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  1. 1061
    “…However, despite the absence of detectable viral titers, approximately 40% of S4R22-infected mice succumbed within 3 weeks, indicating that the enhanced mortality following S4R22 infection was not associated with high viral titers. …”
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    Mouse hepatitis virus neurovirulence: evidence of a linkage between S glycoprotein expression and immunopathology
  2. 1062
    “…Bovine herpesviruses 1 (BoHV-1) and 5 (BoHV-5) share high genetic and antigenic similarities, but exhibit marked differences in tissue tropism and neurovirulence. …”
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    Sequence analysis of the 5′ third of glycoprotein C gene of South American bovine herpesviruses 1 and 5
  3. 1063
    “…Belimumab was well tolerated by the patient and resulted in a rapid and marked improvement in clinical symptoms and reduction in proteinuria, serum complement levels and anti-dsDNA titer; of note, the patient developed no infectious complications. …”
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    Efficacy of Belimumab for active lupus nephritis in a young Hispanic woman intolerant to standard treatment: a case report
  4. 1064
    “…The reaction time in thrombography was prolonged (35.8 min; normal range: 5–10 min), coagulation FVIII had markedly decreased activity (12.6%; normal range, 60–150%), and FVIII inhibitor had a high titer [7.4 Bethesda units (BU)/ml; normal range, 0–0.6 BU/ml]. …”
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    Acquired hemophilia A presenting as progressive intra-abdominal hemorrhage, muscle hemorrhage and hemothorax postpartum: A case report and literature review
  5. 1065
    “…Furthermore, at baseline, responders demonstrated marked differences in diluted TSAb titers compared with nonresponders (P < 0.001). …”
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    Prospective Trial of Functional Thyrotropin Receptor Antibodies in Graves Disease
  6. 1066
    “…Results: Patients presented with markedly elevated anti-FH titers (10,633.2 ± 998.5 AU/ml). …”
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    Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database
  7. 1067
    “…The results showed that PSSD had marked anti-HSV-2 activities in vitro with low cytotoxicity. …”
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    Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
  8. 1068
    “…Of these, SIAT-NExt cells exhibit markedly increased binding of H3 HAs and susceptibility to infection by recent H3N2 virus strains, but without impacting final virus titers. …”
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    Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines
  9. 1069
    “…Virus was stable in milk maintained under refrigeration conditions; however, there was a marked reduction in virus titer after incubation at room temperature. …”
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    Stability of a Tick-Borne Flavivirus in Milk
  10. 1070
    “…Moreover, intranasal administration of KW markedly improved survival and decreased viral titers in IAV-infected mice. …”
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    Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway
  11. 1071
    “…With three immunizations, high titers of neutralizing antibodies (up to 1: 10(4)) were generated without adjuvant. …”
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    DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice
  12. 1072
    “…CASE PRESENTATION: We describe two siblings with early-onset recurrent strokes, arthritis, oral ulcers, discoid rash, peripheral vascular occlusive disease and high antinuclear antibody titers. Assessment of interferon signatures in blood revealed constitutive type I interferon activation. …”
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    Autoimmune phenotype with type I interferon signature in two brothers with ADA2 deficiency carrying a novel CECR1 mutation
  13. 1073
    “…Lupus anticoagulants (LAC), anticardiolipin (aCL) antibodies and anti-β(2)-glycoprotein-1 (β(2)GPI) titers were all markedly elevated. This case report shows that recurrent episodes of thrombosis can occur despite seemingly adequate anticoagulation in patients with CAPS.…”
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    Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation
  14. 1074
    “…Later, liver affection has also been reported in the form of marked elevated liver enzymes. However, the association of coronavirus disease-19 (COVID-19) and autoimmune diseases is not clear. …”
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    Trichrome-positive intrahepatic cytoplasmic globules are potential histopathological clue for COVID-19-induced hepatitis: a case report
  15. 1075
    “…Workup revealed high titers of C-ANCA, C-reactive protein, procalcitonin, CT chest evidence of mass-like consolidation, and bronchoscopy findings of friable tissue that was not amenable for biopsy. …”
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    Granulomatous Polyangiitis With Renal Involvement: A Case Report and Review of Literature
  16. 1076
    “…Immunization with one or two doses of MVA-S elicited high titers of S- and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against parental SARS-CoV-2 and VoC alpha, beta, gamma, delta, and omicron. …”
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    MVA-CoV2-S Vaccine Candidate Neutralizes Distinct Variants of Concern and Protects Against SARS-CoV-2 Infection in Hamsters
  17. 1077
    “…Moreover, the YSL vaccine elicited an extremely high antibody titer and strong antigen-specific cytotoxic T lymphocyte together with mixed Th1/Th17 cellular immune responses and induced marked prophylactic and therapeutic effects against E.G7-OVA tumors in mouse models. …”
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    A biomimetic yeast shell vaccine coated with layered double hydroxides induces a robust humoral and cellular immune response against tumors
  18. 1078
    “…AS03-adjuvanted CoVLP induced robust and durable SARS-CoV-2 specific humoral immunity, marked by strong IgG1antibody responses, potent FcγR binding, and antibody effector function. …”
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    Robust induction of functional humoral response by a plant-derived Coronavirus-like particle vaccine candidate for COVID-19
  19. 1079
    “…The ongoing SARS-CoV-2 pandemic has been marked with emerging viral variants, some of which were designated as variants of concern (VOCs) due to their selection and rapid circulation in the human population. …”
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    Comparison of SARS-CoV-2 variants in primary human nasal cultures indicates Delta as most cytopathic and Omicron as fastest replicating
  20. 1080
    “…These changes in slope of titration curves were reflected in significant discrepancies when densitometric titers (HI(50)) of fractions were compared with their titers in pattern tests. …”
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    INFLUENZA VIRUS AND ITS MUCOPROTEIN SUBSTRATE IN THE CHORIOALLANTOIC MEMBRANE OF THE CHICK EMBRYO : I. CHARACTERIZATION AND QUANTITATIVE ASSAY OF SUBSTRATE AND STUDIES ON ITS RELATION TO ALLANTOIC CELLS
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