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112541por Mucci, Nicholas C., Jones, Katarina A., Cao, Mengyi, Wyatt, Michael R., Foye, Shane, Kauffman, Sarah J., Richards, Gregory R., Taufer, Michela, Chikaraishi, Yoshito, Steffan, Shawn A., Campagna, Shawn R., Goodrich-Blair, Heidi“…We show that each phase of the life cycle is metabolically distinct, with significant differences including those in the tricarboxylic acid cycle and amino acid pathways. Our findings demonstrate that symbiotic life cycles can be defined by reproducible stage-specific chemical signatures, enhancing our broad understanding of metabolic processes that underpin a three-way symbiosis.…”
Publicado 2022
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112542por Tanelian, Arax, Nankova, Bistra, Miari, Mariam, Nahvi, Roxanna J., Sabban, Esther L.“…Before SPS, the SPS-S subgroup harbored microbiota with an overall pro-inflammatory phenotype, whereas SPS-R subgroup had microbiota with an overall anti-inflammatory phenotype, with predictive functional pathways enriched in carbohydrate and lipid metabolism and decreased in amino acid metabolism and neurodegenerative diseases. …”
Publicado 2022
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112543por Ma, Jianfeng, Chen, Jingyun, Gan, Mailin, Chen, Lei, Zhao, Ye, Zhu, Yan, Niu, Lili, Zhang, Shunhua, Zhu, Li, Shen, Linyuan“…KEGG pathway enrichment analysis of annotated metagenomes revealed that protein synthesis and amino acid metabolism pathways were significantly enriched in pigs at the early growth stage, which may be related to nutritional requirements of pigs during this stage. …”
Publicado 2022
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112544por Maki, Shinichiro, Islam, Md Shafiqul, Itoh, Tomohito, Nurimoto, Masanobu, Yabuki, Akira, Furusawa, Yu, Kamishina, Hiroaki, Kobatake, Yui, Rakib, Tofazzal Md, Tacharina, Martia Rani, Yamato, Osamu“…A common DM-associated mutation is a single nucleotide substitution that causes an amino acid substitution (c.118G>A, p.E40K) in the canine SOD1 gene. …”
Publicado 2022
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112545por Fan, Jing, Chen, Jiayi, Wu, Haochen, Lu, Xin, Fang, Xibi, Yin, Fuquan, Zhao, Zhihui, Jiang, Ping, Yu, Haibin“…ABSTRACT: Chitosan oligosaccharide (COS) is a variety of oligosaccharides, and it is also the only abundant basic amino oligosaccharide in natural polysaccharides. …”
Publicado 2022
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112546por Han, Ying, Chen, Le, Liu, Jingyun, Chen, Jie, Wang, Chunyang, Guo, Yu, Yu, Xuebin, Zhang, Chenghong, Chu, Haiying, Ma, Haiying“…We detected the levels of synapse-related proteins, HDACs, tau phosphorylation, and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors using Western blotting and immunohistochemistry. …”
Publicado 2022
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112547“…In contrast, significantly increased levels of amino acids including L-aspartic acid, beta-alanine, 5-hydroxy-L-tryptophan, L-glutamic acid, and lysophosphatidylcholines (all p < 0.05) were found. …”
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112548por Sevenich, Marc, van den Heuvel, Joop, Gering, Ian, Mohrlüder, Jeannine, Willbold, Dieter“…It has been widely assumed that the reason for its increased cell entry compared with SARS-CoV (2002) is due to alterations in the viral spike protein, where single amino acid residue substitutions can increase affinity for hACE2. …”
Publicado 2022
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112549por Wu, Qiong, Zhang, Lu, Xu, Xiazhen, Zhang, Yi, Shi, Jiajian, Lin, Xu, Chen, Wannan“…VCPIP1 and its C-terminal amino acids 863 to 1221 upregulated the HBx protein expression, with or without HBV infection. …”
Publicado 2022
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112550por Liu, Qinmei, Wang, Jinna, Hou, Juan, Wu, Yuyan, Zhang, Hengduan, Xing, Dan, Gao, Jian, Li, Chunxiao, Guo, Xiaoxia, Jiang, Yuting, Gong, Zhenyu, Zhao, Tongyan“…Full-length nucleotide and amino acid homology analyses showed that ZJWZ2019 and Wenzhou DF serum isolates ZJWZ-62/2019 (MW582816) and ZJWZ-18/2019 (MW582815) had the highest homology. …”
Publicado 2022
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112551“…Also, the remaining solids contained 15–17% (w/w) protein, having 44–45% essential amino acids. Overall, the results suggest that herring co-product silage is a valuable source of fish oil and protein hydrolysates, paving the way for ensilaging based-biorefining of herring co-products into multiple products. …”
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112552por Luna Velez, Maria V., Paulino da Silva Filho, Omar, Verhaegh, Gerald W., van Hooij, Onno, El Boujnouni, Najoua, Brock, Roland, Schalken, Jack A.“…In this study, we evaluated the CPP‐mediated delivery of this AON into castration‐resistant prostate cancer cell line models 22Rv1, DuCaP (dura mater cancer of the prostate), and VCaP (vertebral cancer of the prostate). …”
Publicado 2022
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112553por Romani, Lorenza, Del Chierico, Federica, Macari, Gabriele, Pane, Stefania, Ristori, Maria Vittoria, Guarrasi, Valerio, Gardini, Simone, Pascucci, Giuseppe Rubens, Cotugno, Nicola, Perno, Carlo Federico, Rossi, Paolo, Villani, Alberto, Bernardi, Stefania, Campana, Andrea, Palma, Paolo, Putignani, Lorenza“…Faecalibacterium and reduced fatty acid and amino acid degradation were proposed as specific COVID-19 disease traits, possibly associated to restrained severity of SARS-CoV-2–infected children. …”
Publicado 2022
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112554por Vacca, Francesca, Gomes, Ana S., Murashita, Koji, Cinquetti, Raffella, Roseti, Cristina, Barca, Amilcare, Rønnestad, Ivar, Verri, Tiziano, Bossi, Elena“…KEY POINTS: Two slc15a2‐type genes, slc15a2a and slc15a2b coding for PepT2‐type peptide transporters were found in the Atlantic salmon. slc15a2a transcripts, widely distributed in the fish tissues, are abundant in the brain and gills, while slc15a2b transcripts are mainly expressed in the kidney and distal gastrointestinal tract. Amino acids involved in vertebrate Slc15 transport function are conserved in PepT2a and PepT2b proteins. …”
Publicado 2022
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112555por Liang, Zhao, Ali, Qurban, Wang, Yujie, Mu, Guangyuan, Kan, Xuefei, Ren, Yajun, Manghwar, Hakim, Gu, Qin, Wu, Huijun, Gao, Xuewen“…The Cry31Aa protein was composed of 802 amino acids with a molecular weight of 90.257 kDa and contained a conserved delta-endotoxin insecticidal domain. …”
Publicado 2022
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112556por Mishra, Seema“…Analyses of viral T cell epitopes and primary anchor residue mutations was done to understand the role it may play in the evolution as a molecule with likely enhanced immune response and consequent immunopathogenesis. RESULTS: Few amino acid substitution mutations are observed, most probably due to the ribosomal frameshifting, and these mutations may not be detrimental to its functioning. …”
Publicado 2022
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112557“…After several trials, a 59 amino acid (453ARG-510VAL) peptide-cut (Expasy-server) of the wild-type spike RBD with some desired mutants (THR500SER/THR500GLY/THR500ALA/THR500CYS) was blindly/competitively docked (PyMOL-V2.2.2) to block the Omicron-ACE2 binding. …”
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112558por Farrukee, Rubaiyea, Gunalan, Vithiagaran, Maurer-Stroh, Sebastian, Reading, Patrick C., Hurt, Aeron C.“…Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). …”
Publicado 2022
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112559por Dodantenna, Niranjan, Ranathunga, Lakmal, Chathuranga, W. A. Gayan, Weerawardhana, Asela, Cha, Ji-Won, Subasinghe, Ashan, Gamage, Nuwan, Haluwana, D. K., Kim, YongKwan, Jheong, WeonHwa, Poo, Haryoung, Lee, Jong-Soo“…Particularly notable is that ASFV EP364R had a region of homology with the stimulator of interferon genes (STING) protein containing a 2′,3′-cGAMP-binding motif and point mutations in the Y76S and N78A amino acids of EP364R that impaired interaction with 2′,3′-cGAMP and restored subsequent antiviral responses. …”
Publicado 2022
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112560por Patterson Rosa, Laura, Martin, Katie, Vierra, Micaela, Lundquist, Erica, Foster, Gabriel, Brooks, Samantha A., Lafayette, Christa“…We also report a complete link between the previously reported KIT W19 allele and this mutation. …”
Publicado 2022
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