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  1. 111921
    “…RESULTS: Two hundred and eighty one non-identical amino acid sequences were identified (< 95% sequence identity). …”
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    Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria
  2. 111922
    “…CONCLUSION/SIGNIFICANCE: Together, these data indicate that Phe223 and Ser225 are required for the M-line localization of Smyd1b_tv1.…”
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    Smyd1b_tv1, a Key Regulator of Sarcomere Assembly, Is Localized on the M-Line of Skeletal Muscle Fibers
  3. 111923
    “…BACKGROUND: The SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain is an evolutionarily conserved sequence of approximately 130-150 amino acids, and constitutes the catalytic site of lysine methyltransferases (KMTs). …”
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    Phylogenetic analysis and classification of the Brassica rapa SET-domain protein family
  4. 111924
    “…Sequence analyses indicated that these receptors are orthologous to arthropod D(1)-like (Gα(s)-coupled) receptors, but share less than 55% amino acid identity in conserved domains with mammalian dopamine receptors. …”
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    A “Genome-to-Lead” Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes aegypti D(1)-like Dopamine Receptors
  5. 111925
    “…The FFR models of InhA explicitly characterizes the overall movements of the amino acid residues in helices, strands, loops, and turns, allowing the ligand to properly accommodate itself in the receptor’s binding site. …”
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    Effect of the explicit flexibility of the InhA enzyme from Mycobacterium tuberculosis in molecular docking simulations
  6. 111926
    “…A concomitant reduction in transcripts was observed with ribosome and terpenoid backbone biosynthesis, TCA cycle, amino acid metabolism and RNA degradation. Analysis of changes in transcription factor mRNA abundance shows that hypoxia induces significant positive and negative changes that may be important for regulating the hypoxia response in this pathogenic mold. …”
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    Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
  7. 111927
    “…We conclude by presenting a plateau mode assay, where we use a non-focusing tracer (NFT) species to visualize the separation and perform quantitation of amino acids.…”
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    On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
  8. 111928
    “…Aβ 1-42, tTau, and pTau (at amino acid 181) were measured in CSF by ELISA technique. …”
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    Alzheimer's Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers: Difference in Cut-Off Levels from Thai Experience
  9. 111929
    por Lewis, Patrick A.
    Publicado 2012
    “…Leucine Rich Repeat Kinase 2 (LRRK2) is a 2527 amino acid member of the ROCO family of proteins, possessing a complex, multidomain structure including a GTPase domain (termed ROC, for Ras of Complex proteins) and a kinase domain(1). …”
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    Assaying the Kinase Activity of LRRK2 in vitro
  10. 111930
    “…Of the polymorphisms, 147 occurred in coding regions and only 30 resulted in amino acid changes in 7 of the RSV genes. CONCLUSIONS: These data suggest that RSV strains may not be homogeneous with regard to pathogenesis or virulence. …”
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    Induction of IL-6 and CCL5 (RANTES) in human respiratory epithelial (A549) cells by clinical isolates of respiratory syncytial virus is strain specific
  11. 111931
    “…HTLV-1 and HTLV-2 encode accessory proteins p30 and p28, respectively, which share partial amino acid homology and are required for viral persistence in vivo. …”
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    Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses
  12. 111932
    “…METHODS: Derivatisation of a stabilised DOTA-BN(7–14)[Cha(13),Nle(14)] analogue with a linear PEG molecule of 5 kDa (PEG(5k)) was performed by PEGylation of the ϵ-amino group of a β(3)hLys-βAla-βAla spacer between the BN sequence and the DOTA chelator. …”
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    PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with (177)Lu-DOTA-bombesin analogues
  13. 111933
    “…Urine organic acid and plasma amino acids profiles were analyzed. PCR-sequencing of all 18 exons of SLC25A13 and gap PCR for the mutations IVS16ins3kb and Ex16+74_IVS17-32del516 were performed. mRNA were analyzed in selected cases with possible splicing error. …”
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    Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13 mutations among thai infants
  14. 111934
    “…This approach, termed QUICK for QUantitative Immunoprecipitation Combined with Knockdown(4), employs Stable Isotope Labeling of Amino acids in Cell culture (SILAC)(5) and MS to quantify the amounts of proteins immunoprecipitated from wild-type and knock-down strains. …”
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    A Protocol for the Identification of Protein-protein Interactions Based on (15)N Metabolic Labeling, Immunoprecipitation, Quantitative Mass Spectrometry and Affinity Modulation
  15. 111935
    “…In glycosylation site prediction, the rules produced were also interpretable and the most popular rules generated appeared to correlate well with recently reported hydrophilic/hydrophobic enhancement values of amino acids around possible O-glycosylation sites. …”
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    Logic minimization and rule extraction for identification of functional sites in molecular sequences
  16. 111936
    “…BACKGROUND AND METHODS: It has been reported that C/T dimorphism at position 1418 of the thrombomodulin gene causes a cytosine (C) transition to thymidine (T), resulting in an alanine (A) to valine (V) substitution at amino acid position 455 (TM455). TM455 had been found not only in African American and American whites, but also in whites in The Netherlands and Sweden. …”
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    Association of thrombomodulin Ala455Val dimorphism and inflammatory cytokines with carotid atherosclerosis in the Chinese Han population
  17. 111937
    “…BACKGROUND: Recombinant C1 inhibitor (rhC1INH) is a novel therapeutic option for the treatment of acute angioedema attacks in patients with hereditary angioedema (HAE). The amino acid sequence of rhC1INH is identical to that of endogenous C1INH. …”
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    84 Immuno-Safety of Recombinant Human C1 Inhibitor in Patients With Hereditary Angioedema: An Integrated Analysis
  18. 111938
    “…NP oligomerization along the viral RNA is mediated largely by a 28-amino-acid tail loop. Influenza viral RNPs, which serve as the templates for viral RNA synthesis in the nuclei of infected cells, are not linear but rather are organized in hairpin-like double-helical structures. …”
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    Biochemical and Structural Evidence in Support of a Coherent Model for the Formation of the Double-Helical Influenza A Virus Ribonucleoprotein
  19. 111939
    “…We investigated the role of the endogenous N/OFQ receptor (NOP) system using the nonpeptidic NOP antagonist, JTC-801 [N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxy-methyl)benzamide monohydrochloride], during the HPA axis response to acute physical/psychological stress (60 min of restraint). …”
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    Role of Nociceptin/Orphanin FQ and NOP Receptors in the Response to Acute and Repeated Restraint Stress in Rats
  20. 111940
    “…BACKGROUND: Foot-and-mouth disease virus (FMDV) initiates infection via recognition of one of at least four cell-surface integrin molecules α(v)β(1), α(v)β(3), α(v)β(6), or α(v)β(8) by a highly conserved Arg-Gly-Asp (RGD) amino acid sequence motif located in the G-H loop of VP1. …”
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    Examination of soluble integrin resistant mutants of foot-and-mouth disease virus
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