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  1. 7541
    por Tian, Shuang, Yu, Hongdan
    Publicado 2017
    “…Atractylenolide II (AT-II) exhibits several biological and pharmacological functions, especially anti-cancer activity as the major sesquiterpene lactones isolated from Atractylodes macrocephala (also named Baizhu in Chinese). …”
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    Atractylenolide II Inhibits Proliferation, Motility and Induces Apoptosis in Human Gastric Carcinoma Cell Lines HGC-27 and AGS
  2. 7542
    “…A total of 64, 39, 56, 52, and 44 components were identified in the essential oils of Jinshuibao capsule (JSBC), Bailing capsule (BLC), Zhiling capsule (ZLC), Ningxinbao capsule (NXBC), and Xinganbao capsule (XGBC), respectively. 5,6-Dihydro-6-pentyl-2H-pyran-2-one (massoia lactone) was first discovered as the dominant component in JSBC volatiles. …”
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    GC-MS Profiling of Volatile Components in Different Fermentation Products of Cordyceps Sinensis Mycelia
  3. 7543
    “…Recently, a new chemical entity (NCE) named Pyranaphthoquinone (IVS320) was synthesized from lawsone. We report herein, a detailed study of the physicochemical properties and in vitro trypanocidal activity of IVS320. …”
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    Characterization and Trypanocidal Activity of a Novel Pyranaphthoquinone
  4. 7544
    “…Here, we explored DNA damage responses in MCF-7 cells treated with our novel synthetic hybrid compound AD-013, which integrates a coumarin moiety and an α-methylene-δ-lactone motif. The mRNA expression of several genes engaged in DNA-damage-induced responses was assessed by quantitative real-time PCR. …”
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    Involvement of a coumarin analog AD-013 in the DNA damage response pathways in MCF-7 cells
  5. 7545
    “…A new C(9) monoterpenoid acid (litseacubebic acid, 1) and a known monoterpene lactone (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide (2), along with three known compounds – vanillic acid (3), trans-3,4,5-trimethoxylcinnamyl alcohol (4), and oxonantenine (5) – were isolated with bioassay-guided purification from the fruit extract of Litsea cubeba collected in Tibet. …”
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    The Fungicidal Terpenoids and Essential Oil from Litsea cubeba in Tibet
  6. 7546
    “…Acidic SLs with high water solubility were more effective than lactonic SLs in enhancing remediation of heavy metal-contaminated soils. …”
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    Removal of Cadmium and Lead from Contaminated Soils Using Sophorolipids from Fermentation Culture of Starmerella bombicola CGMCC 1576 Fermentation
  7. 7547
    “…Three known triterpenoids, namely ursolic acid (1), and the 27-E- and 27-Z-p-coumaric esters of ursolic acid (compounds 2, 3), were isolated together with a new triterpene 2,3-seco-taraxer-14-en-2,3-lactone [pycanocarpine (4)] from an ethanolic extract of Pleiocarpa pycnantha leaves. …”
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    An Unusual 2,3-Secotaraxerene and Other Cytotoxic Triterpenoids from Pleiocarpa pycnantha (Apocynaceae) Leaves Collected from Nigeria
  8. 7548
    “…Costunolide (CS) is a well-known sesquiterpene lactone, used as a popular herbal remedy, which possesses anti-inflammatory and antioxidant activity. …”
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    Protective Effects of Costunolide against Hydrogen Peroxide-Induced Injury in PC12 Cells
  9. 7549
    “…METHODS: This observational study was conducted at the Layton Rahmatullah Benevolent Trust (LRBT), Free Base Eye Hospital, Karachi, from April 2018 to June 2018. …”
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    Clinical application of multicolor optical coherence tomography in the diagnosis of retinal pathologies
  10. 7550
    “…Quorum sensing (QS) promotes in situ extracellular enzyme (EE) activity via the exogenous signal N-acylhomoserine lactone (AHL), which facilitates marine particle degradation, but the species that engage in this regulatory mechanism remain unclear. …”
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    Quorum Sensing System of Ruegeria mobilis Rm01 Controls Lipase and Biofilm Formation
  11. 7551
    “…QS inhibitory activity was demonstrated by the reduction in swinging motility (61.49%), swarming motility (74.94%), biofilm formation (52.41%) and acyl-homoserine lactone (AHL) production (0.5 μL/mL). Additionally, in silico analysis and RT-qPCR studies for AHL synthase HalI and QS transcriptional regulator HalR revealed a plausible molecular mechanism for QS inhibition by L-carvone. …”
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    Reducing Quorum Sensing-Mediated Virulence Factor Expression and Biofilm Formation in Hafnia alvei by Using the Potential Quorum Sensing Inhibitor L-Carvone
  12. 7552
    “…Alantolactone (ATL), a sesquiterpene lactone, has been shown to have potential anti‐tumour activity against various cancer cells. …”
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    Alantolactone promotes ER stress‐mediated apoptosis by inhibition of TrxR1 in triple‐negative breast cancer cell lines and in a mouse model
  13. 7553
    “…In particular, sesquiterpene lactones (SLs) may cause sensitization resulting in skin irritation and inflammation. …”
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    Asteraceae species as potential environmental factors of allergy
  14. 7554
    “…In that process, spontaneous dialdehyde/lactone isomerization was observed for some of the isolated secondary metabolites, and novel stachybotrychromenes were quantitatively investigated for the first time. …”
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    Exploring Secondary Metabolite Profiles of Stachybotrys spp. by LC-MS/MS
  15. 7555
    “…They are classified into categories based on their functional groups and biosynthesis pathways: (1) higher alcohols and esters, (2) polyfunctional thiols, (3) lactones and furanones, and (4) terpenoids. Yeast and hops are the main sources of fruity and flowery aroma compounds in beer. …”
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    The molecular biology of fruity and floral aromas in beer and other alcoholic beverages
  16. 7556
    “…The polymerization catalysis exploits mechanistic switches between anhydride/epoxide ring-opening copolymerization, epoxide ring-opening polymerization and lactone ring-opening polymerization without requiring any external stimuli. …”
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    Easy access to oxygenated block polymers via switchable catalysis
  17. 7557
    “…The importance of other toxins, such as β-toxin, γ-toxin, and Panton–Valentine leukocidin (PVL), have been analyzed to a lesser degree and their roles in eye infections are less clear. …”
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    An Eye on Staphylococcus aureus Toxins: Roles in Ocular Damage and Inflammation
  18. 7558
    “…To achieve fine tuning of the optical and electrochemical properties, the electron-poor thiophene-bis-lactone moiety has been decorated with donor (D) and acceptor groups (A), targeting fully conjugated D–A−π–A structures. …”
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    New Blue Donor–Acceptor Pechmann Dyes: Synthesis, Spectroscopic, Electrochemical, and Computational Studies
  19. 7559
    “…The activated methyl cycle (AMC) is responsible for the generation of S-adenosylmethionine (SAM), which is a substrate of N-acylhomoserine lactone (AHL) synthases. However, it is unknown whether AHL-mediated quorum sensing (QS) plays a role in the metabolic flux of the AMC to ensure cell density-dependent biosynthesis of AHL in cooperative populations. …”
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    Unraveling the role of quorum sensing-dependent metabolic homeostasis of the activated methyl cycle in a cooperative population of Burkholderia glumae
  20. 7560
    “…We speculate that cytotoxic and antibiotic effects observed in the tested resistant models may be due to the coordinate activities of forty compounds detected or to the C(16) macrocyclic lactones which are the major ones (30%). Our data confirm the possibility of using EOs as therapeutic strategies in resistant models is due to the heterogeneous composition of the oils themselves.…”
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    Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models
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