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981por Chen, Bo, Qin, Chuan, Chen, Man, Yu, Hai-Han, Tao, Ran, Chu, Yun-Hui, Bu, Bi-Tao, Tian, Dai-Shi“…The reduced pro-inflammatory cytokines (interleukin-8 and tumor necrosis factor-α) and marked increased lymphocyte (T and B cell) counts were also observed. …”
Publicado 2021
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982por Abdelnabi, Rana, Foo, Caroline S., Kaptein, Suzanne J.F., Zhang, Xin, Do, Thuc Nguyen Dan, Langendries, Lana, Vangeel, Laura, Breuer, Judith, Pang, Juanita, Williams, Rachel, Vergote, Valentijn, Heylen, Elisabeth, Leyssen, Pieter, Dallmeier, Kai, Coelmont, Lotte, Chatterjee, Arnab K., Mols, Raf, Augustijns, Patrick, De Jonghe, Steven, Jochmans, Dirk, Weynand, Birgit, Neyts, Johan“…FINDINGS: When animals were treated with a combination of suboptimal doses of Molnupiravir and Favipiravir at the time of infection, a marked combined potency at endpoint is observed. Infectious virus titers in the lungs of animals treated with the combination are reduced by ∼5 log10 and infectious virus are no longer detected in the lungs of >60% of treated animals. …”
Publicado 2021
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983por Haveri, Anu, Ekström, Nina, Solastie, Anna, Virta, Camilla, Österlund, Pamela, Isosaari, Elina, Nohynek, Hanna, Palmu, Arto A, Melin, Merit“…Subjects with severe infection had markedly higher IgG and NAb levels and are expected to remain seropositive for longer. …”
Publicado 2021
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984por Wang, Xun, Zhao, Xiaoyu, Song, Jieyu, Wu, Jing, Zhu, Yuqi, Li, Minghui, Cui, Yuchen, Chen, Yanjia, Yang, Lulu, Liu, Jun, Zhu, Huanzhang, Jiang, Shibo, Wang, Pengfei“…Using VSV-based pseudovirus, we found that Omicron variant is markedly resistant to neutralization of sera from convalescents or individuals vaccinated by two doses of inactivated whole-virion vaccines (BBIBP-CorV). …”
Publicado 2022
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985por Ma, David, Hirose, Takayuki, Lassiter, Grace, Sasaki, Hajime, Rosales, Ivy, Coe, Taylor M., Rickert, Charles G., Matheson, Rudy, Colvin, Robert B., Qin, Wenning, Kan, Yinan, Layer, Jacob V., Paragas, Violette B., Stiede, Kathryn, Hall, Katherine C., Youd, Michele E., Queiroz, Luis M., Westlin, William F., Curtis, Michael, Yang, Luhan, Markmann, James F., Kawai, Tatsuo“…Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa (TKO) exhibit markedly reduced binding of human natural antibodies. …”
Publicado 2021
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986por Vaivode, Kristine, Verhovcova, Irina, Skrastina, Dace, Petrovska, Ramona, Kreismane, Madara, Lapse, Daira, Kalnina, Zane, Salmina, Kristine, Rubene, Diana, Pjanova, Dace“…Viral RNA copy numbers and titer of infectious virus in the supernatant of Calu3 cells dropped significantly: p = 0.0296 and p = 0.0286, respectively. …”
Publicado 2022
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987“…Furthermore, the titer of the ecdysone hormone was also markedly reduced (90%) in cyromazine-treated adult ovaries, suggesting that ecdysone signaling was directly related to the decrease in the number of GSCs and CBs. …”
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988por Wheatley, Meagan Alisa, Shamoun, John, Maggi, Ricardo, Breitschwerdt, Edward B, Sommer, Samantha L, Cullen, John M, Stowe, Devorah Marks“…Initial infectious disease testing was mostly negative. Toxoplasma gondii titers were most consistent with prior exposure, although reactivation could not be excluded. …”
Publicado 2023
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989por Del Toro, Francisco J., Aguilar, Emmanuel, Hernández-Walias, Francisco J., Tenllado, Francisco, Chung, Bong-Nam, Canto, Tomas“…In contrast to temperature, infection symptoms remained unaltered for the five viruses at elevated CO(2) levels, but viral titers in leaf disks as a proportion of the total protein content increased in all cases, markedly for CMV, and less so for PVY and the PVX constructs. …”
Publicado 2015
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990“…Highly elevated serum titers of IgG antibodies against Toxoplasma gondii were observed. …”
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991por Kaptein, Suzanne J. F., Jacobs, Sofie, Langendries, Lana, Seldeslachts, Laura, ter Horst, Sebastiaan, Liesenborghs, Laurens, Hens, Bart, Vergote, Valentijn, Heylen, Elisabeth, Barthelemy, Karine, Maas, Elke, De Keyzer, Carolien, Bervoets, Lindsey, Rymenants, Jasper, Van Buyten, Tina, Zhang, Xin, Abdelnabi, Rana, Pang, Juanita, Williams, Rachel, Thibaut, Hendrik Jan, Dallmeier, Kai, Boudewijns, Robbert, Wouters, Jens, Augustijns, Patrick, Verougstraete, Nick, Cawthorne, Christopher, Breuer, Judith, Solas, Caroline, Weynand, Birgit, Annaert, Pieter, Spriet, Isabel, Vande Velde, Greetje, Neyts, Johan, Rocha-Pereira, Joana, Delang, Leen“…However, high doses of favipiravir significantly reduced infectious virus titers in the lungs and markedly improved lung histopathology. …”
Publicado 2020
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992“…EBV antiserum, present in the cloning suspension, was shown to neutralize all extracellular virus. 15 of the 17 clones released EBV as measured by the transformation assay. Titers of infectious virus released by daughter clones paralleled titers of virus in the parent line. …”
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993por Merbl, Yifat, Itzchak, Royi, Vider-Shalit, Tal, Louzoun, Yoram, Quintana, Francisco J., Vadai, Ezra, Eisenbach, Lea, Cohen, Irun R.“…Traditionally, immunology has considered a meaningful antibody response to be marked by large amounts of high-affinity antibodies reactive with the specific inciting antigen; the detection of small amounts of low-affinity antibodies binding to seemingly unrelated antigens has been considered to be beneath the threshold of immunological meaning. …”
Publicado 2009
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994“…RESULTS: Using this system, vector particles were produced to markedly greater titers (>1000-fold) than those obtained previously. …”
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995“…Compared to Ov-infected sera, patients infected with Wb, Ll, Ss, and other conditions had markedly lower geometric mean antibody titers to each of the Ov 4 antigens (P<0.0002 for each antigen). …”
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996“…Neurological symptoms were associated with marked lesions of primary demyelination in the white matter of the central nervous system (CNS), and developing after an incubation time of several weeks to months. …”
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997“…His blood work was consistent with hypothyroidism, showing markedly elevated thyroid-stimulating hormone (TSH), suppressed T3 levels, and positive anti-thyroid peroxidase antibody titers. …”
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998por Deng, Wei, Lv, Qi, Li, Fengdi, Liu, Jiangning, Song, Zhiqi, Qi, Feifei, Wei, Qiang, Yu, Pin, Liu, Mingya, Zhou, Shasha, Zhang, Yaqing, Gao, Hong, Wang, Nan, Jia, Zijing, Gao, Kai, Liu, Jiayi, Xiao, Chong, Shang, Haiquan, Wang, Xiangxi, Bao, Linlin, Qin, Chuan“…The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron. …”
Publicado 2022
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999“…The spleens had about one-tenth as many plaque-forming cells as spleens of adult animals immunized similarly, but the antibody titers were as high as titers for adult animals. Presumably the high titers of these young animals resulted from the high ratio of plaque-forming cells to body weight and blood volume. …”
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1000“…Cortisone, hydrocortisone, corticosterone, and corticotropin did not alter significantly the titers of influenza virus attained in the murine lungs during the first 2 days after infection, but cortisone and hydrocortisone markedly delayed the rate at which virus titers declined during the subsequent 6 days. …”
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