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1061“…However, despite the absence of detectable viral titers, approximately 40% of S4R22-infected mice succumbed within 3 weeks, indicating that the enhanced mortality following S4R22 infection was not associated with high viral titers. …”
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1062“…Bovine herpesviruses 1 (BoHV-1) and 5 (BoHV-5) share high genetic and antigenic similarities, but exhibit marked differences in tissue tropism and neurovirulence. …”
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1063por Fontana, Francesco, Alfano, Gaetano, Leonelli, Marco, Cerami, Caterina, Ligabue, Giulia, Spinella, Amelia, Citriniti, Giorgia, Manzini, Carlo Umberto, Ferri, Clodoveo, Cappelli, Gianni“…Belimumab was well tolerated by the patient and resulted in a rapid and marked improvement in clinical symptoms and reduction in proteinuria, serum complement levels and anti-dsDNA titer; of note, the patient developed no infectious complications. …”
Publicado 2018
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1064por Xu, Liying, Chen, Junfa, Zhou, Xiajuan, Wu, Lijuan, Tong, Yixin, Zhu, Ni, Huang, Xiaomin, Zhang, Zhuoyi“…The reaction time in thrombography was prolonged (35.8 min; normal range: 5–10 min), coagulation FVIII had markedly decreased activity (12.6%; normal range, 60–150%), and FVIII inhibitor had a high titer [7.4 Bethesda units (BU)/ml; normal range, 0–0.6 BU/ml]. …”
Publicado 2019
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1065“…Furthermore, at baseline, responders demonstrated marked differences in diluted TSAb titers compared with nonresponders (P < 0.001). …”
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1066por Puraswani, Mamta, Khandelwal, Priyanka, Saini, Himanshi, Saini, Savita, Gurjar, Bahadur Singh, Sinha, Aditi, Shende, Rajashri Pramod, Maiti, Tushar Kanti, Singh, Abhishek Kumar, Kanga, Uma, Ali, Uma, Agarwal, Indira, Anand, Kanav, Prasad, Narayan, Rajendran, Padmaraj, Sinha, Rajiv, Vasudevan, Anil, Saxena, Anita, Agarwal, Sanjay, Hari, Pankaj, Sahu, Arvind, Rath, Satyajit, Bagga, Arvind“…Results: Patients presented with markedly elevated anti-FH titers (10,633.2 ± 998.5 AU/ml). …”
Publicado 2019
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1067por Yan, Han, Wang, Jie, Yang, Jiayi, Xu, Zhongqiu, Li, Chunxia, Hao, Cui, Wang, Shixin, Wang, Wei“…The results showed that PSSD had marked anti-HSV-2 activities in vitro with low cytotoxicity. …”
Publicado 2023
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1068por Kikuchi, Chika, Antonopoulos, Aristotelis, Wang, Shengyang, Maemura, Tadashi, Karamanska, Rositsa, Lee, Chiara, Thompson, Andrew J., Dell, Anne, Kawaoka, Yoshihiro, Haslam, Stuart M., Paulson, James C.“…Of these, SIAT-NExt cells exhibit markedly increased binding of H3 HAs and susceptibility to infection by recent H3N2 virus strains, but without impacting final virus titers. …”
Publicado 2023
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1069“…Virus was stable in milk maintained under refrigeration conditions; however, there was a marked reduction in virus titer after incubation at room temperature. …”
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1070por Wang, Wei, Wu, Jiandong, Zhang, Xiaoshuang, Hao, Cui, Zhao, Xiaoliang, Jiao, Guangling, Shan, Xindi, Tai, Wenjing, Yu, Guangli“…Moreover, intranasal administration of KW markedly improved survival and decreased viral titers in IAV-infected mice. …”
Publicado 2017
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1071por Chi, Hang, Zheng, Xuexing, Wang, Xiwen, Wang, Chong, Wang, Hualei, Gai, Weiwei, Perlman, Stanley, Yang, Songtao, Zhao, Jincun, Xia, Xianzhu“…With three immunizations, high titers of neutralizing antibodies (up to 1: 10(4)) were generated without adjuvant. …”
Publicado 2017
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1072por Skrabl-Baumgartner, Andrea, Plecko, Barbara, Schmidt, Wolfgang M., König, Nadja, Hershfield, Michael, Gruber-Sedlmayr, Ursula, Lee-Kirsch, Min Ae“…CASE PRESENTATION: We describe two siblings with early-onset recurrent strokes, arthritis, oral ulcers, discoid rash, peripheral vascular occlusive disease and high antinuclear antibody titers. Assessment of interferon signatures in blood revealed constitutive type I interferon activation. …”
Publicado 2017
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1073“…Lupus anticoagulants (LAC), anticardiolipin (aCL) antibodies and anti-β(2)-glycoprotein-1 (β(2)GPI) titers were all markedly elevated. This case report shows that recurrent episodes of thrombosis can occur despite seemingly adequate anticoagulation in patients with CAPS.…”
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1074por Sweed, Dina, El Shanshory, Mohamed Ramadan, Elaskary, Eman Mohammed, Hassan, Hassnaa Atef, Sweed, Enas, Sweed, Eman, Abdelsattar, Shimaa, Abdelgawad, Ahmed, Mosbeh, Asmaa, Abdallah, Heba, El-Mashad, Shereen, Ehsan, Nermine“…Later, liver affection has also been reported in the form of marked elevated liver enzymes. However, the association of coronavirus disease-19 (COVID-19) and autoimmune diseases is not clear. …”
Publicado 2021
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1075por Koritala, Thoyaja, Mene-Afejuku, Tuoyo O, Schaefer, Matthew, Dondapati, Lavanya, Pleshkova, Yelena, Yasmin, Farah, Mushtaq, Hisham Ahmed, Khedr, Anwar, Adhikari, Ramesh, Al Mutair, Abbas, Alhumaid, Saad, Rabaan, Ali A, Al-Tawfiq, Jaffar A, Jain, Nitesh K, Khan, Syed Anjum, Kashyap, Rahul, Surani, Salim“…Workup revealed high titers of C-ANCA, C-reactive protein, procalcitonin, CT chest evidence of mass-like consolidation, and bronchoscopy findings of friable tissue that was not amenable for biopsy. …”
Publicado 2021
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1076por Boudewijns, Robbert, Pérez, Patricia, Lázaro-Frías, Adrián, Van Looveren, Dominique, Vercruysse, Thomas, Thibaut, Hendrik Jan, Weynand, Birgit, Coelmont, Lotte, Neyts, Johan, Astorgano, David, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Dallmeier, Kai, Esteban, Mariano, García-Arriaza, Juan“…Immunization with one or two doses of MVA-S elicited high titers of S- and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against parental SARS-CoV-2 and VoC alpha, beta, gamma, delta, and omicron. …”
Publicado 2022
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1077por Liu, Dong-qun, Lu, Shuai, Zhang, Lun, Zhang, Ling-xiao, Ji, Mei, Liu, Xiao-Ge, Yu, Zhuo, Liu, Rui-tian“…Moreover, the YSL vaccine elicited an extremely high antibody titer and strong antigen-specific cytotoxic T lymphocyte together with mixed Th1/Th17 cellular immune responses and induced marked prophylactic and therapeutic effects against E.G7-OVA tumors in mouse models. …”
Publicado 2020
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1078por Kaplonek, Paulina, Cizmeci, Deniz, Lee, Jessica Shih-Lu, Shin, Sally A., Fischinger, Stephanie, Gobeil, Philipe, Pillet, Stéphane, Charland, Nathalie, Ward, Brian J., Alter, Galit“…AS03-adjuvanted CoVLP induced robust and durable SARS-CoV-2 specific humoral immunity, marked by strong IgG1antibody responses, potent FcγR binding, and antibody effector function. …”
Publicado 2023
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1079por Tanneti, Nikhila S, Patel, Anant K, Tan, Li Hui, Marques, Andrew D, Perera, Ranawaka A.P.M., Sherrill-Mix, Scott, Kelly, Brendan J, Collman, Ronald G, Rodino, Kyle, Lee, Carole, Bushman, Frederic D, Cohen, Noam A, Weiss, Susan R“…The ongoing SARS-CoV-2 pandemic has been marked with emerging viral variants, some of which were designated as variants of concern (VOCs) due to their selection and rapid circulation in the human population. …”
Publicado 2023
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1080“…These changes in slope of titration curves were reflected in significant discrepancies when densitometric titers (HI(50)) of fractions were compared with their titers in pattern tests. …”
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