“…Denosumab has been used successfully to treat disease‐associated osteoclast overactivity, including giant cell tumor of bone. Given its mechanism of action, denosumab is a potent potential treatment of other osteoclast bone dysplasias including central giant cell granuloma (CGCG), aneurysmal bone cyst (ABC), and cherubism. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SIMPLE SUMMARY: Anesthesia is often required for the medical management of large tortoise species, but little has been published regarding effective anesthetic regimens for these species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sodium channel inactivation of squid giant axons can be completely removed by CT at neutral pH. …”
Enlace del recurso
Enlace del recurso

“…The histopathology of granuloma tissue showed significant inhibition of lymphocytes, neutrophils, exudates, necrosis and giant cell when compared with control without ulcerogenic effect. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ancient DNA and microscopic analyses of 84 coprolites deposited by four moa species (South Island giant moa, Dinornis robustus; little bush moa, Anomalopteryx didiformis; heavy-footed moa, Pachyornis elephantopus; and upland moa, Megalapteryx didinus) reveal an array of gastrointestinal parasites including coccidians (Cryptosporidium and members of the suborder Eimeriorina), nematodes (Heterakoidea, Trichostrongylidae, Trichinellidae) and a trematode (Echinostomida). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Background: Pancreatic adenocarcinoma remains one of the most lethal malignancies with little treatment advancements. Other less common pancreatic cancer histologies have different outcomes and disease course. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the past, viruses were considered nonliving infectious particles, little more than genetic material wrapped in a protein capsid. …”
Enlace del recurso
Enlace del recurso

“…We present a case of sciatica diagnosed with giant gluteal lipoma presenting as sciatic notch hernia and compressing sciatic nerve in the greater sciatic notch. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sfrp1 and Sfrp5 double knockout mice exhibited disturbed trophoblast differentiation in the placental ectoplacental cone (EPC), which contains the precursors of trophoblast giant cells (TGCs) and spongiotrophoblast cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most common histological type of benign tumors was a giant cell tumor accounting for 14.8% (205 cases) of all tumors, followed by neurofibroma, schwannoma, and other types. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although a number of cellular components of cytokinesis have been identified, little is known about the detailed mechanisms underlying this process. …”
Enlace del recurso
Enlace del recurso

“…We have examined the effects of a variety of monovalent cations on K channel gating in squid giant axons. The addition of the permeant cations K, Rb, or Cs to the external medium decreases the channel closing rate and causes a negative shift of the conductance-voltage relationship. …”
Enlace del recurso
Enlace del recurso

“…Photodynamic alteration of lobster giant axons drastically changed the magnitude and kinetics of sodium currents seen under voltage clamp using the sucrose gap technique. …”
Enlace del recurso
Enlace del recurso

“…In single muscle fibers from the giant barnacle, a small decrease in muscle length decreases both the calcium activation and the peak isometric tension produced by a constant current stimulus. …”
Enlace del recurso
Enlace del recurso

“…Children more often develop giant aneurysms, and may become symptomatic from the mass effect of the aneurysm (tumorlike symptoms). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This means that there is going to be a run-off election between the two giant political parties: the ruling NDC and the major opposition party, NPP. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In Lethocerus, a giant water bug often used as a model system because of its large muscle fibers, there are two troponin-C isoforms, called F1 and F2, that have distinct roles in activating the muscle. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Little attention has been paid to the toxicity of silver amalgam fillings, which have been used over the centuries in Dentistry. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In humans, retinoic acid receptor responders (RARRES) have been shown to be altered in third trimester placentas complicated by the pathologies preeclampsia (PE) and PE with intrauterine growth restriction (IUGR). Currently, little is known about the role of placental Rarres in rodents. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, little is known about how these proteins function in neurons. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso