“…Distinct metabolic differences were observed between IDH1/2 WT, IDH1R132 and IDH2R140 patients that comprised 22 plasma metabolites that were mainly amino acids. Only two plasma metabolites were statistically significantly different (p < 0.0001) between both IDH1R132 and WT IDH1/2 and IDH2R140 and WT IDH1/2, specifically (2R)-hydroxyglutaric acid (2R-HG) and the threonine metabolite (2R,3S)-dihydroxybutanoic acid (2,3-DHBA). …”
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“…Four-ion R (4) (4)(12) aggregates are also found in the 2-methyl­benzoate, 4-amino­benzoate and 4-nitro­benzoate salts, C(11)H(17)N(2)O(+)·C(8)H(7)O(2) (−) (VIII), C(11)H(17)N(2)O(+)·C(7)H(6)NO(2) (−) (IX) and C(11)H(17)N(2)O(+)·C(7)H(4)NO(4) (−) (X), but those in (IX) are linked into complex sheets by an additional N—H⋯O hydrogen bond. …”
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“…Biomarkers of insulin resistance made the largest contribution to lower risk (accounting for 65.5% of the MED–type 2 diabetes association), followed by BMI (55.5%), high-density lipoprotein measures (53.0%), and inflammation (52.5%), with lesser contributions from branched-chain amino acids (34.5%), very low-density lipoprotein measures (32.0%), low-density lipoprotein measures (31.0%), blood pressure (29.0%), and apolipoproteins (23.5%), and minimal contribution (≤2%) from hemoglobin A(1c). …”
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“…These results will have implications for the development of dietary strategies to improve growth and overall health in pigs, including adjustments to dietary fibre, protein, and amino acid content that maximize pig growth, nutrient utilization, and intestinal health. …”
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“…This elevated glucose demand is partially met by increasing the conversion of glucogenic amino acids (AA) in the liver. Propylene glycol (PG) is a glucogenic precursor and was not tested in dairy goats under thermoneutral (TN) and heat stress (HS) conditions simultaneously. …”
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“…The highest protein level was noted in the seeds of Slovak origin (average 358 g kg(−1)), whereas the lowest protein level (324 g kg(−1)) was determined in the Russian and German lines. Vetch grain fat was rich in linoleic (53%) and linolenic (14%) acids. …”
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“…We next explored the mechanism underlying FOXC1 modulating the metabolism and ROS hemostasis in HCC. METHODS: We used amino acids arrays to verify which metabolism is involved in FOXC1-induced HCC. …”
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“…Glucans are a major nutrient source found in fungi, and β-linked glucans from fungi can be hydrolyzed by β-glucanases from the glycoside hydrolase family 16 (GH16). …”
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“…RESULTS: Analysis of IncI1 plasmids from whole genome sequencing of isolates implicated a gene coding for a 1273 amino acid protein present only in U307 isolates as the likely source of change of phage type. …”
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“…The NC diet was the PC diet but reduced in net energy (NE), digestible amino acids (dig. AA), digestible P (dig. P), and Ca by 74 kcal/kg, 7.0%, 0.134, and 0.119 percentage points, respectively. …”
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“…The open reading frames (ORFs) of GpTre1 and GpTre2 were 1,704 bp and 1,869 bp, which encoded 567 and 622 amino acid residues, respectively. Both of GpTre1 and GpTre2 were mainly expressed in the head and midgut. …”
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“…AMH is secreted as a full-length protein and undergoes proteolytic cleavage at amino acid 451 to become biologically active. Additional proteolytic processing takes place at aa229. …”
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“…Androgen Insensitivity Syndrome (AIS) is an X-linked genetic disease and it is the most common cause of 46,XY DSD. …”
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“…Sequence analysis of the phaA(A–04), phaB(A–04), and phaC(A–04) genes revealed that phaC(A–04) was 99% similar to phaC(H16) from C. necator H16. The difference in amino acid residue situated at position 122 of phaC(A–04) was proline, whereas that of C. necator H16 was leucine. …”
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“…After ensiling, the condensed tannin content for RY18 silages was higher than the control, but non-protein nitrogen, peptide nitrogen, and free amino acid nitrogen contents was lower, while the fraction B1 (buffer-soluble protein) was not different among all the silages. …”
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“…Three of those 39 patients had neural-IgGs detected (high glutamic acid decarboxylase-65, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-receptor and neural-restricted unclassified antibody), and 36 were seronegative. …”
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“…The heterogeneous palladium catalysts (Pd-AmP-MCF or Pd-AmP-CNC) comprise palladium nanoclusters (1–2 nm) immobilized on amino-functionalized siliceous mesocellular foam (MCF) or on crystalline nanocellulose (CNC), exhibiting high activity, selectivity as well as excellent recycling ability. …”
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“…Overall, the replacement of lysine in SVS-1 with other basic amino acids significantly influenced its binding and internalization into cancer cells, as well as its in vivo pharmacokinetic profile. …”
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“…BACKGROUND: Angiotensin receptor blockers (ARBs), such as telmisartan, have been postulated to treat Covid-19-induced lung inflammation. METHODS: This is a parallel-group, randomized, two-arm, open-label, adaptive, multicenter superiority trial with 1:1 allocation ratio. …”
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“…Fruit extracts showed potent anticancer activity against breast (MCF-7) and colon (HT-29) cancer cell lines (LC(50) 329.36 and 385.17 µg/mL, respectively). …”
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