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1041“…However, it turned out that the term “nanoparticle-enhanced cultivation” could not be used in the context of lovastatin production, as no marked increase of product titer was observed in nanoparticle-influenced variants relative to standard and microparticle-enhanced cultivation. …”
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1042“…By reconstitution experiments, using bovine brain gangliosides as artificial receptors, the degree of super-infection was markedly increased. Analysis of cellular receptor expression revealed reduced concentrations of sialoglycoproteins in general and a limited presentation of the major receptor gp40. …”
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1043por Li, Wenmiao, Xu, Cuijing, Hao, Cui, Zhang, Yang, Wang, Zhaoqi, Wang, Shuyao, Wang, Wei“…Most importantly, intraperitoneal therapy of myricetin markedly improved mice survival and reduced virus titers in both lungs and spinal cord. …”
Publicado 2020
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1044por Sunil Kumar, K.N., Dayanand Reddy, G., Mundugaru, Ravi, Rajagopal, Rajakrishnan, Alfarhan, Ahmed, Kim, Young Ock, Na, Sae Won, Kim, Hak-Jae“…H. elasticus extracts possess marked antibody formation propensity without significant modification on cell mediated immunity.…”
Publicado 2020
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1045por Fan, Sanling, Wu, Yulun, Wang, Hongling, Shang, Yu, Luo, Qingping, Zhang, Tengfei, Zhang, Rongrong, Zhang, Wenting, Luo, Ling, Shao, Huabin, Wen, Guoyuan“…This vaccine was safe in commercial chickens and provided at least 80% protection against a virulent NDV challenge for 3 mo, despite inducing a low hemagglutinin-inhibition titer. For commercial chickens, the protective efficacy of the in-ovo vaccination was markedly higher than that of posthatch vaccination, and the cellular immune response might play an important role in the higher protective efficacy of the in-ovo vaccine. …”
Publicado 2020
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1046por In Yun, Young, Kim, Ji Hyun, Lim, Seon Hee, Ahn, Yo Han, Kang, Hee Gyung, Ha, Il-Soo, Oh, Baek-Lok“…Systemic examination revealed she had acute kidney injury with thrombotic microangiopathy (TMA), multiple cerebral infarcts, valvular dysfunction, and a high titer of triple aPL. Thus, she was diagnosed with CAPS involving the brain, eyes, heart, and kidneys. …”
Publicado 2020
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1047por Woolsey, Courtney, Borisevich, Viktoriya, Prasad, Abhishek N., Agans, Krystle N., Deer, Daniel J., Dobias, Natalie S., Heymann, John C., Foster, Stephanie L., Levine, Corri B., Medina, Liana, Melody, Kevin, Geisbert, Joan B., Fenton, Karla A., Geisbert, Thomas W., Cross, Robert W.“…SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days post-exposure. Marked inflammation and coagulopathy in blood and tissues were prominent features. …”
Publicado 2020
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1048por Nambulli, Sham, Xiang, Yufei, Tilston-Lunel, Natasha L., Rennick, Linda J., Sang, Zhe, Klimstra, William B., Reed, Douglas S., Crossland, Nicholas A., Shi, Yi, Duprex, W. Paul“…Inhalation treatment quickly reverses animals’ weight loss after infection, decreases lung viral titers by 6 logs leading to drastically mitigated lung pathology, and prevents viral pneumonia. …”
Publicado 2021
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1049por Dashdorj, Naranjargal J., Wirz, Oliver F., Röltgen, Katharina, Haraguchi, Emily, Buzzanco, Anthony S., Sibai, Mamdouh, Wang, Hannah, Miller, Jacob A., Solis, Daniel, Sahoo, Malaya K., Arunachalam, Prabhu S., Lee, Alexandra S., Shah, Mihir M., Liu, James, Byambabaatar, Sumiya, Bat-Ulzii, Purevjargal, Enkhbat, Anir, Batbold, Enkhtuul, Zulkhuu, Delgersaikhan, Ochirsum, Byambasuren, Khurelsukh, Tungalag, Dalantai, Ganbold, Burged, Natsagdorj, Baatarsuren, Uurtsaikh, Ariungerel, Nomin, Oidovsambuu, Odgerel, Bungert, Andreas S., Genden, Zulkhuu, Yagaanbuyant, Dahgwahdorj, Mordorj, Altankhuu, Pulendran, Bali, Chinthrajah, Sharon, Nadeau, Kari C., Jardetzky, Theodore, Wilbur, James L., Wohlstadter, Jacob N., Sigal, George B., Pinsky, Benjamin A., Boyd, Scott D., Dashdorj, Naranbaatar D.“…Individuals who recover from SARS-CoV-2 infection after vaccination achieve high antibody titers in most cases. These data suggest that public health interventions such as vaccine boosting, potentially with more potent vaccine types, may be needed to control COVID-19 in Mongolia and worldwide.…”
Publicado 2021
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1050por Kather, Annika, Holtbernd, Florian, Brunkhorst, Robert, Hasan, Dimah, Markewitz, Robert, Wandinger, Klaus-Peter, Wiesmann, Martin, Schulz, Jörg B., Tauber, Simone C.“…Neurological symptoms and SEZ6L2 titer significantly improved after curative tumor therapy. …”
Publicado 2022
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1051por Wang, Qian, Iketani, Sho, Li, Zhiteng, Liu, Liyuan, Guo, Yicheng, Huang, Yiming, Bowen, Anthony D., Liu, Michael, Wang, Maple, Yu, Jian, Valdez, Riccardo, Lauring, Adam S., Sheng, Zizhang, Wang, Harris H., Gordon, Aubree, Liu, Lihong, Ho, David D.“…Titers against BQ and XBB subvariants were lower by 13- to 81-fold and 66- to 155-fold, respectively, far beyond what had been observed to date. …”
Publicado 2023
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1052por Lin, Yu-Jheng, Wang, Li-Chiu, Tsai, Huey-Pin, Chi, Chia-Yu, Chang, Chih-Peng, Chen, Shun-Hua, Wang, Shih-Min“…The condition may deteriorate to disseminated intravascular coagulopathy with markedly increased liver enzymes, inflammatory cytokines, and chemokines, which significantly induce local and systemic inflammation. …”
Publicado 2023
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1053“…C virus from human stools under the same circumstances was detected for 15 days at room temperature (with marked drop in titer after the 3rd day) and for 21 days at 4° with little loss in titer. …”
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1054por Hammami, Sonia, Bdioui, Fethia, Ouaz, Afef, Loghmari, Hichem, Mahjoub, Sylvia, Saffar, Hamouda“…The main etiologies of exudative ascites were excluded. She had markedly elevated anti-nuclear antibody (ANA) titer of 1/1600 and a significantly elevated titer of antibody to double-stranded DNA (83 IU/mL) with hypo-complementemia (C3 levl was at 67 mg/dL). …”
Publicado 2014
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1055por Blodörn, Krister, Hägglund, Sara, Gavier-Widen, Dolores, Eléouët, Jean-François, Riffault, Sabine, Pringle, John, Taylor, Geraldine, Valarcher, Jean François“…These 5 calves shed high titers of virus and developed severe clinical signs of disease and extensive macroscopic lung lesions (mean+/−SD, 48.3+/−12.0% of lung), with a pulmonary influx of inflammatory cells, characterized by interferon gamma secretion and a marked effect on lung function. …”
Publicado 2015
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1056por Feng, Na, Liu, Yuxiu, Wang, Jianzhong, Xu, Weiwei, Li, Tiansong, Wang, Tiecheng, Wang, Lei, Yu, Yicong, Wang, Hualei, Zhao, Yongkun, Yang, Songtao, Gao, Yuwei, Hu, Guixue, Xia, Xianzhu“…RESULTS: The Monkey-BJ01-DV isolate replicated to the highest titer on Vero cells expressing dog-origin SLAM (10(5.2±0.2) TCID(50)/ml) and monkey-origin SLAM (10(5.4±0.1) TCID(50)/ml), but achieved markedly lower titers on human-origin SLAM cells (10(3.3±0.3) TCID(50)/ml). …”
Publicado 2016
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1057“…Interleukin-2 (IL-2) and IL-6 levels in splenocytes supernatant from control and NAFE-treated rats and following in vitro treatment of splenocytes with NAFE (50–1600 μg/ml) were determined using ELISA kits. RESULTS: Marked to a significant increase in antibody titer by both the methods in NAFE-treated mice and a significant increase in skin thickness in rats after challenge with DNCB, respectively suggested humoral and cell-mediated immunostimulant potential of NAFE. …”
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1058“…Workup during this time revealed M spike on serum electrophoresis with IgM kappa on immunofixation. IgM titers were higher than normal. Initially, she was thought to have monoclonal gammopathy of undetermined significance (MGUS) related neuropathy but further workup showed very high levels of anti-MAG antibody titer. …”
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1059“…She also has positive titer for antinuclear antibody. Thyroid ultrasound revealed a right thyroid nodule. …”
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1060por Nikbakht Brujeni, Gholamreza, Hassanzadeh, Mohammad, Al-Karagoly, Hassan, Tolouei, Tohid, Esmailnejad, Atefeh“…IgY and IgA antibodies showed a significant increase in titers 14 days after the second vaccination and reached a peak on day 35 of age. …”
Publicado 2019
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