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1661por Boonruang, Supattra, Prakobsri, Khanistha, Pouyfung, Phisit, Srisook, Ekaruth, Prasopthum, Aruna, Rongnoparut, Pornpimol, Sarapusit, Songklod“…In this study, activity-guided isolation identified four flavonoids 1–4 (apigenin, luteolin, chrysoeriol, quercetin) from Vernonia cinerea and Pluchea indica, four hirsutinolide-type sesquiterpene lactones 5–8 from V. cinerea, and acetylenic thiophenes 9–11 from P. indica that inhibited CYP2A6- and CYP2A13-mediated coumarin 7-hydroxylation. …”
Publicado 2017
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1662“…Studies aimed at a comparison of chemical, biomimetic (Gif system GoAgg(III)) and enzymatic (CHMO) transformations of natural (+)-10β,14-dihydroxy-allo-aromadendrane have led to preparation of an eight-member sesquiterpene lactone.…”
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1663por Nie, Yunjuan, Wang, Zhongxuan, Chai, Gaoshang, Xiong, Yue, Li, Boyu, Zhang, Hui, Xin, Ruiting, Qian, Xiaohang, Tang, Zihan, Wu, Jiajun, Zhao, Peng“…In this study we investigated the effects of dehydrocostus lactone (DHL), a natural sesquiterpene, on macrophage activation and LPS-induced ALI. …”
Publicado 2019
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1664“…A. hydrophila possesses an N-acyl homoserine lactone (AHL)-based quorum-sensing (QS) system that regulates virulence, so quorum signal-inactivation (i.e., QQ) may represent a new way to combat A. hydrophila infection. …”
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1665por Verma, Sumit S., Rai, Vipin, Awasthee, Nikee, Dhasmana, Anupam, Rajalaksmi, Dhanya S, Nair, Mangalam S., Gupta, Subash C.“…The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET) are known to exhibit activities against some cancer types. …”
Publicado 2019
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1666por Elshafie, Hazem S., Devescovi, Giulia, Venturi, Vittorio, Camele, Ippolito, Bufo, Sabino A.“…Burkholderia gladioli pv. agaricicola (Bga) possess promising biological activities regulated by N-Acyl homoserine lactones (N.AHLs) based quorum sensing (QS) mechanism. …”
Publicado 2019
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1667por Hosoe, Ayaka, Suenaga, Toshikazu, Sugi, Takumi, Iizumi, Taro, Nagai, Naohiro, Terada, Akihiko“…The strain, isolated from a paper mill, harbors the hdtS gene, encoding N-acyl-homoserine lactone synthase. Deciphering the genome contributes to revealing the mechanisms of quorum sensing and associated biofilm formation in engineered systems.…”
Publicado 2020
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1668por Qu, Zhao, Lin, Yushan, Mok, Daniel Kam-Wah, Bian, Qingya, Tai, William Chi-Shing, Chen, Sibao“…Brevilin A (BA), a natural sesquiterpene lactone, has been reported to exhibit anti-cancer effects. …”
Publicado 2020
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1669por Izumi, Clarice, Laure, Helen Julie, Barbosa, Nayara Gonçalves, Hassibe Thomé, Carolina, Aguiar Ferreira, Germano, Paulo Barreto Sousa, João, Peporine Lopes, Norberto, César Rosa, José“…In this work, we have screened six low molecular weight sesquiterpene lactones, isolated from Eremanthus spp., and studied their function as anti-proliferative agents against GBM strains. …”
Publicado 2020
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1670por Nawaz, Muhammad Shoib, Arshad, Ayesha, Rajput, Lubna, Fatima, Kaneez, Ullah, Sami, Ahmad, Muhammad, Imran, Asma“…The present study demonstrates the potential of acyl homoserine lactone (AHL)-producing plant growth promoting rhizobacteria (PGPR) strains of Aeromonas sp., namely, SAL-17 (accession no. …”
Publicado 2020
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1671por Guzman, John Paul Matthew D., De las Alas, Trisha Pamela L., Lucban, Margie C., Sevilla, Christine Eden C.“…In this study, four bacterial isolates from Pasig River, identified as Aeromonas salmonicida, Acinetobacter sp., Morganella morganii, and Citrobacter freundii, were observed to employ short-chain acyl homoserine lactone (AHL) as their signalling molecule based on in vitro assays using the biosensor strain Chromobacterium violaceum CV026. …”
Publicado 2020
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1672por Cvetanova, Biljana, Li, Meng-Yi, Yang, Chung-Chih, Hsiao, Pei-Wen, Yang, Yu-Chih, Feng, Jia-Hua, Shen, Ya-Ching, Nakagawa-Goto, Kyoko, Lee, Kuo-Hsiung, Shyur, Lie-Fen“…In this study, we created a lung-seeking A375LM5(IF4g/Luc) BRAF(V600E) mutant melanoma cell clone and investigated the bioefficacy of a plant sesquiterpene lactone deoxyelephantopin (DET) and its novel semi-synthetic derivative, DETD-35, in suppressing metastatic A375LM5(IF4g/Luc) melanoma growth in vitro and in a xenograft mouse model. …”
Publicado 2021
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1673por Chen, Zhiqian, Yang, Xiao, Zhou, Yifan, Liang, Zhihao, Chen, Chen, Han, Chen, Cao, Xiankun, He, Wenxin, Zhang, Kai, Qin, An, Zhou, Tangjun, Zhao, Jie“…The progression of intervertebral disc degeneration (IDD) is multifactorial with the senescence of nucleus pulposus (NP) cells and closely related to inflammation in NP cells. Dehydrocostus lactone (DHE) is a natural sesquiterpene lactone isolated from medicinal plants that has anti-inflammatory properties. …”
Publicado 2021
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1675por Eltom, Salah E. M., Abdellatif, Ahmed A. H., Maswadeh, Hamzah, Al-Omar, Mohsen S., Abdel-Hafez, Atef A., Mohammed, Hamdoon A., Agabein, Eiman ME., Alqasoomi, Ibrahim, Alrashidi, Salem A., Sajid, Mohammed S. M., Mobark, Mugahid A.“…The γ-lactone methylcellulose nanoparticles (γ-lactone-MC-NPs) were characterized for their size, shape, and encapsulation efficiency with a uniform size of 300 nm and 59.9% drug content. …”
Publicado 2021
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1676“…Quorum sensing of Acinetobacter nosocomialis for cell-to-cell communication produces N-3-hydroxy dodecanoyl-DL-homoserine lactone (OH-dDHL) by an AnoR/I two-component system. …”
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1677por Idres, Yanis A., Tousch, Didier, Cazals, Guillaume, Lebrun, Aurélien, Naceri, Sarah, Bidel, Luc P. R., Poucheret, Patrick“…Using chromatography and LC-MS—RMN, we then isolated and identified an original sesquiterpene lactone bioactive molecule: the Xanthatin-13-(pyrrolidine-2-carboxylic acid) (XPc). …”
Publicado 2021
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1678por Keeratichamroen, Siriporn, Lirdprapamongkol, Kriengsak, Thongnest, Sanit, Boonsombat, Jutatip, Chawengrum, Pornsuda, Sornprachum, Thiwaree, Sirirak, Jitnapa, Verathamjamras, Chris, Ornnork, Narittira, Ruchirawat, Somsak, Svasti, Jisnuson“…The present study demonstrated the anti-proliferative effect and apoptosis-inducing activity of three sesquiterpene lactones isolated from Gymnanthemum extensum, vernodalin (VDa), vernolepin (VLe) and vernolide (VLi), on A549 human lung cancer cells. …”
Publicado 2022
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1679por Sung, Kidon, Gudeta, Dereje D., Park, Miseon, Chon, Jungwhan, Kim, Sungguk, Nawaz, Mohamed S., Foley, Steven L., Khan, Saeed A.“…Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium responsible for difficult-to-treat staphylococcal infections due to multidrug resistance. Twelve Panton-Valentine leucocidin (PVL)-positive and multidrug-resistant clinical MRSA isolates from hospitals in Pakistan were sequenced and annotated to investigate genetic markers associated with antimicrobial resistance, virulence, and biofilm formation.…”
Publicado 2022
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1680por Rizzo, Stefania, Catanese, Carola, Puligheddu, Carla, Epistolio, Samantha, Ramelli, Giulia, Frattini, Milo, Pereira Mestre, Ricardo, Nadarajah, Navarajah, Rezzonico, Ermidio, Magoga, Francesco, Milan, Lisa, Del Grande, Filippo, Giovanella, Luca, Ceriani, Luca“…PURPOSE: The main objective of this study was to assess the presence of pulmonary infiltrates with computed tomography (CT) appearance compatible with infection by coronavirus disease 2019 (COVID-19), in Canton Ticino in the 2 months preceding the first official case. …”
Publicado 2022
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