“…Most of the pharmacological activities are credited to germacranolides, a sesquiterpene lactone common to this genus. Dried aerial parts of Calea pinnatifida Banks were extracted with dichloromethane, which generated the dichloromethane crude extract (DCE). …”
Publicado 2012
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7384“…Its contents included flavonoids, alkaloids, phenols and sesquiterpene lactones. CONCLUSION: Corneal exposure to E. grandicornis sap is a cause of nonvisually threatening keratouveitis when adequately treated with corticosteroids.…”
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7385“…Quantitation of (1)H-(13)C HSQC (Heteronuclear Single Quantum Coherence) signals revealed that the concentrations of glucose, glucono-1,5-lactone, glycerol phosphate, glutamine, glycine, leucine, isoleucine, lysine, ornithine, proline, threonine and valine were higher in the herbivore larvae.…”
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7386por Gao, Ling, Liu, Hongxia, Ma, Zhi, Han, Jinzhi, Lu, Zhaoxin, Dai, Chen, Lv, Fengxia, Bie, Xiaomei“…The TE was capable of recognizing and catalysing the lactone formation between (L)-Try(3) with the last few residues (L)-Pro7 and (L)-Gln8 at the C-terminus. …”
Publicado 2016
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7387por Abduzaimovic, Amila, Aljicevic, Mufida, Rebic, Velma, Vranic, Sabina Mahmutovic, Abduzaimovic, Kadrija, Sestic, Sabina“…In cooperation with the Microbiological laboratory of the Cantonal Hospital Zenica and the Microbiological laboratory of the General Hospital Tesanj, 3863 urine samples were processed in the period from March 1(st) to March 31(st) 2016. …”
Publicado 2016
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7388“…The title compound, erioflorin, C(19)H(24)O(6) [systematic name: (1aR,3S,4Z,5aR,8aR,9R,10aR)-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-3-hydroxy-4,10a-dimethyl-8-methylidene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl methacrylate], is a tricyclic germacrane sesquiterpene lactone, which was isolated from Podanthus mitiqui (L.). …”
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7389por Carroll, David E., Marr, Ian, Huang, G Khai Lin, Holt, Deborah C., Tong, Steven Y. C., Boutlis, Craig S.“…The isolate was non–multidrug-resistant, methicillin-resistant Staphylococcus aureus and was genotyped as clonal complex 5, an emerging regional clone that is trimethoprim resistant and Panton-Valentine leukocidin positive. This current case report is the first to describe the use of clindamycin step-down therapy. …”
Publicado 2017
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7390por Mazur, Marcelina, Gładkowski, Witold, Srček, Višnja Gaurina, Radošević, Kristina, Maciejewska, Gabriela, Wawrzeńczyk, Czesław“…Regardless of the biocatalyst applied, the δ-iodo- and δ-bromo-γ-lactones were hydroxylated in an inactivated position C-5 of cyclohexane ring. …”
Publicado 2017
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7391por Song, Xiaoguang, Lu, Zefu, Yu, Hong, Shao, Gaoneng, Xiong, Jinsong, Meng, Xiangbing, Jing, Yanhui, Liu, Guifu, Xiong, Guosheng, Duan, Jingbo, Yao, Xue-Feng, Liu, Chun-Ming, Li, Hongqing, Wang, Yonghong, Li, Jiayang“…Strigolactones (SLs), a group of carotenoid derived terpenoid lactones, are root-to-shoot phytohormones suppressing shoot branching by inhibiting the outgrowth of axillary buds. …”
Publicado 2017
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7392“…Chemically, bufadienolides are a group of polyhydroxy C-24 steroids and their glycosides, containing a six-membered lactone (α-pyrone) ring at the C-17β position. From the pharmacological point of view, bufadienolides might be a promising group of steroid hormones with cardioactive properties and anticancer activity. …”
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7393“…Particularly great burden is on the population of the Zenica-Doboj Canton (ZDC), which can be due to the traditional relation to the preparation and storage of food, as well as to the relatively poorer economic situation in ZDC. …”
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7394por Moschetti, Karine, Zabrodina, Véra, Wangmo, Tenzin, Holly, Alberto, Wasserfallen, Jean-Blaise, Elger, Bernice S., Gravier, Bruno“…This study assesses the determinants of individual health care expenditures within the prisons of the canton of Vaud, a large region of Switzerland. METHODS: We use a unique dataset linking demographic and prison stay characteristics as well as objective measures of morbidity to detailed medical invoice data. …”
Publicado 2018
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7395por O’Callaghan, Richard J.“…A variety of bacterial secreted proteins including alpha-toxin, beta-toxin, gamma-toxin, Panton-Valentine leukocidin and other two-component leukocidins mediate tissue damage and contribute to the induction of the inflammatory response. …”
Publicado 2018
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7396por Carlsson, Gunilla H, Hasse, Dirk, Cardinale, Francesca, Prandi, Cristina, Andersson, Inger“…Strigolactones, a group of terpenoid lactones, control many aspects of plant growth and development, but the active forms of these plant hormones and their mode of action at the molecular level are still unknown. …”
Publicado 2018
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7397“…Glucose oxidase (GO) catalyzes the conversion ofβ‐D‐glucose and molecular oxygen to Dδ‐glucono‐δ‐lactone and H(2)O(2). H(2)O(2) produced by GO was effective in preventing tumor growth in mice bearing not only ascites tumor but also solid tumor. …”
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7398“…However, processes involved in the disturbance of QS also occur in this bacteria under the molecular form of a protein, TraM, inhibiting the sensing of the QS signals, and two lactonases BlcC (AttM) and AiiB that degrade the acylhomoserine lactone (AHL) QS signal. In the model Agrobacterium fabrum strain C58, several data, once integrated, strongly suggest that the QS regulation may not be reacting only to cell concentration. …”
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7399por Pessôa, Marco T. C., Alves, Silmara L. G., Taranto, Alex G., Villar, José A. F. P., Blanco, Gustavo, Barbosa, Leandro A.“…We have synthesised a series of digoxin derivatives (γ-Benzylidene digoxin derivatives) with substitutions in the lactone ring (including non-oxygen and ether groups), to obtain CTS with better NKA isoform specificity. …”
Publicado 2017
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7400“…Characterizing MRSA strains can be done by antimicrobial susceptibility testing, detection of Panton–Valentine leukocidin (PVL) gene, staphylococcal cassette chromosome mec (SCCmec) typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). …”
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