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1161por Rudroff, Florian, Fink, Michael J., Pydi, Ramana, Bornscheuer, Uwe T., Mihovilovic, Marko D.“…We demonstrated the applicability of the title enzymes in the enantioselective synthesis of (R)-(−)-Taniguchi lactone, a building block for the preparation of various natural product analogs such as ent-quinine. …”
Publicado 2016
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1162“…Various membrane receptors associated with the innate immune response have recently been identified as mediators of the cellular action of Staphylococcus aureus leucotoxins. Two of these, the Panton–Valentine leucotoxin LukS-PV/LukF-PV and the γ-hemolysin HlgC/HlgB, bind the C5a complement-derived peptide receptor. …”
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1163por Rodríguez-Ruiz, Marta, Mateos, Rosa M., Codesido, Verónica, Corpas, Francisco J., Palma, José M.“…In plants, ascorbic acid is mainly synthesized through the L-galactose pathway, being the L-galactono-1,4-lactone dehydrogenase (GalLDH) the last step. Using pepper fruits, the full GalLDH gene was cloned and the protein molecular characterization accomplished. …”
Publicado 2017
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1164“…In the title compound, C(15)H(16)O(6), obtained from the acylation reaction between 2,3-O-isopropylidene-d-ribono-1,4-lactone and benzoyl chloride, the known absolute configuration for the lactone moiety of the ester substituent has been confirmed. …”
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1165por Girard, Léa, Blanchet, Élodie, Intertaglia, Laurent, Baudart, Julia, Stien, Didier, Suzuki, Marcelino, Lebaron, Philippe, Lami, Raphaël“…Since the discovery of quorum sensing (QS) in the 1970s, many studies have demonstrated that Vibrio species coordinate activities such as biofilm formation, virulence, pathogenesis, and bioluminescence, through a large group of molecules called N-acyl homoserine lactones (AHLs). However, despite the extensive knowledge on the involved molecules and the biological processes controlled by QS in a few selected Vibrio strains, less is known about the overall diversity of AHLs produced by a broader range of environmental strains. …”
Publicado 2017
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1166por de Oliveira Mauro, Mariana, Matuo, Renata, de David, Natan, Strapasson, Regiane Lauriano Batista, Oliveira, Rodrigo Juliano, Stefanello, Maria Élida Alves, Kassuya, Cândida Aparecida Leite, de Cepa Matos, Maria de Fátima, Faria, Fábio José Carvalho, Costa, Deiler Sampaio“…The aim of this study was to evaluate the cytotoxic, apoptotic and (anti)proliferative potential of two sesquiterpene lactones isolated from Moquiniastrum polymorphum, 11,13-diidrozaluzanin C (1) and gochnatiolide C (2), and their associations with chemotherapeutic agents irinotecan, tamoxifen, cisplatin, 5-fluouracyl and doxorubicin in the tumoral lineage of MCF-7 breast adenocarcinoma. …”
Publicado 2017
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1167por Balhouse, Brittany N., Patterson, Logan, Schmelz, Eva M., Slade, Daniel J., Verbridge, Scott S.“…To test this, we incubated human breast adenocarcinoma cells (MDA-MB-231, MCF-DCIS.com) and non-malignant breast epithelial cells (MCF-10A) with N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL), a quorum-sensing molecule from Pseudomonas aeruginosa that regulates bacterial stress responses. …”
Publicado 2017
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1168por Lohans, Christopher T., van Groesen, Emma, Kumar, Kiran, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.“…We show that class D β‐lactamases also degrade clinically used 1β‐methyl‐substituted carbapenems through the unprecedented formation of a carbapenem‐derived β‐lactone. β‐Lactone formation results from nucleophilic attack of the carbapenem hydroxyethyl side chain on the ester carbonyl of the acyl‐enzyme intermediate. …”
Publicado 2018
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1169“…And cell model of epilepsy was established by coriaria lactone (CL)-stimulated HM cell, and the same factors were measured. …”
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1171por Skrobiszewski, Andrzej, Gładkowski, Witold, Mazur, Marcelina, Szczepanik, Maryla, Maciejewska, Gabriela, Wawrzeńczyk, Czesław“…Hydrolysis of (±)-β-aryl-γ-ethylidene-γ-lactones by fungal strain Aspergillus ochraceus AM370 afforded (−)-(S)-γ-ethylidene-γ-lactones 2a–d and (+)-(R)-γ-ketoacids 3a–d. …”
Publicado 2018
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1172por Herrera Acevedo, Chonny, Scotti, Luciana, Feitosa Alves, Mateus, Formiga Melo Diniz, Margareth De Fátima, Scotti, Marcus Tullius“…This review presents an survey to the biological importance of sesquiterpene lactones (SLs) in the fight against four infectious neglected tropical diseases (NTDs)—leishmaniasis, schistosomiasis, Chagas disease, and sleeping sickness—as alternatives to the current chemotherapies that display several problems such as low effectiveness, resistance, and high toxicity. …”
Publicado 2017
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1173“…BACKGROUND: Three patients hospitalised in the coronary care unit of a general district hospital (England, UK) were tested positive for Panton-Valentine leucocidin methicillin-resistant Staphylococcus aureus colonisation during their routine weekly screening for methicillin-resistant Staphylococcus aureus (MRSA). …”
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1174por Girard, Léa, Blanchet, Elodie, Stien, Didier, Baudart, Julia, Suzuki, Marcelino, Lami, RaphaëlEnlace del recurso
Publicado 2019
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1175por Filomena, Perri, Luca, Frattaruolo, Ian, Haworth, Matteo, Brindisi, Asma, El-magboub, Angela, Ferrario, Charles, Gomer, Francesca, Aiello, David, Adams James“…The aim of this study was to evaluate the anti-inflammatory activity of sesquiterpene lactones (SLs), representing the majority in the Asteraceae family. …”
Publicado 2019
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1176“…OBJECTIVES: To determine the epidemiological features of patients and animals after bites/scratches from rabies-suspected animals in Zenica-Doboj Canton, Bosnia and Herzegovina. METHODS: Data from all patients (and the causative animals) admitted to the Antirabies Service of the Institute for Health and Food Safety Zenica in the 2009-2017 period were analyzed, including age, sex, anatomical site of the bite/scratch, animal type (stray/owned/wildlife), veterinary observations of the animal, and whether antirabies post-exposure prophylaxis (PEP) was indicated and/or administered. …”
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1177“…The assay is able to perform identification of MRSA, Methicillin-Sensitive S. aureus, Methicillin-Resistant Coagulase Negative Staphylococci and the Panton-Valentine leukocidin virulence gene from rectal and pharyngeal swab samples in a screening context. …”
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1179“…This material and an additional Linton specimen compare favourably to ‘short-faced’ parareptiles, such as Colobomycter and Acleistorhinus, and justify recognition of an acleistorhinid parareptile in the Linton assemblage. …”
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1180por Mazur, Marcelina, Włoch, Aleksandra, Bahri, Fouad, Pruchnik, Hanna, Pawlak, Aleksandra, Obmińska-Mrukowicz, Bożena, Maciejewska, Gabriela, Gładkowski, Witold“…Starting from 1-acetyl-1-cyclohexene, three enantiomeric pairs (ee ≥ 99%) of bicyclic δ-halo-γ-lactones with cyclohexane ring were obtained in five-step synthesis. …”
Publicado 2020
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