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  1. 7981
    “…Additionally, a number of related resorcyclic acid lactones (RALs) were putatively identified, namely pochonins and several additional derivatives of radicicol. …”
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    Metabolomic Profiling of Fungal Pathogens Responsible for Root Rot in American Ginseng
  2. 7982
    “…We detected QQ activity, involving enzymatic degradation of signal molecules in quorum sensing communication systems, against a broad range of N-acylhomoserine lactones (AHLs). HPLC-MRM data and phylogenetic analysis indicated that the QQ enzyme was an acylase. …”
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    Plant growth-promoting activity and quorum quenching-mediated biocontrol of bacterial phytopathogens by Pseudomonas segetis strain P6
  3. 7983
    “…Thermal-tolerant lettuce cultivar accumulated higher concentrations of amino acids, organic acids, sugars, sesquiterpene lactones, sterols, and fatty acids derivatives during the germination at 35 °C compared to germinated at 21 °C. …”
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    Distinct Metabolome Changes during Seed Germination of Lettuce (Lactuca sativa L.) in Response to Thermal Stress as Revealed by Untargeted Metabolomics Analysis
  4. 7984
    “…S-components of the leukocidins Panton-Valentine leukocidin (PVL), γ-haemolysin AB (HlgAB) and CB (HlgCB), and leukocidin ED (LukED) specifically employ receptors that belong to the class of G-protein coupled receptors (GPCRs). …”
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    Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity
  5. 7985
    “…The generation of HCl resulting from lactone formation could be an additional problem for organometallic photoredox catalysts used in this reaction. …”
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    Visible-light-induced addition of carboxymethanide to styrene from monochloroacetic acid
  6. 7986
    “…Since the discovery of the archetype withaferin A in 1965, approximately 900 of these naturally occurring, polyoxygenated steroidal lactones with 28-carbon ergostane skeletons have been discovered across 24 diverse structural types. …”
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    Natural Withanolides in the Treatment of Chronic Diseases
  7. 7987
    “…Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. …”
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    Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa
  8. 7988
    “…Even though still heavily debated, clinical and epidemiological studies suggest the involvement of one of the bi-component toxin, Panton-Valentine Leukocidin (PVL), as an important factor contributing to the epidemic spread and increased virulence of CA-MRSA strains. …”
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    Studying Staphylococcal Leukocidins: A Challenging Endeavor
  9. 7989
    “…Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. …”
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    Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases
  10. 7990
    “…A heatmap emphasized the 19 most discriminant key odorants, among which heterocyclic molecules (furanones, pyranones, lactones, one pyrrole, and one pyrazine) played a prominent role with secondary alcohols, acids, and esters. …”
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    Key Aroma Compounds of Dark Chocolates Differing in Organoleptic Properties: A GC-O Comparative Study
  11. 7991
    “…The former is associated with its self-lactonization, serving as an improvised intermediate state of Ami hydrolysis. …”
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    Deep Functional Profiling Facilitates the Evaluation of the Antibacterial Potential of the Antibiotic Amicoumacin
  12. 7992
    “…Third-generation poly(amidoamine) dendrimer (PAMAM) was modified by stepwise primary amine group amidation with d-glucoheptono-1,4-lactone. The physicochemical properties of the conjugates—size, ζ potential in lysosomal pH 5 and in neutral aqueous solutions, as well as intramolecular dynamics by differential scanning calorimetry—were determined. …”
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    Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates
  13. 7993
    “…Among the 2487 FDA-approved compounds tested, anthelmintic agents of the class of macrocyclic lactones exhibited potent anti-leukemia activity, similar to the already known anti-leukemia agents currently used in induction chemotherapy. …”
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    Repurposing anthelmintic agents to eradicate resistant leukemia
  14. 7994
    “…Prevention therapy against Dirofilaria immitis in companion animals is currently threatened by the emergence of isolates resistant to macrocyclic lactone anthelmintics. Understanding the control over developmental processes in D. immitis is important for elucidating new approaches to heartworm control. …”
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    The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12
  15. 7995
    “…Despite good career prospects, there is a desire among young colleagues for cantonal practice assistance and mentoring programs, as well as support in finding a job and in taking the plunge into self-employment.…”
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    Career Prospects of Young Dentists in Switzerland
  16. 7996
    “…Furthermore, the high concentration of sesquiterpene lactones in capitate glandular trichomes and the restricted presence of certain flavonoids and caffeic acid esters in underground organs and internal tissues suggests that these metabolites could be involved in protective and ecological functions. …”
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    Metabolomic and Gene Expression Studies Reveal the Diversity, Distribution and Spatial Regulation of the Specialized Metabolism of Yacón (Smallanthus sonchifolius, Asteraceae)
  17. 7997
    “…Pyrethroids, organophosphates, carbamates, and macrocyclic lactones are licensed acaricides for use in China, Japan, and India. …”
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    Parasitic Mite Fauna in Asian Poultry Farming Systems
  18. 7998
    por Straughn, Alex R., Kakar, Sham S.
    Publicado 2020
    “…Interestingly, two independent research groups have discovered that Withaferin A (WFA), a steroidal lactone with anti-inflammatory and anti-tumorigenic properties, may bind to the viral spike (S-) protein of SARS-CoV-2. …”
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    Withaferin A: a potential therapeutic agent against COVID-19 infection
  19. 7999
    “…The proportion of isolates carrying Panton–Valentine leucocidin (PVL)-associated genes increased from 3.4% to 59.8% (χ(2) test for trend 7021.9, P < 0.001). …”
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    Marked increase in community-associated methicillin-resistant Staphylococcus aureus infections, Western Australia, 2004–2018
  20. 8000
    “…BACKGROUND: Prophylactic anthelmintic treatment with one of three basic classes of anthelmintics (benzimidazoles, macrocyclic lactones and imidazothiazoles) is still the mainstay of control of gastrointestinal nematode infections in small ruminants worldwide. …”
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    The first report of multidrug resistance in gastrointestinal nematodes in goat population in Poland
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