“…In many of the plant-associated isolates of Serratia and Burkholderia, production of PRN is dependent on the quorum-sensing regulation that usually involves N-acylhomoserine lactone (AHL) autoinducer signals. When applied on the organisms as antimicrobial agent, the molecule impedes synthesis of key biomolecules (DNA, RNA and protein), uncouples with oxidative phosphorylation, inhibits mitotic division and hampers several biological mechanisms. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…More precisely, in this disease, the painless skin ulcers are caused by mycolactone, a polyketide lactone exotoxin. In fact, mycolactone exerts a wide range of effects on the host, besides being responsible for analgesia, as it has been shown notably to modulate the immune response or to provoke apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, on 27 farms (n=306 animals), a FECR test was conducted after oral formulations of a macrocyclic lactone (ML), benzimidazole (BZ) (partly in combination with salicylanilide (SA)) or a combination of imidazothiazole and SA were applied under controlled conditions on the same farm. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This element was identified in CC30 MRSA from Kuwait, Saudi Arabia and the United Arab Emirates that usually also harbour the Panton-Valentin leukocidin (PVL) genes. It was also identified in CC8 and ST834 isolates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In post-industrial cities formed by historical and ongoing processes of structural inequality such as Detroit, Michigan, gardening is beneficial for residents in terms of health, economic activity, community-building, and city beautification (Lawson 2005; Pitt 2014; Pothukuchi 2015; White 2011). …”
Enlace del recurso
Enlace del recurso

“…Alantolactone (ALA) is a sesquiterpene lactone with potent anti-inflammatory activity. However, the effect of ALA on intestinal inflammation remains largely unknown. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Tandem Mass Spectrometric analysis revealed the presence of various secondary metabolites, i.e., a series of known as well as novel N-acyl-homoserine lactones, several homologues of 4-hydroxy-2-alkylquinolines, and rhamnolipids, which are the signature metabolites of Pseudomonas species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…10-deoxoartemisinin is a semisynthetic derivative of artemisinin that lacks a lactone carbonyl group at the 10-position, and has stronger antimalarial properties than artemisinin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The process of adsorption of methyl (MePB) and ethylparaben (EtPB) from aqueous solution on the activated carbons at 18 °C was studied and related to the interactions between the adsorbate and the adsorbent, which can be quantified through the determination of immersion enthalpies in aqueous solutions of corresponding paraben, showing the lowest-value carbon GM2, which has a surface area of 608 m(2) × g(−1), while the highest values correspond to the activated carbon GCu2, with a surface area of 896 m(2) × g(−1) and the highest content of surface acid sites (0.42 mmol × g(−1)), such as lactonic and phenolic compounds, which indicates that the adsorbate–adsorbent interactions are favored by the presence of these, with interaction enthalpies that vary between 5.72 and 51.95 J × g(−1) for MePB adsorption and 1.24 and 52.38 J × g(−1) for EtPB adsorption showing that the process is endothermic.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The concentration of the defensive sesquiterpene lactone taraxinic acid β-D glucopyranosyl ester (TA-G) varied substantially over the year and was most strongly correlated to mean monthly temperature. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thanks to this multi-technique approach, based on complementary analytical tools and computational support, it was possible to conclude that, in addition to the major linear unconjugated polymerization, the PFA structure consists of Diels-Alder rearrangements occurring after the opening of some furanic units, while the terminal moieties of the chain involves γ-lactone arrangements. The occurrence of head-head methylene ether bridges and free hydroxyl groups (from unreacted furfuryl alcohol, FA, or terminal chains) could be excluded, while the conjugated systems could be considered rather limited.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, we revealed strain-specific production of siderophores and homoserine lactones, with implications for nutrient acquisition and cellular communication. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, an alternative strategy, such as macrocyclic lactone in combination with a tetracycline antibiotic, has to be used. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The overall prevalence of Panton‐Valentine leukocidin genes among S. aureus isolates was 21.4% (15/70), and 27 different spa types were identified. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In rhizobia, QS systems usually relies on the synthesis and detection of N-acyl-homoserine lactones (AHLs). In the model bacterium Sinorhizobium meliloti functions regulated by the QS systems TraI-TraR and SinI-SinR(-ExpR) include plasmid transfer, production of surface polysaccharides, motility, growth rate and nodulation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Yamaguchi esterification and intramolecular Horner–Wadsworth–Emmons condensation were used as key reactions to construct the lactone core. The chiral centers at C17 and C18 were introduced by the Sharpless asymmetric dihydroxylation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: To expand the chemical space and explore their inhibitory activities against α-glucosidase (EC 3.2.1.20), we employed β-caryophyllene and some natural moieties (4-hydroxycoumarins, lawsone or syncarpic acid) to synthesize new types of meroterpene-like skeletons. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A large number of volatile compounds, including carboxylic acids, lactones, ketones, alcohols, and aldehydes, can be detected in cheese. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The concentration of fermentation products was highest in varietal wines, while long-term matured Tokaj special wines were typified by the presence of compounds related to noble-rotten raisins (2-phenylacetaldehyde, ethyl 2-phenylacetate, and 2-phenylethanol), wood (cis-whisky lactone), and aging (1,1,6-trimethyl-2H-naphthalene, furfural, and 5-methylfurfural).…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…2α-Hydroxyeudesma-4,11(13)-dien-8β,12-olide (HEDO), a eudesmane-type sesquiterpene lactone belonging to large group of plant terpenoids isolated from Inula britannica, displays cytotoxic activity against diffuse large B cell lymphoma cells in vitro. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso