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112481por Feil, Katharina, Adrion, Christine, Boesch, Sylvia, Doss, Sarah, Giordano, Ilaria, Hengel, Holger, Jacobi, Heike, Klockgether, Thomas, Klopstock, Thomas, Nachbauer, Wolfgang, Schöls, Ludger, Steiner, Katharina Marie, Stendel, Claudia, Timmann, Dagmar, Naumann, Ivonne, Mansmann, Ulrich, Strupp, Michael“…OBJECTIVE: To investigate the efficacy, safety, and tolerability of the modified essential amino acid acetyl-DL-leucine in treating patients who have cerebellar ataxia. …”
Publicado 2021
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112482“…We identified a novel type of suppressor mutation, an amino acid substitution in the β-subunit Kis1, which enabled Kis1 to bind to Snf1 in the absence of Snf4, thereby restoring Mig1 and Mig2 downregulation, SNF1-dependent gene expression, and growth on alternative carbon sources. …”
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112483por Ngcobo, Jabulani Nkululeko, Ramukhithi, Fhulufhelo Vincent, Nephawe, Khathutshelo Agree, Mpofu, Takalani Judas, Chokoe, Tlou Caswell, Nedambale, Tshimangadzo Lucky“…Furthermore, processing techniques used for processing by-products could complement alterations of the amino acid profile and reduce protein retrieval. …”
Publicado 2021
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112484por Delgado, Inês L. S., Tavares, Alexandra, Francisco, Samuel, Santos, Dulce, Coelho, João, Basto, Afonso P., Zúquete, Sara, Müller, Joachim, Hemphill, Andrew, Meissner, Markus, Soares, Helena, Leitão, Alexandre, Nolasco, Sofia“…To characterize the function of MOB1, we generated gain-of-function transgenic lines with a ligand-controlled destabilization domain, and loss-of-function clonal lines obtained through CRISPR/Cas9 technology. …”
Publicado 2021
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112485por Ali, Qasim, Mazhar, Muhammad Waqas, Ishtiaq, Muhammad, Hussain, Abdullah Ijaz, Bhatti, Khizar Hayat, Maqbool, Mehwish, Hussain, Tanveer, Khanum, Humaira, Sardar, Tauqeer, Mazhar, Mubashir“…Physio-biochemical studies were performed on antioxidants enzymes like superoxide dismutase (SOD), peroxidase (POD), carotenoid content (CC), malondialdehyde, hydrogen peroxide, aspartate and free amino acid contents. The activity of SOD was increased by 28.5% and activity of POD was increased by 33.33% due to foliar applied 0.5% Zn-Asp under drought stress. …”
Publicado 2021
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112486por Li, Yafeng, Hook, Jessica S, Ding, Qing, Chung, Stephen, Moreland, Jessica, Agathocleous, Michalis“…Patients typically exhibit increased neutrophil numbers in the blood and lung, and increased formation of neutrophil extracellular traps. …”
Publicado 2021
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112487por Hong, Ji-Ae, Bae, Donghyuk, Oh, Kyo-Nyeo, Oh, Dool-Ri, Kim, Yujin, Kim, Yonguk, Jeong Im, So, Choi, Eun-jin, Lee, Seul-gi, Kim, Moonjong, Jeong, Changsik, Choi, Chul Yung“…Antiradical activity was determined using 2,2-diphenyl-1-picrylhydrazyl and 2,20-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) assays. …”
Publicado 2022
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112488por Li, Hui, Li, Wenqian, Zhang, Shuangling, Qiu, Manman, Li, Zhuoran, Lin, Yongquan, Tan, Juan, Qiao, Wentao“…GADD34 promoted the EV71 internal ribosome entry site (IRES) activity through the PEST repeats and affected several other viruses. Finally, GADD34 amino acids 563 to 565 interacted with 3CD, assisting GADD34 to target the EV71 IRES. …”
Publicado 2022
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112489por Konieczny, Piotr, Andrzejewski, Wojciech, Yang, Tianyu, Urbańska, Maria, Stangierski, Jerzy, Tomczyk, Łukasz, Mikołajczak, Beata“…The study also provides novel information about electrophoretic protein profile and amino acid composition, including taurine content. …”
Publicado 2021
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112490por Yan, Wanwan, Cui, Hongrui, Engelsma, Marc, Beerens, Nancy, van Oers, Monique M., de Jong, Mart C. M., Li, Xuesong, Liu, Qinfang, Yang, Jianmei, Teng, Qiaoyang, Li, Zejun“…New antigenic properties of subgroup III viruses were associated with 11 amino acid changes in the HA protein, suggesting antigenic drift in H9N2 viruses. …”
Publicado 2022
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112491por Rojano, Elena, Jabato, Fernando M., Perkins, James R., Córdoba-Caballero, José, García-Criado, Federico, Sillitoe, Ian, Orengo, Christine, Ranea, Juan A. G., Seoane-Zonjic, Pedro“…The tool has been implemented so that it can be easily adapted to incorporate other protein features, such as domain data from other sources, amino acid k-mers and motifs. The DomFun Ruby gem is available from https://rubygems.org/gems/DomFun. …”
Publicado 2022
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112492“…Assays: TG2 was measured in human and rat urine samples by enzyme-linked immunosorbent assay (ELISA) and ε-(γ-glutamyl)-lysine by exhaustive proteolytic digestion and amino acid analysis. …”
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112493por Wu, Xiaoyun, Ayalew, Wondossen, Chu, Min, Pei, Jie, Liang, Chunnian, Bao, Pengjia, Guo, Xian, Yan, Ping“…In the coding regions (CDS), we detected 5235 editing sites, among which 1884 caused nonsynonymous amino acid changes. Of these RNA editing sites, 486 were found to generate novel possible miRNA target sites or interfere with the initial miRNA binding sites, indicating that RNA editing was related to gene regulation mediated by miRNA. …”
Publicado 2022
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112494“…The core genomes of these strains mainly consisted of genes involved in amino acid transport and metabolism, energy production and conversion and transcription. …”
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112495por Pramanick, Rinku, Nathani, Neelam, Warke, Himangi, Mayadeo, Niranjan, Aranha, Clara“…Normal microbiota utilized pathways essential for phosphatidylglycerol biosynthesis I & II, peptidoglycan biosynthesis, geranylgeranyl diphosphate biosynthesis I, mevalonate pathway, CoA biosynthesis pathway I and pyrimidine nucleotide salvage; whereas BV bacteria had characteristic aromatic amino acid biosynthesis, pentose phosphate pathway, carbohydrate degradation. …”
Publicado 2022
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112496por Rosato, Adriana E., Msiha, Engy, Weng, Bruce, Mesisca, Michael, Gnass, Ronaldo, Gnass, Silvia, Bol, Cedric, Tabuenca, Arnold, Rosato, Roberto R.“…The main goal of this study was to validate and implement the detection of the B.1.617.2 (Delta) variant utilising an open reverse transcription polymerase chain reaction (RT-PCR) platform by explicitly detecting the S-gene target failure (SGTF) corresponding to the deletion of two amino acids (ΔE156/ΔF157) characteristic of B.1.617.2 (Delta) variant. …”
Publicado 2022
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112497por Smith, Richard D., McElheny, Christi L., Izac, Jerilyn R., Gardner, Francesca M., Chandler, Courtney E., Goodlett, David R., Doi, Yohei, Johnson, J. Kristie, Ernst, Robert K.“…Detection of these modifications, including the addition of phosphoethanolamine and 4-amino-4-deoxy-l-arabinose (Ara4N), can be used for prediction of colistin resistance using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). …”
Publicado 2022
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112498por Vankrunkelsven, Wouter, Derde, Sarah, Gunst, Jan, Vander Perre, Sarah, Declerck, Emiel, Pauwels, Lies, Derese, Inge, Van den Berghe, Greet, Langouche, Lies“…As compared with lean septic mice, both obese septic groups had less muscle atrophy, liver amino acid catabolism, and inflammation with a 50% lower plasma TNFα increase (P < 0.005). …”
Publicado 2022
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112499por Boontiam, Waewaree, Bunchasak, Chaiyaphum, Kim, Yoo Yong, Kitipongpysan, Sumetee, Hong, Jinsu“…It also observed a decrease in diarrheal rate, jejunal crypt depth, blood urea nitrogen, pro-inflammatory cytokines, branched amino acids, and E. coli corresponding to the HY-supplemented levels (p < 0.05). …”
Publicado 2022
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112500“…The antioxidant capacity of milk and dairy products is mainly related to the presence of sulfur amino acids, whey proteins (especially β-lactoglobulin), vitamins A, E, and C, or β-carotene. …”
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