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112321“…The sequence that would encode valine (V) at position 293 of SCD was linked to 3 [Formula: see text]-UTR variant [Formula: see text] , and the sequence that would encode alanine (A) was linked to variants [Formula: see text] and [Formula: see text]. …”
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112322“…Both recognize the same consensus DNA binding motif via their C-terminal zinc finger domains and regulate the expression of their target genes by recruiting chromatin modifiers such as histone deacetylases (HDACs) and demethylases (LSD1) by using an N-terminal SNAG domain that comprises only 20 amino acids. The only region that is different between both proteins is the region that separates the zinc finger domains and the SNAG domain. …”
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112323por Kebir, Sied, Schmidt, Teresa, Weber, Matthias, Lazaridis, Lazaros, Galldiks, Norbert, Langen, Karl-Josef, Kleinschnitz, Christoph, Hattingen, Elke, Herrlinger, Ulrich, Lohmann, Philipp, Glas, Martin“…Although pseudoprogression has only a moderate prevalence of 10–30% following first-line treatment of glioblastoma patients, it bears critical implications for affected patients. …”
Publicado 2020
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112324“…Moreover, the effects of dietary amino acid (AA) on the production performance of weaning pigs could be mediated through milk composition change.…”
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112325por Zaworska-Zakrzewska, Anita, Kasprowicz-Potocka, Małgorzata, Twarużek, Magdalena, Kosicki, Robert, Grajewski, Jan, Wiśniewska, Zuzanna, Rutkowski, Andrzej“…This work comprised extensive analyses, both chemical (the composition of amino acids and anti-nutritional factors) and microbiological, also including mycotoxins. …”
Publicado 2020
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112326por Dabouz, Rabah, Cheng, Colin W. H., Abram, Pénélope, Omri, Samy, Cagnone, Gael, Sawmy, Khushnouma Virah, Joyal, Jean-Sébastien, Desjarlais, Michel, Olson, David, Weil, Alexander G., Lubell, William, Rivera, José Carlos, Chemtob, Sylvain“…Here, we identify specific cell types that generate IL-1β and harbor the IL-1 receptor (IL-1R) and pharmacologically validate IL-1β’s contribution to neuro-retinal degeneration using the IL-1R allosteric modulator composed of the amino acid sequence rytvela (as well as the orthosteric antagonist, Kineret) in a model of blue light–induced retinal degeneration. …”
Publicado 2020
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112327por Zaworska-Zakrzewska, Anita, Kasprowicz-Potocka, Małgorzata, Mikuła, Robert, Taciak, Marcin, Pruszyńska-Oszmałek, Ewa, Frankiewicz, Andrzej“…It increased contents of crude protein, crude fiber and ash, but reduced nitrogen-free extractive levels. The amino acid profile of fermented lupine (FL) was similar to that of raw lupine (RL) seeds, whereas the contents of oligosaccharides and P-phytate decreased significantly, in contrast to alkaloids. …”
Publicado 2020
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112328“…Besides the loop regions, surprisingly, mainly the RNA-binding motif RNP1 is involved in ssDNA and RNA binding, while only two amino acids, H28 and W29, of the postulated RNA-binding motif RNP2 interact with the uridylate and thymidylate homonucleotides, although a high affinity in the nanomolar range is achieved. …”
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112329por Clausen, Henning, Norén, Elisabeth, Valtonen, Salla, Koivu, Aki, Sairanen, Mikko, Liuba, Petru“…OBJECTIVES: To assess the performance of a dried blood spot (DBS) test to measure the cardiovascular biomarker amino terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) levels in newborns and to compare DBS with standard EDTA analysis in control newborns during the first week of life. …”
Publicado 2020
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112330por Wilde, Blake R., Kaadige, Mohan R., Guillen, Katrin P., Butterfield, Andrew, Welm, Bryan E., Ayer, Donald E.“…BACKGROUND: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. …”
Publicado 2020
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112331por Sun, Wei-Wei, Yan, Xiu-Mei, Shi, Qing, Zhang, Yuan-Jiao, Huang, Jun-Ting, Huang, Hui-Cong, Shi, Hong-Fei, Yan, Bao-Long“…RESULTS: Our results showed that Acan-RPS-30 consisted of 130 amino acids. It was grouped into clade V with C. elegans in the phylogenetic analysis. …”
Publicado 2020
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112332“…The two major exoU clones differed substantially in the composition and flexibility of the accessory genome and by more than 8,000 amino acid sequences. Pronounced sequence variation between orthologs was noted in genes encoding elements of secretion systems and secreted effector molecules, including the type III secretion system, indicating the modes of action of the different clones. …”
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112333por Siah, A, Breyta, R B, Warheit, K I, Gagne, N, Purcell, M K, Morrison, D, Powell, J F F, Johnson, S C“…The additional full-genome sequences herein strengthen our understanding of phylogeographical patterns related to the northeast Pacific, but a more balanced representation of full PRV-1 genomes from across its range, as well additional sequencing of archived samples, is still needed to better understand global relationships including potential transmission links among regions.…”
Publicado 2020
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112334“…Codon usage, RNA editing sites, and repeat analyses also revealed highly similar results for the six cp genomes. The amino acid leucine has the highest proportion and almost all favored synonymous codons have either an A or U ending. …”
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112335por Zhang, Fanfan, Yuan, Weifeng, Li, Zhiquan, Zhang, Yuhan, Zeng, Xiuxiu, Zhao, Min, Ye, Yu, Ding, Zhen, He, Houjun, Wu, Qiong, Song, Deping, Tang, Yuxin“…Multialignment analysis indicated that JX/CH/2018 had 97.7–99.7% nucleotide identity at the complete genome level, and 97.2–100% at the amino acid level of the capsid protein when compared with reference PCV3 strains. …”
Publicado 2020
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112336por Álvaro-Alonso, César, Ferrer-Donato, Águeda, Fernández-Torres, Elizabeth, Carballo-Villa, Mónica, Fernandez-Martos, Carmen M.“…We studied the reproductive parameters of mice hemizygous for TDP-43(A315T) transgene, which are viable, fertile, and express a mutant human TAR DNA binding protein (hTDP-43) cDNA harboring an amino acid substitution associated with familial amyotrophic lateral sclerosis (fALS). …”
Publicado 2020
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112337“…SIMPLE SUMMARY: Canola co-products, which are included in swine diets as a source of amino acids, contain glucosinolates that limit the inclusion of these co-products in swine diets. …”
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112338por Mojica, Maria F, Rutter, Joseph, Taracila, Magdalena A, Papp-Wallce, Krisztina M, Spencer, James, Vila, Alejandro J, Bonomo, Robert A“…Recently, we described novel variants of the L1 and L2 in a collection of clinical S. maltophilia isolates collected in the US, and showed through analyses of the amino acid sequences that L1 and L2 grouped into 4 (A-D, B, C, and E) and 2 (A and D) clades, respectively. …”
Publicado 2020
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112339por Danaher, Patrick, Phillips, Michael, Schmitt, Peter, Richard, Stephanie, Millar, Gene, White, Brian, Okulicz, Jason, Coles, Christian L, Burgess, Timothy“…Based on their mass spectra, these biomarker VOCs were tentatively identified as 2-amino-1-propanol, 2-butanamine, n-nitro, 3-methyl-hexanal, and heptane, which are consistent with products of oxidative stress. …”
Publicado 2020
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112340por Tabor, David E, Tkaczyk, Christine, Tovchigrechko, Andrey, Sellman, Bret R, McCarthy, Michael, Ren, Pin, Shoemaker, Kathryn, Jafri, Hasan S, François, Bruno, Esser, Mark T, Coppens, Jasmine, Timbermont, Leen, Xavier, Basil, Lammens, Christine, Goossens, Herman, Malhotra-Kumar, Surbhi, Ruzin, Alexey“…AT gene (hla) sequences were translated and amino acid variation was identified in comparison to the reference SA USA300 FPR3757. …”
Publicado 2020
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