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  1. 8281
    por Chen, Lianguo, Qian, Pei-Yuan
    Publicado 2017
    “…Several molecular targets show good potential for use as biomarkers in future mechanistic screening, such as acetylcholine esterase for neurotransmission, phenoloxidase/tyrosinase for the formation of adhesive plaques, N-acyl homoserine lactone for quorum sensing and intracellular Ca(2+) levels as second messenger. …”
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    Review on Molecular Mechanisms of Antifouling Compounds: An Update since 2012
  2. 8282
    “…We report that blocking protein degradation with the proteasome inhibitor clasto-lactacystin β-lactone (βLac) or blocking protein synthesis with anisomycin (ANI) immediately after context preexposure significantly impaired context memory formation. …”
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    Context memory formation requires activity-dependent protein degradation in the hippocampus
  3. 8283
    “…Santamarine (STM), a sesquiterpene lactone component of Magnolia grandiflora and Ambrosia confertiflora, has been shown to possess antimicrobial, antifungal, antibacterial, anti-inflammatory, and anticancer activities. …”
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    Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress
  4. 8284
    “…The goal of this study was to assess the ability of oxycodone DETERx (Xtampza(®) ER, Collegium Pharmaceutical, Inc., Canton, MA, USA) and other commercially available ER opioid formulations with and without physicochemical abuse-deterrent characteristics to be manipulated by crushing in an in vitro setting. …”
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    In Vitro Drug Release After Crushing: Evaluation of Xtampza(®) ER and Other ER Opioid Formulations
  5. 8285
    “…Setting Surgery ward focused on vascular and visceral surgery at a Swiss Cantonal Hospital. Method The study was divided into two phases, before and after implementation of an IT-guided checklist. …”
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    Implementation of an IT-guided checklist to improve the quality of medication history records at hospital admission
  6. 8286
    “…CGT can produce various secondary metabolites such as sesquiterpene lactones (STLs) and provide durable resistance to insect pests. …”
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    Genetic Architecture of Capitate Glandular Trichome Density in Florets of Domesticated Sunflower (Helianthus annuus L.)
  7. 8287
    “…Evidence is presented that aryl β-keto esters may act as antagonists of bacterial quorum sensing by competing with N-acyl homoserine lactones for receptor binding. Expansion of the β-keto ester panel will enable us to obtain more insight into the structure–activity relationships needed to allow for the development of novel anti-virulence agents.…”
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    Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters
  8. 8288
    “…Sesquiterpene lactones (STLs) are a class of plant secondary metabolites widely found in nature with potent antitumor activities. …”
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    Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents
  9. 8289
    “…All isolates (both MRSA and methicillin-sensitive S. aureus) were Panton–Valentine leucocidin-negative, and 56.7% harbored egc genes. …”
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    Emergence and spread of worldwide Staphylococcus aureus clones among cystic fibrosis patients
  10. 8290
    “…Although the synaptic areas in eag(1);nwk(2) boutons were not significantly different from those of nwk(2), the number of SVs in the RRPs was similar to those of Canton-S. In addition, three-dimensional, high-voltage EM tomographic analysis demonstrated that significantly fewer enlarged SVs were present in nwk(2) RRPs. …”
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    Regulation of synaptic architecture and synaptic vesicle pools by Nervous wreck at Drosophila Type 1b glutamatergic synapses
  11. 8291
    “…The activities of CPT‐11 and SN‐38 depend on the closed lactone ring form of SN‐38. We have examined the tissue distributions of the closed and open forms of CPT‐11 and SN‐38 in Lewis lung carcinoma‐bearing mice after the administration of liposomal CPT‐11 (S‐Lip) and polyethyleneglycol (PEG)‐modified S‐Lip (S‐PEG). …”
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    Effective Irinotecan (CPT‐11)‐containing Liposomes: Intraliposomal Conversion to the Active Metabolite SN‐38
  12. 8292
    “…METHODS: This retrospective analysis was conducted in the Department of Internal Medicine, Uster Hospital, Canton of Zurich, Switzerland. Patients hospitalized in the 3 months before and after implementation were analyzed. …”
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    An echo to Choosing Wisely(®) in Switzerland
  13. 8293
    “…In the following research, we have isolated the sesquiterpene lactone achillolide A from the plant Achillea fragrantissima and, for the first time, characterized its effects on Aβ-treated neuroblastoma cells. …”
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    β-amyloid cytotoxicity is prevented by natural achillolide A
  14. 8294
    “…ETHICS AND DISSEMINATION: The Human Research Ethics Committee of the Canton Vaud (CER-VD) has certified that this research study protocol falls outside of the field of application of the Swiss Federal Act on Research Involving Humans. …”
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    Protection of pregnant women at work in Switzerland: practices, obstacles and resources. A mixed-methods study protocol
  15. 8295
    “…We used all lung cancer cases recorded between 1995 and 2013 by two population-based cancer registries in the contiguous cantons of Vaud and Valais, in Western Switzerland. …”
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    Estimating lifetime and 10-year risk of lung cancer()
  16. 8296
    “…Baeyer–Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. …”
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    Improving catalytic activity of the Baeyer–Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy)undec-9-enoic acid from ricinoleic acid
  17. 8297
    “…RESULTS: Using reaction engineering, the reaction rate and product formation of the regio‐isomeric branched lactones were improved and the use of co‐solvents and the initial substrate load were investigated. …”
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    Application of a thermostable Baeyer–Villiger monooxygenase for the synthesis of branched polyester precursors
  18. 8298
    “…A total of 32 volatile compounds consisting of different chemical classes acids (13), alcohols (7), phenols (3), terpene (1), esters (2), ketones (2), aldehyde (1), lactone (1) and hydrocarbons (2) were determined. …”
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    Characterization of Aroma-Active Compounds in Seed Extract of Black Cumin (Nigella sativa L.) by Aroma Extract Dilution Analysis
  19. 8299
    “…Exogenous N-butanoyl-l-homoserine lactone could remedy the electricity production by lasIrhlI mutants to a level similar to wild-type strains while signaling molecules had little effect on wild-type bacteria in MFCs. …”
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    Dual-Edged Character of Quorum Sensing Signaling Molecules in Microbial Extracellular Electron Transfer
  20. 8300
    “…Asteriscus graveolens (A. graveolens) plants contain among other metabolites, sesquiterpene lactone asteriscunolide isomers (AS). The crude extract and its fractions affected the viability of mouse BS-24-1 lymphoma cells (BS-24-1 cells) with an IC50 of 3 μg/mL. …”
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    Molecular Mode of Action of Asteriscus graveolens as an Anticancer Agent
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