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  1. 112801
    “…In the metabolomic study, acute AMPH induced an elevation of isoleucine and leucine, branched chain amino acids (BCAA), whereas the level of hexoses was reduced in Bl6. …”
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    Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains
  2. 112802
    “…Since the biosynthetic pathway is hypothesised to have evolved convergently in plants as well, this would suggest that there is only one universal series of unique intermediates by which amino acids are efficiently converted into CNglcs in different Kingdoms of Life. …”
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    Cyanogenesis in Arthropods: From Chemical Warfare to Nuptial Gifts
  3. 112803
    “…Transcriptomic profiling reveals that core functions shared by CaGdt1 and CaPmr1 are involved in the regulation of cellular transport of metal ions and amino acids. However, CaGdt1 has distinct functions from CaPmr1. …”
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    CaGdt1 plays a compensatory role for the calcium pump CaPmr1 in the regulation of calcium signaling and cell wall integrity signaling in Candida albicans
  4. 112804
    “…The putative products of genes that were upregulated in PB-parasites were linked to nucleosomes, cytoplasm and membrane-bound organelles, which suggest that parasites in this niche undergo cell division in line with prior findings. …”
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    Expression profiling of Trypanosoma congolense genes during development in the tsetse fly vector Glossina morsitans morsitans
  5. 112805
    “…BACKGROUND: Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC) cell lines to human liver tumours, specifically in the expression of deregulated metabolic targets in clinical tissue samples. …”
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    Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
  6. 112806
    “…In these data, the K1-like msp1 block 2 alleles are most diverse and encode 225 distinct amino acid sequences, compared with 123 different MAD20-like, 9 RO33-like and 6 MR type sequences. …”
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    An expanded global inventory of allelic variation in the most extremely polymorphic region of Plasmodium falciparum merozoite surface protein 1 provided by short read sequence data
  7. 112807
    “…METHODS: A total of 1,821 Spn isolates (<6 years old) from sterile fluids were received at NRL between January 2010 and December 2016 from 150 hospitals, 24 provinces and Buenos Aires city; 1029 (56.5%) <2 years old. Isolates were serotyped by Quellung, MICs were performed by agar dilution (CLSI) and resistance genes by PCR. …”
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    1429. Emergence of Multidrug-resistant Serotype 24 Among Children Under 2 Years Old With Invasive Pneumococcal Disease After the Introduction of PCV13 in Argentina
  8. 112808
    “…The chains are linked by weak C—H⋯O hydrogen bonds, forming a three-dimensional framework. …”
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    Crystal structures and the Hirshfeld surface analysis of (E)-4-nitro-N′-(o-chloro, o- and p-methyl­benzyl­idene)benzene­sulfono­hydrazides
  9. 112809
    “…L-cysteine is the major thiol and an essential amino acid for proliferation and anti-oxidative defense of E. histolytica trophozoites. …”
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    Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist Entamoeba histolytica by Screening of Microbial Secondary Metabolites
  10. 112810
    “…METHOD: Thirty-five full-length pk41 sequences from clinical isolates of Malaysia along with four laboratory lines (along with H-strain) were downloaded from public databases. …”
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    The Plasmodium knowlesi Pk41 surface protein diversity, natural selection, sub population and geographical clustering: a 6-cysteine protein family member
  11. 112811
    “…Type III NER comprises biogenic NER (bioNER) after degradation of the xenobiotic chemical and anabolic formation of natural biomolecules like amino acids and phospholipids, and other biomass compounds. …”
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    A unified approach for including non-extractable residues (NER) of chemicals and pesticides in the assessment of persistence
  12. 112812
    por Roelfes, Gerard
    Publicado 2019
    “…Therefore, expanded genetic code methodologies were used to introduce metal binding unnatural amino acids during LmrR biosynthesis in vivo. These ARMs have been successfully applied in Cu(II) catalyzed Friedel–Crafts alkylation of indoles. …”
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    LmrR: A Privileged Scaffold for Artificial Metalloenzymes
  13. 112813
    “…Moreover, PCs with odd-chain fatty acids, branched-chain amino acids, 3-methyl-2-oxovaleric acid and glutamate changed over time along with disease progression among diabetes cases. …”
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    Plasma metabolites associated with type 2 diabetes in a Swedish population: a case–control study nested in a prospective cohort
  14. 112814
    “…The molecular analysis of the HA genes (influenza A subtypes) revealed similar mutations to those reported worldwide. Generally, amino acid substitutions were most frequently found in head domain in H1N1 pandemic viruses, while localized mainly in the stem region in H3N2 viruses. …”
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    Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009–2017
  15. 112815
    “…We can distinguish by flow cytometry NK cell populations expressing the most common KIR2DL1-C(245) allotypes from those expressing the most common KIR2DL1-R(245) allotypes, and we show that the informative differential binding anti-KIR2DL1/S1 clone 1127B is determined by amino acid residue T(154). Although both KIR2DL1-C(245) and KIR2DL1-R(245) subtypes can be co-expressed in the same cell, NK cells preferentially express one or the other. …”
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    Novel Approach to Cell Surface Discrimination Between KIR2DL1 Subtypes and KIR2DS1 Identifies Hierarchies in NK Repertoire, Education, and Tolerance
  16. 112816
    “…A total of 301 B. rapa putative C2H2-ZFP (BrC2H2-ZFP) genes were identified from the available Brassica genome databases, and further characterized through analysis of conserved amino acid residues in C2H2-ZF domains and their organization, subcellular localization, phylogeny, additional domain, chromosomal location, synteny relationship, Ka/Ks ratio, and expression pattern. …”
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    Comprehensive genomic survey, structural classification and expression analysis of C2H2 zinc finger protein gene family in Brassica rapa L.
  17. 112817
    “…After conservation analysis of SRD5A2, a novel 3D protein model was constructed to locate the exact position of amino acids in the tertiary structure and predict their effect on protein function and substrate interaction. …”
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    MON-219 In Silico and in Vitro Studies of Human 5α-Reductase Type II Variants in Search for Activating Variants Explaining Androgen Excess Reveal New Loss-Of-Function Variants
  18. 112818
    “…SIFT, PolyPhen 2, Mutation Taster) and affect amino acids that are highly conserved among homologues (GERP scores). …”
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    MON-207 Identification of Monogenic Causes of Polycystic Ovary Syndrome by High Throughput Sequencing
  19. 112819
    “…Introduction: Oral semaglutide contains the GLP-1 analog semaglutide co-formulated with the absorption enhancer, sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Aims: This trial investigated (A) the effect of oral semaglutide and SNAC alone on the pharmacokinetics (PK) of levothyroxine (thyroxine), a frequently used oral medication with similar dosing instructions to oral semaglutide, and (B) the effect of multiple co-administered tablets on oral semaglutide PK. …”
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    SAT-140 A Drug-Drug Interaction Trial of Oral Semaglutide with Levothyroxine and Multiple Coadministered Tablets
  20. 112820
    “…. - Variants that disrupt the p.Tyr127Cys amino acid residue in SRYgene has been observed in affected individuals.…”
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    SAT-297 Mutation in SRY Gene Presenting as Syndromic 46XY Disorder of Sexual Differentiation (DSD)
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