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  1. 111421
    “…This compound (9) inhibited both cathepsin L and 3CL protease at low nanomolar concentrations, and also exerted anti-CoV-2 activity in an infected human cell line.…”
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    Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents
  2. 111422
    “…METHODS: Thirty young male athletes (24 ± 4 years) regularly practicing resistance training were enrolled in this three-arm, placebo(PL)-controlled crossover trial with ingestion of two commercially available supplements: an amino acid combination (AA) (containing 3 g of L-arginine-hydrochloride and 8 g of L-citrulline-malate) and 300 mg of a specific green tea extract (GTE). …”
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    New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomized, double-blind, placebo-controlled crossover trial in healthy young athletes using contrast-enhanced ultrasound (CEUS)
  3. 111423
    “…The pathways enriched by the differential metabolites in the M and T groups were intersected, and a total of 5 common pathways were obtained (amino acid tRNA biosynthesis, D-glutamine and D-glutamate metabolism, tryptophan metabolism, nitrogen metabolism, and arginine and proline metabolism). …”
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    Deciphering the Metabolomics-Based Intervention of Yanghe Decoction on Hashimoto's Thyroiditis
  4. 111424
    “…In Argentina, the human T-cell lymphotropic virus type 1 (HTLV-1) infection has been documented mainly among blood banks with a prevalence of ~0.02–0.046% for Buenos Aires city, 0.8% for the northeast, and 1% for the northwest; both areas are considered endemic for HTLV-2 and 1, respectively. …”
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    Making Visible HTLV Infection in a Non-endemic Area of Argentina
  5. 111425
    “…These results imply that Spats1 is a male-specific expressed gene that is mainly regulated by MT and is closely linked to spermatogenesis and release in P. sinensis.…”
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    Expression and Characterization of the Spats1 Gene and Its Response to E2/MT Treatment in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)
  6. 111426
    “…GO and KEGG analysis showed that the target genes of DEGs and differentially expressed lncRNAs (DE-lncRNAs) were mainly associated with amino acid metabolism, fatty acid metabolism, channel activity, and other processes. …”
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    The Association of lncRNA and mRNA Changes in Adipose Tissue with Improved Insulin Resistance in Type 2 Obese Diabetes Mellitus Rats after Roux-en-Y Gastric Bypass
  7. 111427
    “…Moreover, we identified 53 kinds of metabolic functions that were mainly involved in sugar, lipid, and amino acid metabolism. CONCLUSIONS: Our results indicated that low dynamics of gut microbiota composition and high dynamics of its metabolic function from T2 to T3 were associated with TPOAb(+) SCH. …”
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    Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study
  8. 111428
    “…Most differential metabolites were significantly enriched in amino acid, fatty acid metabolism, digestive system secretion and ovarian steroidogenesis pathways. …”
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    Correlation analysis of serum reproductive hormones and metabolites during multiple ovulation in sheep
  9. 111429
    “…The DEGs of T12 were mainly involved in plant–pathogen interaction, cysteine and methionine metabolism, phagosomes, biosynthesis of amino acids, phenylalanine, tyrosine and tryptophan biosynthesis, plant hormone signal transduction, and starch and sucrose metabolism pathways. …”
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    Physiological and Transcriptome Analysis on Diploid and Polyploid Populus ussuriensis Kom. under Salt Stress
  10. 111430
    “…The docking results regarding the interaction of CBZ and voltage-gate Na(+) (Na(V)) channel predicted the ability of CBZ to bind to some amino-acid residues in Na(V) due to the existence of a hydrogen bond or hydrophobic contact. …”
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    Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na(+) and Erg-Mediated K(+) Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line
  11. 111431
    “…Also, a total of 75,517 mutations in the amino acid were identified (averaging 20.2 mutations per sample). …”
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    Analysis of the mutation dynamics of SARS-CoV-2 genome in the samples from Georgia State of the United States
  12. 111432
    “…Serum concentrations of procollagen type-1 amino-terminal propeptide (PINP), parathyroid hormone PTH, estrogen (ES), and osteocalcin (OC) were determined with enzyme-linked immunosorbent assay (ELISA). …”
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    Effects of Calcium Lactate-Enriched Pumpkin on Calcium Status in Ovariectomized Rats
  13. 111433
    “…These positive responses owed to increase the osmolytes level (proline, free amino acids, and soluble sugars) and antioxidative compounds (non-enzymatic concentration, enzymatic activities, phenolic acid, and carotenoids). …”
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    Coapplication of Effective Microorganisms and Nanomagnesium Boosts the Agronomic, Physio-Biochemical, Osmolytes, and Antioxidants Defenses Against Salt Stress in Ipomoea batatas
  14. 111434
    “…Despite similar organizations and predicted topologies, truncated mutants of the HolB and HolV proteins showed different toxicity levels, suggesting that differences in amino acid composition influence their lysis properties. …”
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    Getting Outside the Cell: Versatile Holin Strategies Used by Distinct Phages to Leave Their Bacillus thuringiensis Host
  15. 111435
    “…During viral evolution, non-synonymous mutations have fixed along the viral genome, leading to amino acid (aa) changes that can be variant-specific (V-markers). …”
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    Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins
  16. 111436
    “…Transition to HFD led to increases in the relative abundance of KEGG orthology (KO) terms related to starch and sucrose metabolism, fatty acid biosynthesis, and amino sugar and nucleotide sugar metabolism, while transition to CD resulted in increased relative abundance of KO terms pertaining to inositol phosphate metabolism and sulfur metabolism. …”
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    Longitudinal fecal microbiome and metabolite data demonstrate rapid shifts and subsequent stabilization after an abrupt dietary change in healthy adult dogs
  17. 111437
    “…Finally, it suggested species interactions to be based on formate and amino acids exchanges. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40168-022-01311-1.…”
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    Integrating metagenomic binning with flux balance analysis to unravel syntrophies in anaerobic CO(2) methanation
  18. 111438
    “…In the encoding layer, we treat each amino acid as a word, and map it into an N-dimensional vector. …”
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    DCSE:Double-Channel-Siamese-Ensemble model for protein protein interaction prediction
  19. 111439
    “…It is also unknown whether such changes are altered in different pathologies or linked to the degree of reperfusion injury and inflammatory response. …”
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    Pathology-related changes in cardiac energy metabolites, inflammatory response and reperfusion injury following cardioplegic arrest in patients undergoing open-heart surgery
  20. 111440
    “…The only respiratory quinone was menaquinone-6 (MK-6). The major cellular fatty acids were iso-C(15:0), iso-C(15:1)G, and iso-C(17:0) 3-OH. …”
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    Hanstruepera marina sp. nov. and Hanstruepera flava sp. nov., two novel species in the family Flavobacteriaceae isolated by a modified in situ cultivation technique from marine sediment
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