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112781por Varney, Shawn M., Ng, Patrick C., Perez, Crystal A., Araña, Allyson A., Austin, Edwin R., Ramos, Rosemarie G., Bebarta, Vikhyat S.“…BACKGROUND: Dietary supplement use (protein/amino acids, weight-loss supplements, performance enhancers) is common among U.S. military members. …”
Publicado 2017
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112782por Shibata, Nozomu, Suetsugu, Mari, Kakeshita, Hiroshi, Igarashi, Kazuaki, Hagihara, Hiroshi, Takimura, Yasushi“…Biomass-degrading enzymes from strain KSM-F532 were fractionated and analyzed, and a xylanase, named PspXyn10, was identified. The amino acid sequence of PspXyn10 was determined by cDNA analysis: the enzyme shows a modular structure consisting of glycoside hydrolase family 10 (GH10) and carbohydrate-binding module family 1 (CBM1) domains. …”
Publicado 2017
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112783por Zuo, Hua-Li, Zhao, Jie, Wang, Yi-Tao, Xia, Zhi-Ning, Hu, Yuan-Jia, Yang, Feng-Qing“…The gelatins made by donkey, horse, bovine, pig, mule shares much in common with each other, not only in contents of amino acids but also the profiles of protein in sodium dodecyl sulfate polyacrylamide gel electrophoresis, isoelectric focusing, gel filtration chromatography and two-dimensional electrophoresis. …”
Publicado 2017
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112784por Manyevitch, Roni, Protas, Matthew, Scarpiello, Sean, Deliso, Marisa, Bass, Brittany, Nanajian, Anthony, Chang, Matthew, Thompson, Stefani M., Khoury, Neil, Gonnella, Rachel, Trotz, Margit, Moore, D. Blaine, Harms, Emily, Perry, George, Clunes, Lucy, Ortiz, Angélica, Friedrich, Jan O., Murray, Ian V.J.“…Metabolic markers were glutathione, glucose, lactate, pyruvate, and 8 other amino acids. Only studies that measured markers in AD and controls (Ctl), provided means, standard er-rors/deviation, and subject numbers were included. …”
Publicado 2018
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112785por King, Rebecca, Struebing, Felix L., Li, Ying, Wang, Jiaxing, Koch, Allison Ashley, Cooke Bailey, Jessica N., Gharahkhani, Puya, MacGregor, Stuart, Allingham, R. Rand, Hauser, Michael A., Wiggs, Janey L., Geisert, Eldon E.“…Of these five nonsynonymous SNPs in Pou6f2, two resulted in changes in the amino acid proline which could result in altered secondary structure affecting protein function. …”
Publicado 2018
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112786por Yamamoto, Kaneyoshi, Yamanaka, Yuki, Shimada, Tomohiro, Sarkar, Paramita, Yoshida, Myu, Bhardwaj, Neerupma, Watanabe, Hiroki, Taira, Yuki, Chatterji, Dipankar, Ishihama, Akira“…Possible mechanisms of altered distribution of RNAP inside prophages are discussed. IMPORTANCE The 91-amino-acid-residue small-subunit omega (the rpoZ gene product) of Escherichia coli RNA polymerase plays a structural role in the formation of RNA polymerase (RNAP) as a chaperone in folding the largest subunit (β′, of 1,407 residues in length), but except for binding of the stringent signal ppGpp, little is known of its role in the control of RNAP function. …”
Publicado 2018
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112787“…Seven protein degradation-, three fat degradation-related genes were upregulated, and no genes related to the de novo synthesis of amino acids and fatty acids were significantly upregulated. …”
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112788“…The negative control (NC) diet was formulated to be lower in metabolizable energy (∼86 kcal/kg diet) and digestible amino acids (1 to 2%) compared to PC. The other 4 treatments were based on the NC and they were either supplemented with xylanase (X), amylase (A), protease (P), or a combination of X, A, and P (XAP; to provide 2,000 U of X, 200 U of A, and 4,000 U of P/kg diet). …”
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112789por Nepomuceno, Diane, Kuei, Chester, Dvorak, Curt, Lovenberg, Timothy, Liu, Changlu, Bonaventure, Pascal“…It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via G(αq)-coupling. …”
Publicado 2018
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112790por Kilcawley, Kieran N., Faulkner, Hope, Clarke, Holly J., O’Sullivan, Maurice G., Kerry, Joseph P.“…Some studies have highlighted potential correlation of pasture with enhanced “barny” or “cowy” sensory attributes and subsequently linked these to accumulation of p-cresol from the metabolism of β-carotene and aromatic amino acids or possibly isoflavones in the rumen. p-Cresol has also been suggested as a potential biomarker for pasture derived dairy products. …”
Publicado 2018
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112791por Whitham, Jason M., Moon, Ji-Won, Rodriguez, Miguel, Engle, Nancy L., Klingeman, Dawn M., Rydzak, Thomas, Abel, Malaney M., Tschaplinski, Timothy J., Guss, Adam M., Brown, Steven D.“…At and below pH 6.24, amino acids including glutamate and valine; long-chain fatty acids, their iso-counterparts and glycerol conjugates; glycolysis intermediates 3-phosphoglycerate, glucose 6-phosphate, and glucose accumulated intracellularly. …”
Publicado 2018
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112792por Lin, Shu-fei, Bois, Frederic, Holden, Daniel, Nabulsi, Nabeel, Pracitto, Richard, Gao, Hong, Kapinos, Michael, Teng, Jo-ku, Shirali, Anupama, Ropchan, Jim, Carson, Richard E., Elmore, Charles S., Vasdev, Neil, Huang, Yiyun“…The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABA(A), GABA(B), and GABA(C) groups. …”
Publicado 2017
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112793por Maté-Muñoz, José Luis, Lougedo, Juan H., Garnacho-Castaño, Manuel V., Veiga-Herreros, Pablo, Lozano-Estevan, María del Carmen, García-Fernández, Pablo, de Jesús, Fernando, Guodemar-Pérez, Jesús, San Juan, Alejandro F., Domínguez, Raúl“…BACKGROUND: β-Alanine (BA) is a non-essential amino acid that has been shown to enhance exercise performance. …”
Publicado 2018
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112794por Xi, Juemin, Chen, Junying, Xu, Miaoling, Yang, Hongying, Wen, Songjiao, Pan, Yue, Wang, Xiaodan, Ye, Chao, Qiu, Lijuan, Sun, Qiangming“…The most common non-synonymous substitution V77A in the E7 was observed in the sequences encoding the α-helix. 63G in the E7 was determined to be the only one positively selected site in the HPV-58 E6/E7 sequences. Six non-synonymous amino acid substitutions (including S71F and K93 N in the E6, and T20I, G41R, G63S/D, and V77A in the E7) were affecting multiple putative epitopes for both CD4(+) and CD8(+) T-cells. …”
Publicado 2018
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112795“…Metabolome analyses indicated OGT-induced changes in short-chain acylcarnitines (6.00 ± 0.53 vs. 3.99 ± 0.23 μmol/L, p < 0.001), long-chain acylcarnitines (0.13 ± 0.004 vs. 0.11 ± 0.002 μmol/L, p < 0.001) and amino acids (2.18 ± 0.11 vs. 1.87 ± 0.08 μmol/L, p < 0.05). …”
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112796“…One accessory protein of IAV, PB1-F2, was associated with pathogenicity of pandemic and zoonotic IAV. This short (90-amino-acid) peptide does not harbor an enzymatic function. …”
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112797por Tsuru, Michiyo, Ono, Atsushi, Umeyama, Hideaki, Takeuchi, Masahiro, Nagata, Kensei“…We isolated the protein, determined its amino acid sequence, and identified it as chemokine (C-X-C motif) ligand 7 (CXCL7). …”
Publicado 2018
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112798“…Compared with the mammary gland of AH-fed cows, the marked expression changes found in the mammary gland of CS group were for genes involved in reduced mammary growth/development (COL4A2, MAPK3, IKBKB, LGALS3), less oxidative phosphorylation (ATPsynGL, ATP6VOA1, ATP5H, ATP6VOD1, NDUFC1), enhanced lipid uptake/metabolism (SLC27A6, FABP4, SOD2, ACADM, ACAT1, IDH1, SCP2, ECHDC1), more active fatty acid beta-oxidation (HMGCS1), less amino acid/protein transport (SLC38A2, SLC7A8, RAB5a, VPS18), reduced protein translation (RPS6, RPS12, RPS16, RPS19, RPS20, RPS27), more proteasome- (PSMC2, PSMC6, PSMD14, PSMA2, PSMA3) and ubiquitin-mediated protein degradation (UBE2B, UBE2H, KLHL9, HSPH1, DNAJA1 and CACYBP), and more protein disassembly-related enzymes (SEC63, DNAJC3, DNAJB1, DNAJB11 and DNAJC12). …”
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112799“…Secondary outcomes included were early allograft dysfunction (EAD) in the first seven days; serum measures of liver functions as bilirubin, aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), and international normalized ratio (INR) on days 1–7; major complications as defined by a Clavien-Dindo score ≥ 3; and patient and graft survival and biliary complications at six months. …”
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112800por de Rezende, Izabela Maurício, Sacchetto, Lívia, Munhoz de Mello, Érica, Alves, Pedro Augusto, Iani, Felipe Campos de Melo, Adelino, Talita Émile Ribeiro, Duarte, Myrian Morato, Cury, Ana Luísa Furtado, Bernardes, André Felipe Leal, Santos, Tayrine Araújo, Pereira, Leonardo Soares, Dutra, Maria Rita Teixeira, Ramalho, Dario Brock, de Thoisy, Benoit, Kroon, Erna Geessien, Trindade, Giliane de Souza, Drumond, Betânia Paiva“…We also detected a cluster characterized by two synapomorphies (amino acid substitutions) that contained YFV only associated with NHP what should be further investigated. …”
Publicado 2018
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