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7921por Olufs, Zachariah P. G., Loewen, Carin A., Ganetzky, Barry, Wassarman, David A., Perouansky, Misha“…We studied the VGAs isoflurane and sevoflurane in four wild type strains from the Drosophila Genetic Reference Panel, two commonly used laboratory strains (Canton S and w(1118)), and a mutant in Complex I of the mitochondrial electron transport chain (ND23(60114)). …”
Publicado 2018
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7922por Haripriyan, Jayalekshmi, Omanakuttan, Athira, Menon, Nitasha D., Vanuopadath, Muralidharan, Nair, Sudarslal Sadasivan, Corriden, Ross, Nair, Bipin G., Nizet, Victor, Kumar, Geetha B.“…LC-MS/MS analysis indicated that CBO treatment elicited a significant reduction of signalling molecules (Acyl-Homoserine-Lactone) involved in quorum sensing regulation. Our observations demonstrate that CBO attenuates key virulence mechanisms of this important human pathogen, while concomitantly enhancing host innate immunomodulatory functions, with potential implications for topical therapy against antibiotic-resistant infections.…”
Publicado 2018
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7923por Torres, Marta, Reina, José Carlos, Fuentes-Monteverde, Juan Carlos, Fernández, Gerardo, Rodríguez, Jaime, Jiménez, Carlos, Llamas, Inmaculada“…During recent years it has been shown that the expression of virulence genes in some Vibrio species is controlled by a population-density dependent gene-expression mechanism known as quorum sensing (QS), which is mediated by the diffusion of signal molecules such as N-acylhomoserine lactones (AHLs). QS disruption, especially the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), is one of the novel therapeutic strategies for the treatment of bacterial infections. …”
Publicado 2018
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7924por Sanchez, Elena, Artuso, Emma, Lombardi, Chiara, Visentin, Ivan, Lace, Beatrice, Saeed, Wajeeha, Lolli, Marco L, Kobauri, Piermichele, Ali, Zahid, spyrakis, Francesca, Cubas, Pilar, Cardinale, Francesca, Prandi, Cristina“…The results also showed that modification of the butenolide ring into a lactam one significantly hampers the biological activity exhibited by SLs possessing a canonical lactonic D-ring.…”
Publicado 2018
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7925“…In this context, we review the main advances in the field of QS in S. maltophilia by paying special attention to Diffusible Signal Factor (DSF) signaling, Acyl Homoserine Lactone (AHL) responses and the controversial Ax21 system. …”
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7926“…Parameters taken into account were: pH, electrical conductivity, ash, free acidity, lactonic acidity, total acidity, moisture content, total sugars (degrees Brix-°Bx), total dissolved solids and their ratio to total acidity, salinity, CIELAB color parameters, along with browning index values. …”
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7927por Salgado, Francisco, Albornoz, Laura, Cortéz, Carmen, Stashenko, Elena, Urrea-Vallejo, Kelly, Nagles, Edgar, Galicia-Virviescas, Cesar, Cornejo, Alberto, Ardiles, Alejandro, Simirgiotis, Mario, García-Beltrán, Olimpo, Areche, Carlos“…The phytochemistry of the Usnea genus includes more than 60 compounds which belong to the following classes: depsides, depsidones, depsones, lactones, quinones, phenolics, polysaccharides, fatty acids and dibenzofurans. …”
Publicado 2017
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7928por Wanner, Miriam, Matthes, Katarina L., Korol, Dimitri, Dehler, Silvia, Rohrmann, Sabine“…We extracted all malignant cancer cases (excluding non-melanoma skin cancer) diagnosed between 1980 and 2014 in the canton of Zurich. Methods included the proportion of morphologically verified cases (MV%), the proportion of DCN and DCO cases (2009–2014), cases with primary site uncertain (PSU%), the stability of incidence rates over time, age-specific incidence rates for childhood cancer, and mortality:incidence (MI) ratios. …”
Publicado 2018
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7929por Trimigno, Alessia, Münger, Linda, Picone, Gianfranco, Freiburghaus, Carola, Pimentel, Grégory, Vionnet, Nathalie, Pralong, François, Capozzi, Francesco, Badertscher, René, Vergères, Guy“…A multivariate analysis of the untargeted serum metabolomes, combined with a targeted analysis of candidate FIBs previously reported in urine samples from the same study, identified galactitol, galactonate, and galactono-1,5-lactone (milk), 3-phenyllactic acid (cheese), and pinitol (soy drink) as candidate FIBs for these products. …”
Publicado 2018
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7930por Zhang, Jianping, Yuan, Bochuan, Liu, Dong, Gao, Shuang, Proksch, Peter, Lin, Wenhan“…Brasilianoids A and F showed an unprecedented skeleton with a γ-lactone in ring A, while brasilianoids B–C featured a 7/6/6/5/5 pentacyclic ring system finding in nature for the first time. …”
Publicado 2018
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7931por Maroyi, Alfred“…Phytochemical studies revealed the presence in VI of fatty acids, flavonoids, iridoid lactones and triterpenoids. Based on in vitro and animal studies, the species exhibited antibacterial, antimycobacterial, antifungal, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, antifeedant and prostaglandin synthesis inhibitory activities. …”
Publicado 2018
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7932por Kozłowska, Ewa, Urbaniak, Monika, Hoc, Natalia, Grzeszczuk, Jakub, Dymarska, Monika, Stępień, Łukasz, Pląskowska, Elżbieta, Kostrzewa-Susłow, Edyta, Janeczko, Tomasz“…Hydroxylations at the 7α or 11α position and oxidation to D-homo lactones are described in the literature. In our study, we examined the diversity of metabolism of five different B. bassiana strains and compared them to already known pathways. …”
Publicado 2018
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7933“…Methods: A high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS) method with electrospray ionization was developed to measure the herbal biomarkers of guanosine, atractylenolide III, glycyrrhizic acid, dehydrocostus lactone, hesperidin, and oleanolic acid from XSLJZT. …”
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7934“…Deoxyelephantopin (DET) and isodeoxyelephantopin (IDET) are sesquiterpene lactone components of “Elephantopus scaber and Elephantopus carolinianus”, traditional Chinese medicinal herbs that have long been used as folk medicines to treat liver diseases, diabetes, diuresis, bronchitis, fever, diarrhea, dysentery, cancer, and inflammation. …”
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7935por Brentan Silva, Denise, Aschenbrenner, Anna-Katharina, Lopes, Norberto Peporine, Spring, Otmar“…Herein, we analyzed sesquiterpene lactones, present in CGT, from leaf transversal sections using the matrix 2,5-dihydroxybenzoic acid (DHB) and α-cyano-4-hydroxycinnamic acid (CHCA) (mixture 1:1) with sodium ions added to increase the ionization in positive ion mode. …”
Publicado 2017
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7936por Verdú, José R., Cortez, Vieyle, Martinez-Pinna, Juan, Ortiz, Antonio J., Lumaret, Jean-Pierre, Lobo, Jorge M., Sánchez-Piñero, Francisco, Numa, Catherine“…Among macrocyclic lactones (ML), ivermectin (IVM) and moxidectin (MOX) potentially affect all Ecdysozoan species, with dung beetles being particularly sensitive. …”
Publicado 2018
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7937por Iranshahi, Mehrdad, Rezaee, Ramin, Najaf Najafi, Mona, Haghbin, Ali, Kasaian, Jamal“…This genus is a rich source of biologically active phytochemicals such as sulfur-containing derivatives, coumarins, sesquiterpenes, sesquiterpene lactones, sesquiterpene coumarins, glucuronic acid, galactose, arabinose, rhamnose, and daucane esters. …”
Publicado 2018
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7938por Shakhparonov, M. I., Antipova, N. V., Shender, V. O., Shnaider, P. V., Arapidi, G. P., Pestov, N. B., Pavlyukov, M. S.“…PON2 belongs to the paraoxonase protein family that consists of lactone hydrolyzing enzymes with different substrate specificities. …”
Publicado 2018
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7939por Pilija, Vladimir, Mirjana, Radenkovic, Brenesel, Maja Djurendic, Popovic, Mira, Ivetic, Vesna, Trivic, Svetlana“…Тhe effects of Gingium® - a standardized ginkgo biloba extract (GBE) [one milliliter preparation contained 8.8–10.8 mg ginkgo flavonol glycoside and 2.0–2.8 mg lactone ring-containing terpenes (ginkgolides and bilobalides)], on the tonus of isolated segments of the ileum and the colon of rabbits were examined. …”
Publicado 2010
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7940por Mamoci, Erjon, Cavoski, Ivana, Simeone, Vito, Mondelli, Donato, Al-Bitar, Lina, Caboni, Pierluigi“…The chemical compositions of the extracts were analyzed by HPLC-DAD, LC-MS (ESI) and LC-Q-TOF techniques. Two sesquiterpene lactones (inuviscolide, tomentosin) and three sesquiterpene acids (costic acid, hydroxycostic acid, ilicic acid) were identified from the D. viscosa extract, while in F. communis extracts three daucane sesquiterpenes (acetoxyferutinin, oxojaeskeanadioyl anisate, fertidin) and one coumarin (ferulenol) derivates were found. …”
Publicado 2011
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