“…This study aimed to evaluate the interaction of artemisinin, a sesquiterpene lactone extracted from the Artemisia genus, and its derivatives with the SARS-CoV-2 main protease. …”
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“…TRIAL REGISTRATION: The protocol was approved by the Ethics Committee of the Canton Bern (ProjectID: 2018–00461). Trial registration is intended at ClinicalTrials.gov.…”
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“…Using a cross-sectional study design, an anonymous questionnaire was sent to a random sample of 1′000 PCPs practicing in the seven Western cantons of Switzerland. In our sample, we assessed the presence of five lifestyle risk factors, namely current smoking, at risk alcohol consumption, insufficient physical activity, being overweight and insufficient hours of sleep. 510 physicians participated in our study (51% participation rate). …”
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“…The reactivity of these norbornyl complexes depends on the substituents on the inserted alkenyl fragment, and thus they can further react with (1) KO(t)Bu, to give Pd(0) and a tetrahydroisoquinoline nucleus containing a tricyclo[3.2.1]octyl ring, or (2) CO and TlOTf, to afford Pd(0) and amino acid derivatives or the corresponding lactones arising from an intramolecular Michael addition of the CO(2)H group to the α,β-unsaturated ester moiety. …”
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“…Alongside well-known biotransformation pathways in plants, additional novel pathways were suggested, namely, conjugation with sesquiterpene lactones, and abscisic acid as a part of phase II of plant metabolism. …”
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“…The results showed that mannitol modification slightly decreased the S(BET) (5.30% of PAAC) and increased the content of carboxyl, lactone, and phenolic groups (total increase of 43.96% with PAAC), which enhanced the adsorption capacity of PAAC by 58.59%. …”
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“…Nine-carbon aldehyde and alcohol compounds dominated both the flesh and rind, though the rind lacked the diversity of other aldehydes, alcohols, ketones, terpenes, terpenoids, esters and lactones that were more abundant in the watermelon flesh. …”
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“…ETHICS AND DISSEMINATION: The independent research ethics committee of Canton Zurich confirmed that ethical approval for this PPI subproject was not required. …”
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“…Melampomagnolide B (MMB) is a natural sesquiterpene lactone product structurally related to parthenolide (PTL). …”
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“…Brevilin A, a natural sesquiterpene lactone extracted from Centipeda minima, has been found to exhibit anti-tumor effect. …”
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“…We used data collected between autumn 2020 and spring 2021 from 844 participants aged 5 to 19 of a population-based, prospective cohort study in Canton Ticino, Italian-speaking Switzerland. We analyzed the data using an extended version of the Random Intercept Cross-Lagged Panel Model with time-invariant socio-demographic covariates and mental health as outcome. …”
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“…Liquid chromatography–tandem high-resolution mass spectrometry (LC-HRMS/MS) analysis of methanol and chloroform extracts obtained from the roots and aerial parts of the plants led to the identification of 15 phenolic acids (mostly hydroxycinnamic acid derivatives), 26 flavonoids (poly-hydroxylated/poly-methoxylated flavone derivatives, present only in the aerial parts), 14 sesquiterpene lactones, 3 coumarins, 1 lignan and 7 fatty acids. …”
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“…In the present study, micheliolide (MCL), a natural guaianolide sesquiterpene lactone, was screened out by the virtual screening strategies, identified as an inhibitor of thioredoxin reductase (TrxR) and was evaluated to have high potential to induce ICD. …”
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“…The impacts of disruptive events that could affect each road section will be analyzed using the criticality of the high capacity road network in Spain under different policymaking scenarios, such as direct democracy based on pure provincial decentralization (federal or cantonal vision), representative democracy in which decisions are taken by the National Parliament, and the governance based on technocracy stimulated by ‘what matters is what works’ (Southern Local Economy, 16(4), 264-271, 2001) using an Evidence-Based Policy Making (EBPM) case study based on a Data Envelopment Analysis applied to four accessibility indicators. …”
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“…VERIFY, an observational method, is one of the key elements in a procedure adopted by the police of the canton of Zurich, Switzerland, for detecting impaired drivers. …”
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“…MATERIAL AND METHODS: Antimicrobial, anabolic hormone, lactone, β-agonist, mycotoxin and pesticide residues were analysed in 120 raw milk samples from different dairy farms in North Macedonia. …”
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“…A total of 17 high schools in the Canton of Zurich, Switzerland, circulated the survey among their students. …”
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“…The ratio of pitavastatin lactone AUC(0‐∞) to pitavastatin AUC(0‐∞) was also comparable between treatments. …”
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“…OBJECTIVES: To explore the perspectives of health care providers and authorities in Canton Bern on the utility of a COVID-19 OFTT, as well as elicit recommendations for telehealth in future. …”
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“…This review also describes the chemical structure of 232 NPs presenting anti-CRC activity with the being majority of quinones, lactones, alkaloids, peptides, and glycosides. The study reveals that most of these NPs are derived from marine actinobacteria followed by terrestrial and endophytic actinobacteria, respectively. …”
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