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1021“…However, when such females are injected with the molting hormone β-ecdysone a marked stimulation of this enzyme's activity is observable. …”
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1022“…A West Nile virus titer was positive, and serial brain magnetic resonance imaging scans showed resolving abnormalities that paralleled his neurological examination. …”
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1023“…In humans, chronic inflammation, severe injury, infection and disease can result in changes in steroid hormone titers and delayed onset of puberty; however the pathway by which this occurs remains largely unknown. …”
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1024por Wrobel, Marie, Comio, Emilie, Gay, Valerie, Baroudi, Noureddine, Meyer, Pascal, Chuniaud-Louche, Christine, Hacini, Maya, Pica, Gian Matteo“…Hemostatic studies showed prolonged activated partial thromboplastin time, decreased factor VIII coagulation, and a high factor VIII inhibitor titer; these findings led to a diagnosis of acquired hemophilia A for which he was treated with methylprednisolone and recombinant activated factor VII on admission. …”
Publicado 2016
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1025por Uludag, Gunay, Onal, Sumru, Arf, Serra, Sayman Muslubas, Isil, Selcukbiricik, Fatih, Koc Akbay, Aylin, Molinas Mandel, Nil“…A second course of rituximab was necessary as autoantibody titers showed no change and as new antibodies were noted after treatment with rituximab and cyclophosphamide. …”
Publicado 2016
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1026por Al-Abdulwahhab, Abdulrahman Hamad, Al-Sharydah, Abdulaziz Mohammad, Al-Suhibani, Sari Saleh, Al-Jubran, Saeed Ahmad, Al-Haidey, Ali Khalaf, Al-Hifzi, Abdulkhaliq Ibrahim, Al-Issawi, Wissam“…Subsequently, parasite serology showed a markedly elevated level of Schistosoma antibody titers, and cerebrospinal fluid analysis yielded normal results. …”
Publicado 2018
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1027por Sealy, Joshua E., Yaqub, Tahir, Peacock, Thomas P., Chang, Pengxiang, Ermetal, Burcu, Clements, Anabel, Sadeyen, Jean-Remy, Mehboob, Arslan, Shelton, Holly, Bryant, Juliet E., Daniels, Rod S., McCauley, John W., Iqbal, Munir“…Consequently, current vaccine formulations might not induce adequate protective immunity in poultry, and emergence of isolates with marked avidity for human-like receptors increases the zoonotic risk.…”
Publicado 2019
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1028por Wei, Zhanyong, Burwinkel, Michael, Palissa, Christiane, Ephraim, Eden, Schmidt, Michael F.G.“…However, ZnCl(2) and ZnSO(4) markedly reduced viral titers as well as TGEV RNA and viral protein synthesis when applied during virus penetration and at different time points after viral cell entry. …”
Publicado 2012
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1029por Imre, Gergely, Krähling, Verena, Eichler, Madeleine, Trautmann, Sandra, Ferreirós, Nerea, Aman, M. Javad, Kashanchi, Fatah, Rajalingam, Krishnaraj, Pöhlmann, Stefan, Becker, Stephan, Meyer zu Heringdorf, Dagmar, Pfeilschifter, Josef“…The administration of the SphK1 activator, K6PC-5, or S1P, or the overexpression of SphK1 consistently exhibited striking inhibitory effects in EBOV-GP-driven entry in diverse cell lines. Finally, K6PC-5 markedly reduced the EBOV titer in infected cells and the de novo production of viral proteins. …”
Publicado 2021
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1030por Bowen, John E., Sprouse, Kaitlin R., Walls, Alexandra C., Mazzitelli, Ignacio G., Logue, Jennifer K., Franko, Nicholas M., Ahmed, Kumail, Shariq, Asefa, Cameroni, Elisabetta, Gori, Andrea, Bandera, Alessandra, Posavad, Christine M., Dan, Jennifer M., Zhang, Zeli, Weiskopf, Daniela, Sette, Alessandro, Crotty, Shane, Iqbal, Najeeha Talat, Corti, Davide, Geffner, Jorge, Grifantini, Renata, Chu, Helen Y., Veesler, David“…Although mRNA vaccines induced the greatest magnitude of Omicron BA.1 and BA.2 plasma neutralizing activity, administration of a booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1 and BA.2 across all vaccines evaluated. …”
Publicado 2022
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1031por Bowen, John E., Addetia, Amin, Dang, Ha V., Stewart, Cameron, Brown, Jack T., Sharkey, William K., Sprouse, Kaitlin R., Walls, Alexandra C., Mazzitelli, Ignacio G., Logue, Jennifer K., Franko, Nicholas M., Czudnochowski, Nadine, Powell, Abigail E., Dellota, Exequiel, Ahmed, Kumail, Ansari, Asefa Shariq, Cameroni, Elisabetta, Gori, Andrea, Bandera, Alessandra, Posavad, Christine M., Dan, Jennifer M., Zhang, Zeli, Weiskopf, Daniela, Sette, Alessandro, Crotty, Shane, Iqbal, Najeeha Talat, Corti, Davide, Geffner, Jorge, Snell, Gyorgy, Grifantini, Renata, Chu, Helen Y., Veesler, David“…Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. …”
Publicado 2022
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1032por Chen, William C. W., Gaidukov, Leonid, Lai, Yong, Wu, Ming-Ru, Cao, Jicong, Gutbrod, Michael J., Choi, Gigi C. G., Utomo, Rachel P., Chen, Ying-Chou, Wroblewska, Liliana, Kellis, Manolis, Zhang, Lin, Weiss, Ron, Lu, Timothy K.“…We use these circuits to program the secretion of human monoclonal antibodies and to control T-cell effector function marked by interferon-γ production. Antibody titers and interferon-γ concentrations significantly correlate with synthetic promoter strengths, providing a platform for programming gene expression and cellular function in diverse applications.…”
Publicado 2022
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1033por Künstler, András, Király, Lóránt, Kátay, György, Enyedi, Alexander J, Gullner, Gábor“…We demonstrated that in SA-deficient NahG tobacco the elevation of in planta GSH and GSSG levels either by exogenous GSH or by crossing with glutathione overproducing plants confers enhanced resistance to Tobacco mosaic virus (TMV) manifested as both reduced symptoms (i.e. suppression of hypersensitive-type localized necrosis) and lower virus titers. The beneficial effects of elevated GSH on TMV resistance was markedly stronger in NahG than in Xanthi NN leaves. …”
Publicado 2019
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1034“…In addition, EMB showed signs of lymphocytic endocarditis with infiltrates, marked thickening and fibrosis of the endocardium (Fig. 1). …”
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1035por Boudreau, Carolyn M., Burke, John S., Roederer, Alexander L., Gorman, Matthew J., Mundle, Sophia, Lingwood, Daniel, Delagrave, Simon, Sridhar, Saranya, Ross, Ted M., Kleanthous, Harry, Alter, Galit“…Multivariate analysis reveals the presence of a unique pre-existing Fcγ-receptor-binding antibody profile in individuals that evolved broadly reactive hemagglutination inhibition activity (HAI), marked by the presence of elevated levels of pre-existing FCGR2B-binding antibodies. …”
Publicado 2023
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1036“…Continuous passages in primary human amnion cell cultures of Coxsackie prototype viruses A-9, A-10, A-11, A-13, A-14, A-15, A-18, B-1, B-2, B-4, and B-5 increased the titers, hastened and enhanced cytopathic effect, and in varying degrees caused loss of virulence for newborn mice. …”
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1037por Kisand, Kai, Link, Maire, Wolff, Anette S. B., Meager, Anthony, Tserel, Liina, Org, Tõnis, Murumägi, Astrid, Uibo, Raivo, Willcox, Nick, Trebušak Podkrajšek, Katarina, Battelino, Tadej, Lobell, Anna, Kämpe, Olle, Lima, Kari, Meloni, Antonella, Ergun-Longmire, Berrin, Maclaren, Noel K., Perheentupa, Jaakko, Krohn, Kai J. E., Scott, Hamish S., Husebye, Eystein S., Peterson, Pärt“…Neutralizing autoantibodies to type I, but not type II, interferons (IFNs) are found at high titers in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), a disease caused by AIRE gene mutations that lead to defects in thymic T-cell selection. …”
Publicado 2008
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1038por Hamano, Tadanori, Matsunaga, Akiko, Yamamura, Osamu, Nakamura, Masako, Kawamura, Yasutaka, Higuchi, Itsuro, Kuriyama, Masaru, Nakamoto, Yasunari“…High levels of creatine kinase (97,000 IU/L) and high titer of anti-influenza A virus antibody (H3N2) (320 ×) with negative anti-influenza B virus antibody were observed. …”
Publicado 2017
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1039por Saito, Makoto, Senjo, Hajime, Kanaya, Minoru, Izumiyama, Koh, Mori, Akio, Tanaka, Masanori, Morioka, Masanobu, Ieko, Masahiro“…The factor VIII activity level was reduced to 1.2%, and the factor VIII inhibitor titer was 285.3 BU/mL, a diagnosis of acquired hemophilia A (AHA) was made. …”
Publicado 2018
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1040por Choi, Seok-Jin, Kim, Boram, Lee, Haeng-Jin, Kim, Seong-Joon, Kim, Sung-Min, Sung, Jung-Joon“…He began treatment with rituximab, which reduced the rate of relapse markedly. Following discontinuation of rituximab, however, the patient experienced two successive optic neuritis attacks 2 and 4 months after B-lymphocyte restoration. …”
Publicado 2018
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