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  1. 112521
    “…Varied HS levels decreased the levels of blood glucose, NEFA, and amino acids (AAs) (lysine and glutamic acid) compared to a threshold (P < 0.05). …”
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    Effects of different protein levels on growth performance and stress parameters in beef calves under heat stress
  2. 112522
    “…An experiment was conducted to explore the effects of digestible amino acid (dAA) concentrations and supplemental protease on live performance and energy partitioning in broilers. …”
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    Protease supplementation reduced the heat increment of feed and improved energy and nitrogen partitioning in broilers fed maize-based diets with supplemental phytase and xylanase
  3. 112523
    “…Oxidative stress and high amounts of the oncogenesis-supporting amino acids serine and glycine were discovered by metabolomic studies. …”
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    New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming
  4. 112524
    “…The comparison of AvBD11 protein sequences in different bird species, however, suggests that some amino acid residues may have undergone convergent evolution. …”
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    The Two Domains of the Avian Double-β-Defensin AvBD11 Have Different Ancestors, Common with Potential Monodomain Crocodile and Turtle Defensins
  5. 112525
    “…However, while insects farmed for feed production are considered livestock from a regulatory perspective, systematic linking of genetic resource characterisations and fundamental phenotyping, crucial for precision breeding and feeding schemes, remains scarce even for prime insect candidates, such as the black soldier fly (BSF). …”
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    Genotype-by-Diet Interactions for Larval Performance and Body Composition Traits in the Black Soldier Fly, Hermetia illucens
  6. 112526
    “…The Fgfr2c ( C342Y/+ ) Crouzon syndrome mouse model carries a cysteine to tyrosine substitution at amino acid position 342 (Cys342Tyr; C342Y) in the fibroblast growth factor receptor 2 (Fgfr2) gene equivalent to a FGFR2 mutation commonly associated with Crouzon and Pfeiffer syndromes in humans. …”
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    Meckel’s Cartilage in Mandibular Development and Dysmorphogenesis
  7. 112527
    “…However, in analyses stratified by T2DM status, changes in five plasma metabolite factors correlated with changes in functional outcomes beyond adjustment: factor 2 (branched-chain amino acids [BCAA]) correlated with changes in NT-proBNP (ρ = − 0.291, p = 4 × 10(–4)) and 6MWD (ρ= 0.265, p = 0.011); factor 1 (medium-chain acylcarnitines;  ρ = 0.220, p = 0.008), factor 4 (long-chain dicarboxylacylcarnitines; ρ = 0.191, p = 0.019), factor 5 (long-chain acylcarnitines; ρ = 0.198, p = 0.017), and factor 8 (urea cycle metabolites; ρ = − 0.239, p = 4 × 10(–3)), correlated with change in NT-proBNP. …”
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    Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes
  8. 112528
    “…ANP prodrugs with suitable pharmacokinetics include amino acid phosphoramidates, pivaloyloxymethyl (POM) and isopropoxycarbonyloxymethyl (POC) esters, alkyl and alkoxyalkyl esters, salicylic esters, (methyl-2-oxo-1,3-dioxol-4-yl) methyl (ODOL) esters and peptidomimetic prodrugs. …”
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    Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects
  9. 112529
    “…Pathway analysis using ClueGO showed additional impacts on amino acid and lipid metabolism. There was a significant positive correlation between RNA-seq and real-time quantitative polymerase chain reaction (RT-qPCR) results for 8 of 9 metabolic-related transcripts tested. …”
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    RNA-Seq Analysis of the Growth Hormone Transgenic Female Triploid Atlantic Salmon (Salmo salar) Hepatic Transcriptome Reveals Broad Temperature-Mediated Effects on Metabolism and Other Biological Processes
  10. 112530
    “…ABSTRACT: KRAS mutations are prevalent in patients with pancreatic ductal adenocarcinoma (PDAC) and are critical to fostering tumor growth in part by aberrantly rewiring glucose, amino acid, and lipid metabolism. Obesity is a modifiable risk factor for pancreatic cancer. …”
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    Differential Effects of Dietary Macronutrients on the Development of Oncogenic KRAS-Mediated Pancreatic Ductal Adenocarcinoma
  11. 112531
    por Soliman, Ghada, Abzalimov, Rinat
    Publicado 2022
    “…METHODS: We used glucose-responsive, insulin-secreting, pancreatic beta-cell lines. mTORC1/mTORC2 were inhibited by RapaLink-1, a third-generation inhibitor encompassing rapamycin linked to an mTOR kinase inhibitor, or rapamycin, compared to the control. …”
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    Differential Effects of mTORC1 and mTORC2 Inhibition on High-Resolution Mass Spectrometry (HRMS) Metabolomics and the Internal Exposome in Pancreatic Beta Cell Lines
  12. 112532
    “…More than two hundred metabolites were identified in feces; branched-chain amino acids leucine and isoleucine decreased their relative concentrations in 800 CPH in comparison to HFD. …”
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    Chickpea Protein Hydrolysate Ameliorates the Impact of Feeding a High-Fat-Diet-Induced Obesity in Mice by Modulating Inflammation
  13. 112533
    “…Msr proteins and various oxidoreductases can reduce oxidized Cys and Met amino acid residues of damaged proteins to recover protein function. …”
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    A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase (msrA) Expression for Oxidative Stress Adaptation
  14. 112534
    “…This is based on the conversion of L-aspartic acid, the regular form of the amino acid in our proteins, into D-aspartic acid, its mirror image. …”
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    Application of Aspartic Acid Racemization for Age Estimation in a Spanish Sample
  15. 112535
    “…In addition to lipids, we also documented metabolites belonging to amino acids and purine nucleotides (such as 2-Oxo-4-methylthiobutanoic acid, synthesised by acireductone dioxygenase 1 (ADI1) enzyme), which showed higher levels in SCs. …”
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    Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer
  16. 112536
    “…We found that females were more affected by 21A, whereas males by 21J variant (χ2 = 4.57; p ≤ 0.05, n = 32). The amino acid substitution ORF7a:P45L in the Delta isolates found to be significantly associated with disease severity. …”
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    Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan
  17. 112537
    “…Acute intoxication depresses neural activity via complex signaling mechanisms by enhancing inhibition mediated by gamma-amino butyric acid (GABA), and by decreasing excitatory glutamatergic effects. …”
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    Cortical GABA levels are reduced in young adult binge drinkers: Association with recent alcohol consumption and sex
  18. 112538
    “…Functional assessment of the collective MAGs showed a propensity for amino acid utilization over carbohydrate metabolism. …”
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    Microbial Tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station
  19. 112539
    “…The major H3 C-IVA clade contained an N156H amino acid substitution, but hemagglutination inhibition (HI) assays demonstrated no significant antigenic drift. …”
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    Genetic and Antigenic Characterization of an Expanding H3 Influenza A Virus Clade in U.S. Swine Visualized by Nextstrain
  20. 112540
    “…MDV mutations conferred an attenuated phenotype to other IAV strains, the same amino acid changes did not significantly attenuate the pandemic A/California/04/09 H1N1 (pH1N1) strain. …”
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    Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine
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