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112441“…Plant extracts are at times associated with vitamins (A,D,E,C, folic acid), minerals (Zn, Se, Fe, Mg) and amino acids (arginine aspartate, L-carnitine). For fertility/climacterium associated symptoms, DHA, EPA, lycopene and CoQ10 are also found. …”
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112442por Guida, Florence, Tan, Vanessa Y., Corbin, Laura J., Smith-Byrne, Karl, Alcala, Karine, Langenberg, Claudia, Stewart, Isobel D., Butterworth, Adam S., Surendran, Praveen, Achaintre, David, Adamski, Jerzy, Amiano, Pilar, Bergmann, Manuela M., Bull, Caroline J., Dahm, Christina C., Gicquiau, Audrey, Giles, Graham G., Gunter, Marc J., Haller, Toomas, Langhammer, Arnulf, Larose, Tricia L., Ljungberg, Börje, Metspalu, Andres, Milne, Roger L., Muller, David C., Nøst, Therese H., Pettersen Sørgjerd, Elin, Prehn, Cornelia, Riboli, Elio, Rinaldi, Sabina, Rothwell, Joseph A., Scalbert, Augustin, Schmidt, Julie A., Severi, Gianluca, Sieri, Sabina, Vermeulen, Roel, Vincent, Emma E., Waldenberger, Melanie, Timpson, Nicholas J., Johansson, Mattias“…The PC with the strongest association was PC ae C34:3 with an odds ratio (OR) for 1 standard deviation (SD) increment of 0.75 (95% confidence interval [CI]: 0.68 to 0.83, p = 2.6 × 10(−8)). In contrast, 4 amino acids, including glutamate (OR for 1 SD = 1.39, 95% CI: 1.20 to 1.60, p = 1.6 × 10(−5)), were positively associated with risk. …”
Publicado 2021
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112443por Patson, Noel, Mukaka, Mavuto, D’Alessandro, Umberto, Chapotera, Gertrude, Mwapasa, Victor, Mathanga, Don, Kazembe, Lawrence, Laufer, Miriam K., Chirwa, Tobias“…Using joint modelling, we investigated whether clinical AEs vary by treatment and how laboratory outcomes (alanine amino-transferase, total bilirubin) and concomitant medication are associated with clinical AEs over time following artemisinin-based antimalarial therapy. …”
Publicado 2021
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112444por Elfers, Clinton T., Blevins, James E., Lawson, Elizabeth A., Pittner, Richard, Silva, David, Kiselyov, Alex, Roth, Christian L.“…Methods: ASK1476 features two specific amino acid substitutions in positions 7 and 8 combined with a short polyethylene glycol spacer. …”
Publicado 2021
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112445por Qi, Yue A., Maity, Tapan K., Gao, Shaojian, Gong, Tao, Bahta, Meriam, Venugopalan, Abhilash, Zhang, Xu, Guha, Udayan“…This large-scale dataset revealed that the Class I-presented immunopeptidome was suppressed in two third-generation EGFR TKI, osimertinib-resistant lung adenocarcinoma cell lines compared to their isogenic TKI-sensitive counterparts. …”
Publicado 2021
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112446por Hardy, Julie, Bonin, Patricia, Lazuka, Adele, Gonidec, Estelle, Guasco, Sophie, Valette, Corinne, Lacroix, Sébastien, Cabrol, Léa“…During anaerobic digestion (AD) of protein-rich wastewater, ammonium (NH(4)(+)) is released by amino acid degradation. High NH(4)(+) concentrations disturb the AD microbiome balance, leading to process impairments. …”
Publicado 2021
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112447por Beach, Natalie K., Myers, Kevin S., Owen, Brian R., Seib, Matt, Donohue, Timothy J., Noguera, Daniel R.“…Using phylogenetic analyses, evaluation of sequence conservation in important amino acid residues, and prediction of genes regulated by TFs in the MAGs, we identified homologs of the oxygen-sensing FNR in Nitrosomonas and Rhodocyclaceae, nitrogen-sensing dissimilative nitrate respiration regulator that responds to nitrogen species (DNR) in Rhodocyclaceae, and nitrogen-sensing nitrite and nitric oxide reductase regulator that responds to nitrogen species (NnrR) in Nitrospira MAGs. …”
Publicado 2021
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112448por Zhu, Jie, Qi, Mingpu, Jiang, Chuanwen, Peng, Yongchong, Peng, Qingjie, Chen, Yingyu, Hu, Changmin, Chen, Jianguo, Chen, Xi, Chen, Huanchun, Guo, Aizhen“…Sequence alignment against known astrovirus (AstV) strains at the levels of both amino acids and nucleotides showed a high genetic diversity. …”
Publicado 2021
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112449por Peel, Jennifer S., McNarry, Melitta A., Heffernan, Shane M., Nevola, Venturino R., Kilduff, Liam P., Waldron, Mark“…CONCLUSION: Supplements such as caffeine and nitrates do not enhance endurance performance in the heat, with caffeine also increasing core temperature responses. Some amino acids might offer the greatest performance benefits in the heat. …”
Publicado 2021
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112450por Ren, Huiling, Yin, Xin, Su, Chao, Guo, Miaomiao, Wang, Xue-Feng, Na, Lei, Lin, Yuezhi, Wang, Xiaojun“…Abbreviations:3-MA: 3-methyladenine; AA: amino acid; ACTB: actin beta; AD: activation domain; ATG: autophagy related; Baf A1: bafilomycin A(1); BD: binding domain; BECN1: beclin 1; BH3: BCL2-homology-3 domain; BiFC: bimolecular fluorescence complementation; CCD: coiled-coil domain; class III PtdIns3K: class III phosphatidylinositol 3-kinase; CQ: chloroquine; Co-IP: co-immunoprecipitation; dNTPase: dGTP-stimulated deoxynucleoside triphosphate triphosphohydrolase; ECD: evolutionarily conserved domain; EIAV: equine infectious anemia virus; eMDMs: equine monocyte-derived macrophages; GFP: green fluorescent protein; HD: histidine-aspartic; HIV-1: human immunodeficiency virus-1; hpi: hours post infection; hpt: hours post transfection; KO: knockout; LAMP2: lysosomal associated membrane protein 2; LMB: leptomycin B; PMA: phorbol 12-myristate 13-acetate; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; ND: unknown non-essential domain; NES: nuclear export signal; NLS: localization signal; NS: statistically non-significant; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; RBD: RNA binding domain; RT: reverse transcriptase; siRNAs: small interfering RNAs; SAMHD1: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1; SIV: simian immunodeficiency virus; VN: C-terminal residues of Venus 174 to 238; VC: N-terminal residues 2 to 173 of Venus…”
Publicado 2020
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112451por Yang, Jinping, Li, Shasha, Feng, Tao, Zhang, Xiangle, Yang, Fan, Cao, Weijun, Chen, Hongjun, Liu, Huisheng, Zhang, Keshan, Zhu, Zixiang, Zheng, Haixue“…Truncation mutation analysis indicated that the region spanning amino acids 109 to 208 of F317L was critical for inhibition of NF-κB activity. …”
Publicado 2021
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112452“…METHODS: Based on the amino acid sequences of the gene products of both CLCuKoV-Bu and ToLCNDV, protein structures were generated using different software, i.e., MODELLER, I-TASSER, QUARKS, LOMETS and RAPTORX. …”
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112453“…Among these AMPs, thrombin-derived C-terminal peptide (TCP) was the dominant type, followed by RegIIIgamma and chemokine. The amino acid sequences of the TCP, cgUbiquitin, RegIIIalpha, RegIIIgamma, chemokine shared 32.55%, 42.63%, 29.87%, 28.09%, and 32.15% similarities among the same type in S. schlegelii. …”
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112454“…The function of Malpighian tubules was damaged, the contents of glucose, trehalose, lipid, total soluble amino acids and protein were lowered and the fat bodies were lessened in the HvvATPaseG RNAi larvae, compared with those in the PBS- and dsegfp-fed beetles. …”
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112455“…The intra-clade average amino acid identity (AAI) and percentage of conserved proteins (POCP) range from 52 to 68% and 37 to 59%, respectively, which are interspersed on the intra-genera cutoff values; therefore, we reassess the taxonomy of genus Alkalihalobacillus. …”
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112456“…Whole-genome analysis of phage-resistant bacteria revealed the rapZ gene acquired a premature stop mutation at amino acid 227. Here, we report that the mutation in the rapZ gene confers resistance by inhibiting 93.5% phage adsorption. …”
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112457“…We report here that only a small cysteine-free protein (CFP) is indispensable for insect pathogenicity of Beauveria bassiana among 10 studied SSPs (99 to 274 amino acids [aa]), including seven hypothetical proteins containing 0 to 12 Cys residues. …”
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112458por Amador-García, Ahinara, Zapico, Inés, Borrajo, Ana, Malmström, Johan, Monteoliva, Lucía, Gil, Concha“…Treatment with AA resulted in a general decrease in the abundance of proteins involved in amino acid biosynthesis, protein folding, and rRNA processing. …”
Publicado 2021
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112459por Yen, Ju-Bei, Chen, Lee-Wen, Wei, Ling-Huei, Hung, Chien-Hui, Wang, Shie-Shan, Lin, Chun-Liang, Chang, Pey-Jium“…Deletion analysis revealed that the N-terminal 179-amino-acid (aa) region of NTPase encompasses two LD-targeting motifs (designated LTM-1 and LTM-2), two apoptosis-inducing motifs, and multiple regulatory regions. …”
Publicado 2021
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112460por Sun, Fengming, Wang, Xiuhua, Tan, Shun, Dan, Yunjie, Lu, Yanqiu, Zhang, Juan, Xu, Junli, Tan, Zhaoxia, Xiang, Xiaomei, Zhou, Yi, He, Weiwei, Wan, Xing, Zhang, Wei, Chen, Yaokai, Tan, Wenting, Deng, Guohong“…The mutant spectrums covered ∼85% amino acid variations of public genomes (GISAID; frequency ≥ 0.1) and likely provided an advantage mutation pool for the current/future epidemic variants. …”
Publicado 2021
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