“…When exposed to a variety of quorum sensing molecules from different bacterial species and from Candida albicans we found that N-(3-oxododecanoyl)-L-homoserine lactone (C12) from the opportunistic human pathogen Pseudomonas aeruginosa induces a remarkable stress response in yeast. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHOD: Participants (n = 212) rated sets of stimuli repeated three times at weekly intervals: images of Picasso’s paintings, PANTONE color cards, and avant-garde music clips. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Other metabolites of the roots were abietane diterpenoids, common in Salvia species, and pentacyclic triterpenoids, bearing a γ-lactone moiety, previously undescribed in Salvia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Incomptine A (IA) is a sesquiterpene lactone isolated from Decachaeta incompta that induces apoptosis, reactive oxygen species production, and a differential protein expression on the U-937 (diffuse histiocytic lymphoma) cell line. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The genomic features of VL1 were similar to those of the non-pathogenic M. indicum strain SE2.11(T); however, VL1 possessed additional unique genes, including those related to homoserine lactone biosynthesis. We established a loop-mediated isothermal amplification (LAMP) assay using the unique sequences of VL1 as target sequences for the rapid and simple detection of pathogenic M. indicum strains. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A comparison of the activities of compounds 1–8 revealed that the presence of a trans-lactone (linkage of C-6 to C-7) correlated with increased activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our study furthermore pointed at endogenous effects associated with consumption of dairy products containing glucono-δ-lactone.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this paper, we harness the unique large MOBIS:COVID-19 GPS travel diary data on mobility behaviour collected during a normal baseline period and during the first wave of the Covid-19 pandemic in the Canton of Zurich Switzerland. We estimate a sufficiency rate that allows to geolocate locations where the demand for public open space is higher than the available offer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Computer modeling revealed the preferences between certain polyelectrolyte partners for N-acyl-homoserine lactone acylase and hexahistidine-tagged organophosphorus hydrolase (His(6)-OPH) possessing the quorum quenching (QQ) behavior with bacterial cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At a national level, the hybrid model improved, prediction accuracy (i.e., mean absolute error) by 74%. At the cantonal and hospital levels, the reduction on the forecast’s mean absolute error were 46% and 50%, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Coronarin D (2) markedly promoted the differentiation of NSCs into astrocytes up to approximately 4 times (3.64 ± 0.48) and increased the expression level of GFAP at the mRNA and protein level, while compounds 1 and 3 exhibited only weak effects, suggesting that the 15-hydroxy-Δ(12)-γ-lactone moiety is important for bioactivity. Moreover, compound 2 increased the number of pSTAT3-positive cells, suggesting that compound 2 promoted astrocytic differentiation through JAK/STAT signaling pathway.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A polyoxygenated and halogenated labdane, spongianol (1); a polyoxygenated steroid, 3β,5α,9α-trihydroxy-24S-ethylcholest-7-en-6-one (2); a rare seven-membered lactone B ring, (22E,24S)-ergosta-7,22-dien-3β,5α-diol-6,5-olide (3); and an α,β-unsaturated fatty acid, (Z)-3-methyl-9-oxodec-2-enoic acid (4) as well as five known compounds, 10-hydroxykahukuene B (5), pacifenol (6), dysidamide (7), 7,7,7-trichloro-3-hydroxy-2,2,6-trimethyl-4-(4,4,4-trichloro-3-methyl-1-oxobu-tylamino)-heptanoic acid methyl ester (8), and the primary metabolite 2’-deoxynucleoside thymidine (9), have been isolated from the Red Sea sponge Spongia sp. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Bufadienolides are one type of cardiac aglycone with a six-member lactone ring and have properties of antitumor, cardiotonic, tonsillitis, and anti-inflammatory. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At pH 12.5, hydrolyzation of the lactone ring starts in less than one hour, but only after two hours does the degradation process lead to fragmentation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The bacterial virulence is regulated via quorum-sensing, a cell–cell communication process precisely controlled by autoinducer molecules such as acyl homoserine lactone (AHL). The present study aimed at identifying promising quorum-sensing inhibitors in Pseudomonas aeruginosa, an opportunistic human pathogen especially associated with nosocomial infections, yielding four potential hits. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SA/CMCS hydrogel was cross-linked by calcium ions provided by the sustained release system consisting of d-glucono-δ-lactone (GDL) and superfine calcium carbonate (CaCO(3)), and the conductivity of the hydrogel was provided by doped with polypyrrole (PPy). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Abamectin, produced by the soil-dwelling actinomycete Streptomyces avermitilis, belongs to the macrocyclic lactones class of pesticides, has nematocidal, acaricidal, and insecticidal activity, and is highly effective when used against targeted species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The present work aims at summarizing the current knowledge on antitumor hybrids built using 1,4- and 1,2-naphthoquinone (present in natural compounds as lawsone, napabucasin, plumbagin, lapachol, α-lapachone, and β -lapachone), and the related quinolone- and isoquinolinedione scaffolds reported in the literature up to 2021. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The reactivity of salicylaldehyde and hydroxynaphthaldehydes was tested; under these conditions, partially saturated lactones were formed through spontaneous ring closure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Lekethromycin (LKMS), a novel macrolide lactone, is still unclear regarding its absorption. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso