Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

por Arnerić, Stephen P., Batrla-Utermann, Richard, Beckett, Laurel, Bittner, Tobias, Blennow, Kaj, Carter, Leslie, Dean, Robert, Engelborghs, Sebastiaan, Genius, Just, Gordon, Mark Forrest, Hitchcock, Janice, Kaplow, June, Luthman, Johan, Meibach, Richard, Raunig, David, Romero, Klaus, Samtani, Mahesh N., Savage, Mary, Shaw, Leslie, Stephenson, Diane, Umek, Robert M., Vanderstichele, Hugo, Willis, Brian, Yule, Susan
Publicado 2016

ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer’s disease

por Ko, Yi-An, Billheimer, Jeffrey T., Lyssenko, Nicholas N., Kueider-Paisley, Alexandra, Wolk, David A., Arnold, Steven E., Leung, Yuk Yee, Shaw, Leslie M., Trojanowski, John Q., Kaddurah-Daouk, Rima F., Kling, Mitchel A., Rader, Daniel J.
Publicado 2022

Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

por Vemuri, Prashanthi, Weigand, Stephen D., Przybelski, Scott A., Knopman, David S., Smith, Glenn E., Trojanowski, John Q., Shaw, Leslie M., Decarli, Charlie S., Carmichael, Owen, Bernstein, Matt A., Aisen, Paul S., Weiner, Michael, Petersen, Ronald C., Jack, Clifford R.
Publicado 2011

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

por Goel, Hira Lal, Pursell, Bryan, Chang, Cheng, Shaw, Leslie M, Mao, Junhao, Simin, Karl, Kumar, Prashant, Vander Kooi, Craig W, Shultz, Leonard D, Greiner, Dale L, Norum, Jens Henrik, Toftgard, Rune, Kuperwasser, Charlotte, Mercurio, Arthur M
Publicado 2013

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants

por Timmers, Maarten, Barão, Soraia, Van Broeck, Bianca, Tesseur, Ina, Slemmon, John, De Waepenaert, Katja, Bogert, Jennifer, Shaw, Leslie M., Engelborghs, Sebastiaan, Moechars, Dieder, Mercken, Marc, Van Nueten, Luc, Tritsmans, Luc, de Strooper, Bart, Streffer, Johannes Rolf
Publicado 2017

Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer’s disease

por Gangishetti, Umesh, Christina Howell, J., Perrin, Richard J., Louneva, Natalia, Watts, Kelly D., Kollhoff, Alexander, Grossman, Murray, Wolk, David A., Shaw, Leslie M., Morris, John C., Trojanowski, John Q., Fagan, Anne M., Arnold, Steven E., Hu, William T.
Publicado 2018

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

por Ewers, Michael, Biechele, Gloria, Suárez‐Calvet, Marc, Sacher, Christian, Blume, Tanja, Morenas‐Rodriguez, Estrella, Deming, Yuetiva, Piccio, Laura, Cruchaga, Carlos, Kleinberger, Gernot, Shaw, Leslie, Trojanowski, John Q, Herms, Jochen, Dichgans, Martin, Brendel, Matthias, Haass, Christian, Franzmeier, Nicolai
Publicado 2020

Plasma phosphorylated tau181 predicts cognitive and functional decline

por Tropea, Thomas F., Waligorska, Teresa, Xie, Sharon X., Nasrallah, Ilya M., Cousins, Katheryn A. Q., Trojanowski, John Q., Grossman, Murray, Irwin, David J., Weintraub, Daniel, Lee, Edward B., Wolk, David A., Chen‐Plotkin, Alice S., Shaw, Leslie M.
Publicado 2022

The expendables: Bioarchaeological evidence for pauper apprentices in 19(th) century England and the health consequences of child labour

por Gowland, Rebecca L., Caffell, Anwen C., Quade, Leslie, Levene, Alysa, Millard, Andrew R., Holst, Malin, Yapp, Poppy, Delaney, S., Brown, Chloe, Nowell, Geoff, McPherson, Colin, Shaw, Heidi A., Stewart, Nicolas A., Robinson, Sally, Montgomery, Janet, Alexander, Michelle M.
Publicado 2023

Derivation of cutoffs for the Elecsys(®) amyloid β (1–42) assay in Alzheimer's disease

por Shaw, Leslie M., Waligorska, Teresa, Fields, Leona, Korecka, Magdalena, Figurski, Michal, Trojanowski, John Q., Eichenlaub, Udo, Wahl, Simone, Quan, Marian, Pontecorvo, Michael J., Lachno, D. Richard, Talbot, Jayne A., Andersen, Scott W., Siemers, Eric R., Dean, Robert A.
Publicado 2018

Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer’s disease

por Nho, Kwangsik, Horgusluoglu, Emrin, Kim, Sungeun, Risacher, Shannon L., Kim, Dokyoon, Foroud, Tatiana, Aisen, Paul S., Petersen, Ronald C., Jack, Clifford R., Shaw, Leslie M., Trojanowski, John Q., Weiner, Michael W., Green, Robert C., Toga, Arthur W., Saykin, Andrew J.
Publicado 2016

Plasma tau in Alzheimer disease

por Mattsson, Niklas, Zetterberg, Henrik, Janelidze, Shorena, Insel, Philip S., Andreasson, Ulf, Stomrud, Erik, Palmqvist, Sebastian, Baker, David, Tan Hehir, Cristina A., Jeromin, Andreas, Hanlon, David, Song, Linan, Shaw, Leslie M., Trojanowski, John Q., Weiner, Michael W., Hansson, Oskar, Blennow, Kaj
Publicado 2016

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer’s disease

por Jack, Clifford R., Wiste, Heather J., Vemuri, Prashanthi, Weigand, Stephen D., Senjem, Matthew L., Zeng, Guang, Bernstein, Matt A., Gunter, Jeffrey L., Pankratz, Vernon S., Aisen, Paul S., Weiner, Michael W., Petersen, Ronald C., Shaw, Leslie M., Trojanowski, John Q., Knopman, David S.
Publicado 2010

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)

por Risacher, Shannon L., Kim, Sungeun, Shen, Li, Nho, Kwangsik, Foroud, Tatiana, Green, Robert C., Petersen, Ronald C., Jack, Clifford R., Aisen, Paul S., Koeppe, Robert A., Jagust, William J., Shaw, Leslie M., Trojanowski, John Q., Weiner, Michael W., Saykin, Andrew J.
Publicado 2013

Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

por Timmers, Maarten, Van Broeck, Bianca, Ramael, Steven, Slemmon, John, De Waepenaert, Katja, Russu, Alberto, Bogert, Jennifer, Stieltjes, Hans, Shaw, Leslie M., Engelborghs, Sebastiaan, Moechars, Dieder, Mercken, Marc, Liu, Enchi, Sinha, Vikash, Kemp, John, Van Nueten, Luc, Tritsmans, Luc, Streffer, Johannes Rolf
Publicado 2016

Detection of β-amyloid positivity in Alzheimer’s Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers

por Tosun, Duygu, Veitch, Dallas, Aisen, Paul, Jack, Clifford R, Jagust, William J, Petersen, Ronald C, Saykin, Andrew J, Bollinger, James, Ovod, Vitaliy, Mawuenyega, Kwasi G, Bateman, Randall J, Shaw, Leslie M, Trojanowski, John Q, Blennow, Kaj, Zetterberg, Henrik, Weiner, Michael W
Publicado 2021

Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease

por Libiger, Ondrej, Shaw, Leslie M., Watson, Mark H., Nairn, Angus C., Umaña, Kelly L., Biarnes, Michael C., Canet‐Avilés, Rosa M., Jack, Clifford R., Breton, Yannick‐André, Cortes, Laetitia, Chelsky, Daniel, Spellman, Daniel S., Baker, Susan A., Raghavan, Nandini, Potter, William Z.
Publicado 2021

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

por Toledo, Jon B, Cairns, Nigel J, Da, Xiao, Chen, Kewei, Carter, Deborah, Fleisher, Adam, Householder, Erin, Ayutyanont, Napatkamon, Roontiva, Auttawut, Bauer, Robert J, Eisen, Paul, Shaw, Leslie M, Davatzikos, Christos, Weiner, Michael W, Reiman, Eric M, Morris, John C, Trojanowski, John Q
Publicado 2013

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease

por Nho, Kwangsik, Kim, Sungeun, Horgusluoglu, Emrin, Risacher, Shannon L., Shen, Li, Kim, Dokyoon, Lee, Seunggeun, Foroud, Tatiana, Shaw, Leslie M., Trojanowski, John Q., Aisen, Paul S., Petersen, Ronald C., Jack, Clifford R., Weiner, Michael W., Green, Robert C., Toga, Arthur W., Saykin, Andrew J.
Publicado 2017

Selenium detoxification is required for cancer cell survival

por Carlisle, Anne E., Lee, Namgyu, Matthew-Onabanjo, Asia N., Spears, Meghan E., Park, Sung Jin, Youkana, Daniel, Doshi, Mihir B., Peppers, Austin, Li, Rui, Joseph, Alexander B., Smith, Miles, Simin, Karl, Zhu, Lihua Julie, Greer, Paul L., Shaw, Leslie M., Kim, Dohoon
Publicado 2020