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  1. 113081
    “…HERV-K-MEL is significantly expressed in the majority of dysplastic and normal naevi, as well as other tumors like sarcoma, lymphoma, bladder and breast cancer. An amino acid sequence similar to HERV-K-MEL, recognized to cause a significant protective effect against melanoma, is shared by the antigenic determinants expressed by some vaccines such as BCG, vaccinia virus and the yellow fever virus. …”
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    Human endogenous retroviruses and cancer prevention: evidence and prospects
  2. 113082
    “…Gene expression was analyzed using quantitative real-time reverse-transcription PCR. Enzyme-linked immunosorbent assay was used to quantify the concentration of VEGF protein in each retina. …”
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    Diabetes changes expression of genes related to glutamate neurotransmission and transport in the Long-Evans rat retina
  3. 113083
    “…Four mAbs recognized epitopes on hCGβcf-only (e.g., epitopes β(11) and β(13)) and six mAbs epitopes on the remote hCGβ-carboxyl-terminal peptide (epitopes β(8) and β(9) corresponding to amino acids 135–144 and 111–116, respectively). For routine diagnostic measurements, methods are used that either detect hCG-only, hCGβ-only, or hCG together with hCGβ or hCG together with hCGβ and hCGβcf. …”
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    Candidate epitopes for measurement of hCG and related molecules: the second ISOBM TD-7 workshop
  4. 113084
    por Dhermain, Frederic
    Publicado 2014
    “…Many issues have been identified: the variety of MRI and PET machines (and amino-acid tracers), the heterogeneity of the protocols used for image acquisition and post-treatment, the geometric distortion and the unreliable algorithms for co-registration of brain anatomy with functional maps, and the semi-quiescent but highly invasive HGG cells. …”
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    Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches
  5. 113085
    “…Three experiments were conducted to evaluate the ME value, standardized ileal digestibility (SID) of amino acids (AA) of fish meal, and the effects of single cell protein (Prosin and Protide) replacing fish meal in diet on growth performance, nutrient digestibility and intestinal morphology in weaned piglets. …”
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    Effects of Single Cell Protein Replacing Fish Meal in Diet on Growth Performance, Nutrient Digestibility and Intestinal Morphology in Weaned Pigs
  6. 113086
    por Fuks, Kateryna B., Weinmayr, Gudrun, Foraster, Maria, Dratva, Julia, Hampel, Regina, Houthuijs, Danny, Oftedal, Bente, Oudin, Anna, Panasevich, Sviatlana, Penell, Johanna, Sommar, Johan N., Sørensen, Mette, Tiittanen, Pekka, Wolf, Kathrin, Xun, Wei W., Aguilera, Inmaculada, Basagaña, Xavier, Beelen, Rob, Bots, Michiel L., Brunekreef, Bert, Bueno-de-Mesquita, H. Bas, Caracciolo, Barbara, Cirach, Marta, de Faire, Ulf, de Nazelle, Audrey, Eeftens, Marloes, Elosua, Roberto, Erbel, Raimund, Forsberg, Bertil, Fratiglioni, Laura, Gaspoz, Jean-Michel, Hilding, Agneta, Jula, Antti, Korek, Michal, Krämer, Ursula, Künzli, Nino, Lanki, Timo, Leander, Karin, Magnusson, Patrik K.E., Marrugat, Jaume, Nieuwenhuijsen, Mark J., Östenson, Claes-Göran, Pedersen, Nancy L., Pershagen, Göran, Phuleria, Harish C., Probst-Hensch, Nicole M., Raaschou-Nielsen, Ole, Schaffner, Emmanuel, Schikowski, Tamara, Schindler, Christian, Schwarze, Per E., Søgaard, Anne J., Sugiri, Dorothea, Swart, Wim J.R., Tsai, Ming-Yi, Turunen, Anu W., Vineis, Paolo, Peters, Annette, Hoffmann, Barbara
    Publicado 2014
    “…Citation: Fuks KB, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, Oftedal B, Oudin A, Panasevich S, Penell J, Sommar JN, Sørensen M, Tittanen P, Wolf K, Xun WW, Aguilera I, Basagaña X, Beelen R, Bots ML, Brunekreef B, Bueno-de-Mesquita HB, Caracciolo B, Cirach M, de Faire U, de Nazelle A, Eeftens M, Elosua R, Erbel R, Forsberg B, Fratiglioni L, Gaspoz JM, Hilding A, Jula A, Korek M, Krämer U, Künzli N, Lanki T, Leander K, Magnusson PK, Marrugat J, Nieuwenhuijsen MJ, Östenson CG, Pedersen NL, Pershagen G, Phuleria HC, Probst-Hensch NM, Raaschou-Nielsen O, Schaffner E, Schikowski T, Schindler C, Schwarze PE, Søgaard AJ, Sugiri D, Swart WJ, Tsai MY, Turunen AW, Vineis P, Peters A, Hoffmann B. 2014. …”
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    Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)
  7. 113087
    por Dykshoorn, Kristy L.
    Publicado 2014
    “…Obsessive–compulsive disorder (OCD) is a highly researched and conceptualized disorder, and yet it remains one of the most debilitating, widespread, and expensive disorders one can be afflicted with [Real, E., Labad, J., Alonso, P., Segalas, C., Jimenez-Murcia, S., Bueno, B., … Menchon, J. M. (2011). Stressful life events at onset of obsessive–compulsive disorder are associated with a distinct clinical pattern. …”
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    Trauma-related obsessive–compulsive disorder: a review
  8. 113088
    por Kim, Justin, Movassaghi, Mohammad
    Publicado 2015
    “…A cyclo-dipeptide consisting of an essential tryptophan residue and a highly variable ancillary amino acid lies at the core of these structures; investigation of the transformations that take this simplistic core to the complex alkaloids lies at the heart of our research program. …”
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    Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids
  9. 113089
    por Beelen, Rob, Hoek, Gerard, Raaschou-Nielsen, Ole, Stafoggia, Massimo, Andersen, Zorana Jovanovic, Weinmayr, Gudrun, Hoffmann, Barbara, Wolf, Kathrin, Samoli, Evangelia, Fischer, Paul H., Nieuwenhuijsen, Mark J., Xun, Wei W., Katsouyanni, Klea, Dimakopoulou, Konstantina, Marcon, Alessandro, Vartiainen, Erkki, Lanki, Timo, Yli-Tuomi, Tarja, Oftedal, Bente, Schwarze, Per E., Nafstad, Per, De Faire, Ulf, Pedersen, Nancy L., Östenson, Claes-Göran, Fratiglioni, Laura, Penell, Johanna, Korek, Michal, Pershagen, Göran, Eriksen, Kirsten Thorup, Overvad, Kim, Sørensen, Mette, Eeftens, Marloes, Peeters, Petra H., Meliefste, Kees, Wang, Meng, Bueno-de-Mesquita, H. Bas, Sugiri, Dorothea, Krämer, Ursula, Heinrich, Joachim, de Hoogh, Kees, Key, Timothy, Peters, Annette, Hampel, Regina, Concin, Hans, Nagel, Gabriele, Jaensch, Andrea, Ineichen, Alex, Tsai, Ming-Yi, Schaffner, Emmanuel, Probst-Hensch, Nicole M., Schindler, Christian, Ragettli, Martina S., Vilier, Alice, Clavel-Chapelon, Françoise, Declercq, Christophe, Ricceri, Fulvio, Sacerdote, Carlotta, Galassi, Claudia, Migliore, Enrica, Ranzi, Andrea, Cesaroni, Giulia, Badaloni, Chiara, Forastiere, Francesco, Katsoulis, Michail, Trichopoulou, Antonia, Keuken, Menno, Jedynska, Aleksandra, Kooter, Ingeborg M., Kukkonen, Jaakko, Sokhi, Ranjeet S., Vineis, Paolo, Brunekreef, Bert
    Publicado 2015
    “…CITATION: Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer PH, Nieuwenhuijsen MJ, Xun WW, Katsouyanni K, Dimakopoulou K, Marcon A, Vartiainen E, Lanki T, Yli-Tuomi T, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Östenson C-G, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Sørensen M, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita HB, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Jaensch A, Ineichen A, Tsai MY, Schaffner E, Probst-Hensch NM, Schindler C, Ragettli MS, Vilier A, Clavel-Chapelon F, Declercq C, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Vineis P, Brunekreef B. 2015. …”
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    Natural-Cause Mortality and Long-Term Exposure to Particle Components: An Analysis of 19 European Cohorts within the Multi-Center ESCAPE Project
  10. 113090
    “…BACKGROUND: 6-[Bis(carboxymethyl)amino]-1,4-bis(carboxymethyl)-6-methyl-1,4-diazepane (AAZTA ) is a promising chelator with potential advantages over 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) for radiopharmaceutical applications. …”
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    Influence of a novel, versatile bifunctional chelator on theranostic properties of a minigastrin analogue
  11. 113091
    “…The neuronal nitric oxide synthase inhibitor AAAN (N‐(4S)‐4‐amino‐5‐[aminoethyl]aminopentyl‐N′‐nitroguanidine; 10 μmol l(−1), n = 6) or soluble guanylate cyclase (sGC) inhibitor ODQ (1H‐[1,2,4]oxadiazolo[4,3‐a]quinoxalin‐1‐one; 10 μmol l(−1), n = 6) prevented the rise in VFT with CCh. …”
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    Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide
  12. 113092
    “…Using a genetic screening approach, we selected EMCV mutants with single amino acid substitutions in 3A, which rescued RNA virus replication upon small interfering RNA (siRNA) knockdown or pharmacological inhibition of PI4KA. …”
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    Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein
  13. 113093
    por Das, Mousumi, Mandal, Suman Kalyan
    Publicado 2014
    “…The most required essential amino acids and fatty acids were also present in sufficient amount. …”
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    Oxya hyla hyla (Orthoptera: Acrididae) as an Alternative Protein Source for Japanese Quail
  14. 113094
    “…Glucose is the major substrate for ATP synthesis through glycolysis and oxidative phosphorylation (OXPHOS), whereas intermediary metabolism through the tricarboxylic acid (TCA) cycle utilizes non-glucose-derived monocarboxylates, amino acids, and alpha ketoacids to support mitochondrial ATP and GTP synthesis. …”
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    The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases
  15. 113095
    “…RESULTS: Nine SNPs were identified in FASN, among which SNP rs41919985 was predicted to result in an amino acid substitution from threonine (ACC) to alanine (GCC), five SNPs (rs136947640, rs134340637, rs41919992, rs41919984 and rs41919986) were synonymous mutations, and the remaining three (rs41919999, rs132865003 and rs133498277) were found in FASN introns. …”
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    Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association study
  16. 113096
    “…We designed and synthesized three peptides, DOTA-PEG(2)-Nle-CycMSH(hex) (CCZ01047), DOTA-4-amino-(1-carboxymethyl) piperidine (Pip)-Nle-CycMSH(hex) (CCZ01048), and DOTA-Pip-Pip-Nle-CycMSH(hex) (CCZ01056). …”
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    Preclinical Melanoma Imaging with (68)Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET
  17. 113097
    “…Abbreviations used: ABTS: 2,2’-Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic Acid, AE: Aqueous Extract, ANOVA: Analysis Of Variance, AUC: Area Under Curve, BrdU: 5-Bromo-2’-Deoxyuridine, DPPH: 2,2-Diphenyl -1-Pycriylhydrazyl, ELISA: Enzyme Linked Immunosorbent Assay, GLP1: Glucagon Like Peptide 1, GSIS: Glucose Stimulated Insulin Secretion, HPLC-MS: High Performance Liquid Chromatography –Mass Spectrometry, IC50: 50% Inhibitory Concentration, KRH: Krebs/Ringer/Hepes, MTT: 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide, OGTT: Oral Glucose Tolerance Test, ORAC: Oxygen Radical Antioxidant Capacity, OSTT: Oral Starch Tolerance Test, PL: Pancreatic Lipase, SEM: Standard Error Of The Mean, SRB: Sulforhodamine B, TEAC: Trolox Equivalent Antioxidant Capacity, TLC: Thin Layer Chromatography…”
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    Phytochemical and Biological Evaluations of Arum hygrophilum Boiss. (Araceae)
  18. 113098
    “…Thus, one variant with the highest thermostability, AoXyn11A(G21I), was selected from the mutagenesis library, E. coli/Aoxyn11A (G21X) (X: any one of 20 amino acids). Secondly, based on the primary structure multiple alignment of AoXyn11A with seven thermophilic GHF11 xylanases, AoXyn11A(Y13F) or AoXyn11A(G21I–Y13F), was designed by replacing Tyr(13) in AoXyn11A or AoXyn11A(G21I) with Phe. …”
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    Improving the temperature characteristics and catalytic efficiency of a mesophilic xylanase from Aspergillus oryzae, AoXyn11A, by iterative mutagenesis based on in silico design
  19. 113099
    “…The effects of other anti-HIV drugs (nevirapine (NVP) and tenofovirdisoproxil (TDF)), and hydrogen peroxide (H(2)O(2)) were also tested. Amino acid analysis and fatty aldehyde dehydrogenase (ALDH3A2) expression after MMAB expression knock-down with shRNA was used to investigate the metabolic effect of MMAB in Huh-7 cells. …”
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    Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz
  20. 113100
    “…To put this in context, there are 10(13) ways of arranging the 21 proteinogenic amino acids in chains up to 10 units long. Given that we know that a number of these compounds have potent biological activity, it would be highly desirable to be able to search them all to identify leads for new drug molecules. …”
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    The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery
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