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  1. 112721
    “…BACKGROUND: SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA), metabotropic glutamate (mGlu) and N-methyl-D-aspartic acid (NMDA) glutamate receptors, as well as cytoskeletal elements. …”
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    Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication
  2. 112722
    “…Ingredients were categorised as follows: (i) milk products (n = 6), (ii) cereals (n = 10), (iii) root and pulp products (n = 5), (iv) vegetable proteins (n = 11), (v) meat and fish meal (n = 2), (vi) medication (n = 3), (vii) amino acids (n = 4), (viii) minerals (n = 16), (ix) acid salts (n = 4), (x) acids (n = 10). …”
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    Measurements of the acid-binding capacity of ingredients used in pig diets
  3. 112723
    “…In this study using the bioinformatics tools we tried to present a reliable model for the protein-x interaction with C/EBPα. RESULTS: The amino acid sequence of protein-x was extracted from UniProt [UniProt:Q80IU5] and the x-ray crystal structure of the partial CCAAT-enhancer α [PDB:1NWQ] was retrieved from the Protein Data Bank (PDB). …”
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    Protein-x of hepatitis B virus in interaction with CCAAT/enhancer-binding protein α (C/EBPα) - an in silico analysis approach
  4. 112724
    “…CONCLUSIONS: The ETn insertion in lop11 mice results in abolished HSF4b function. Loss of 132 amino acids from the COOH-terminus in HSF4b(lop11) results in the failure of trimer formation and subsequent failure of HSE-mediated DNA binding and transactivation. …”
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    Functional analysis of the Hsf4(lop11) allele responsible for cataracts in lop11 mice
  5. 112725
    “…A bifunctional chelator (BFC) 1,4,7,10-tetraazadodecane-N,N',N",N"'-tetraacetic acid (DOTA) or 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo [6.6.6] icosane-1-ylamino) methyl) benzoic acid (AmBaSar) was then conjugated to the phage surface for (64)Cu(2+) chelation. …”
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    Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging
  6. 112726
    “…RESULTS: As predicted, pCTRP5 showed a 92% DNA homology and 98% amino acid homology with human CTRP5 (hCTRP5). Bioinformatic analysis revealed the presence of an alternate in-frame translational start site upstream to the presumed initiator codon. …”
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    Cloning, characterization, and expression analysis of the pig (Sus scrofa) C1q tumor necrosis factor-related protein-5 gene
  7. 112727
    “…RESULTS: Sequencing the G. lovleyi strain SZ genome revealed a 3.9 Mbp chromosome with 54.7% GC content (i.e., the percent of the total guanines (Gs) and cytosines (Cs) among the four bases within the genome), and average amino acid identities of 53–56% compared to other sequenced Geobacter spp. …”
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    Genomic determinants of organohalide-respiration in Geobacter lovleyi, an unusual member of the Geobacteraceae
  8. 112728
    “…Instead, two ORFs were identified in each L1A, L1B and L2 dsRNAs, whose deduced amino acid sequences were homologous with a major capsid protein (5’-ORF) and a RNA-dependent RNA polymerase (3’-ORF) belonging to the Totiviridae family. …”
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    Molecular characterization of totiviruses in Xanthophyllomyces dendrorhous
  9. 112729
    “…In another patient, a variation (G8572A) in ATP synthase 8 (ATpase8) led to the introduction of a stop codon or termination at amino acid position 69. Haplogroup/phylogenetic analysis of mtDNA showed that primary congenital glaucoma patients belong to three macrohaplogroups: M (4), N (15), and L (1). …”
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    Mitochondrial DNA nucleotide changes in primary congenital glaucoma patients
  10. 112730
    “…METHODS: The study was approved by the “Comité de Etica de Protocolos de Investigación del Departamento de Docencia e Investigación del Hospital Italiano de Buenos Aires” with the number “1262” and included only patients who provided written informed consent. …”
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    Endocrine and inflammatory profiles in type 2 diabetic patients with and without major depressive disorder
  11. 112731
    “…The mutation cosegregated in the mutant line, since all five additional small-eyed mice from this line showed the same mutation. …”
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    Novel small-eye allele in paired box gene 6 (Pax6) is caused by a point mutation in intron 7 and creates a new exon
  12. 112732
    “…RESULTS: HuScFv derived from four huscfv-phagemid transformed E. coli clones (no. 2, 19, 23 and 27) showed different amino acid sequences particularly at the CDRs. Cells infected with A/H5N1 influenza viruses (both adamantane sensitive and resistant) that had been exposed to the HuScFv had reduced virus release and intracellular virus. …”
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    Human monoclonal ScFv that bind to different functional domains of M2 and inhibit H5N1 influenza virus replication
  13. 112733
    “…RESULTS: Through protein-protein docking studies, it was identified that the amino acid residues VAL342, GLU347, SER349, TYR355, SER388, ASN395, HIS398 and ALA387 of gH-gL complex play an active role in its binding activity with gB. …”
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    Computational repositioning of ethno medicine elucidated gB-gH-gL complex as novel anti herpes drug target
  14. 112734
    “…METHODS: Rats were treated orally with GBR bioactives (phenolics), acylated steryl glucosides (ASG), γ-amino butyric acid (GABA), and γ-oryzanol (ORZ) at 100 and 200 mg/kg, Remifemin (REM) at 10 mg/kg and 20 mg/kg, or estrogen (EST) at 0.2 mg/kg. …”
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    Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes
  15. 112735
    “…The solute carrier family 7 (anionic amino acid transporter light chain, xc-system), member 11 (SLC7A11) gene in the interferon pathway, reported to be involved in the development of chemoresistance, was downregulated by 15-fold. …”
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    Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells
  16. 112736
    “…Water quality and the toxin beta methyl-amino-alanine produced by cyanobacteria are suspected environmental triggers. …”
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    Mapping amyotrophic lateral sclerosis lake risk factors across northern New England
  17. 112737
    “…METHODS: An online self-administered survey was conducted among eligible medical students and recent graduates from the University of Buenos Aires (UBA). Sampling was from lists of email addresses of students enrolled in two required courses. …”
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    Smoking Behavior and Use of Tobacco Industry Sponsored Websites Among Medical Students and Young Physicians in Argentina
  18. 112738
    “…Alanine-scanning mutagenesis of the K-rich domain, in the region spanning residues 735 and 750, has uncovered the precise amino acid determinants required for the productive engagement of RNase R on tmRNA-rescued ribosomes. …”
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    Non-stop mRNA decay: a special attribute of trans-translation mediated ribosome rescue
  19. 112739
    “…The corresponding (99m)Tc complex (4a) was obtained in high radiochemical yields, was stable in vitro for 24 h during amino acid challenge and serum stability assays, and showed increased hydrophilicity by log P analysis compared to an analogous complex with nonfunctionalized pyridine rings (2a). …”
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    Clickable, Hydrophilic Ligand for fac-[M(I)(CO)(3)](+) (M = Re/(99m)Tc) Applied in an S-Functionalized α-MSH Peptide
  20. 112740
    “…The resulting probe, (99m)Tc-SAAC-S(0)2, was then evaluated by in vitro cell uptake studies using two α(v)β(6) positive cell lines (human lung adenocarcinoma cell line HCC4006 and pancreatic cancer cell line BxPC-3) and two α(v)β(6) negative cell lines (human lung adenocarcinoma cell line H838 and human embryonic kidney cell line 293T). …”
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    (99m)Tc-Labeled Cystine Knot Peptide Targeting Integrin α(v)β(6) for Tumor SPECT Imaging
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