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1081por Diallo, Aldiouma, Sow, Samba O., Idoko, Olubukola T., Hirve, Siddhivinayak, Findlow, Helen, Preziosi, Marie-Pierre, Elie, Cheryl, Kulkarni, Prasad S., Parulekar, Varsha, Diarra, Bou, Cheick Haidara, Fadima, Diallo, Fatoumata, Tapia, Milagritos, Akinsola, Adebayo K., Adegbola, Richard A., Bavdekar, Ashish, Juvekar, Sanjay, Chaumont, Julie, Martellet, Lionel, Marchetti, Elisa, LaForce, Marc F., Plikaytis, Brian D., Enwere, Godwin C., Tang, Yuxiao, Borrow, Ray, Carlone, George, Viviani, Simonetta“…In both studies, substantial SBA decay was observed at 6 months postvaccination in both vaccine groups, although more marked in the PsACWY group. At 1 year and 4 years (only for study A) postvaccination, SBA titers were relatively sustained in the PsA-TT group, whereas a slight increasing trend, more pronounced among the youngest, was observed in the participants aged <18 years in the PsACWY groups. …”
Publicado 2015
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1082“…AJSAF also markedly promoted Con A-, LPS- and H9–Ag-stimulated splenocyte proliferation and natural killer cell activity. …”
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1083“…In myasthenia gravis with predominantly IgG4 autoantibodies against muscle-specific kinase (MuSK), it has been observed that one-time CD20(+) B cell depletion with rituximab commonly leads to long-term remission and a marked reduction in autoantibody titer, pointing to a short-lived nature of autoantibody-secreting cells. …”
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1084por Pan, Tian-Xu, Huang, Hai-Bin, Zhang, Jia-Lin, Li, Jun-Yi, Li, Ming-Han, Zhao, Dong-Yu, Li, Yan-Ning, Zheng, Wei, Ma, Rui-Geng, Wang, Nan, Shi, Chun-Wei, Wang, Chun-Feng, Yang, Gui-Lian“…The results of this study demonstrate the effectiveness of recombinant L. plantarum as an immunization agent for chickens. Specific IgA titers in the intestine and specific IgG antibody titers in the serum were significantly higher in chickens immunized with recombinant L. plantarum (P < 0.001). …”
Publicado 2023
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1085por Sheehan, Jared, Ardizzone, Caleb M., Khanna, Mayank, Trauth, Amber J., Hagensee, Michael E., Ramsay, Alistair J.“…RBD- and spike-specific IgG4 antibody levels were markedly elevated in three-dose but not two-dose immune sera. …”
Publicado 2023
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1086“…The antibody response to these vaccines was measured by means of the in vitro agglutination inhibition test, and the geometric mean titers of sera taken 2 weeks after vaccination were compared. …”
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1087Publicado 1989“…Immunized mice had significantly lower lung virus titers than did control mice, and did not possess any neutralizing antibodies to the challenger viruses. …”
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1088por Oestereich, Lisa, Rieger, Toni, Neumann, Melanie, Bernreuther, Christian, Lehmann, Maria, Krasemann, Susanne, Wurr, Stephanie, Emmerich, Petra, de Lamballerie, Xavier, Ölschläger, Stephan, Günther, Stephan“…Clustering of infected hepatocytes in necrotic areas without marked inflammation suggests viral cytopathic effects. …”
Publicado 2014
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1089“…Ex vivo and in vitro studies revealed marked increase in OD and stimulation index indicating MOLE-induced splenocytes proliferation. …”
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1090por Feng, Qian, Hui, Jing, Tang, Na, Liu, Yong-Min, Zhong, Hua, Li, Zhen, Wang, La-Mei, Qu, Yuan-Yuan, Deng, Feng-Mei, He, Fang“…Similarly, elevated TNF-α and 8-OHDG levels were independent predictors of increased HCMV antibody titers, whereas eNOS and renin were negatively correlated with the latter. …”
Publicado 2018
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1091por Sun, Yuhang, Su, Jiarui, Liu, Zixuan, Liu, Dandan, Gan, Fang, Chen, Xingxiang, Huang, Kehe“…In vitro studies demonstrated that low concentrations of AFB(1) (0.01–0.25 μg/ml) markedly promoted SIV replication as revealed by increased viral titers and matrix protein (M) mRNA and nucleoprotein (NP) levels in MDCK cells, A549 cells and PAMs. …”
Publicado 2018
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1092por Nitta, Sayuri, Asahina, Yasuhiro, Kato, Takanobu, Tsuchiya, Jun, Inoue-Shinomiya, Emi, Sato, Ayako, Tsunoda, Tomoyuki, Miyoshi, Masato, Kawai-Kitahata, Fukiko, Murakawa, Miyako, Itsui, Yasuhiro, Nakagawa, Mina, Azuma, Seishin, Kakinuma, Sei, Hikita, Hayato, Takehara, Tetsuo, Watanabe, Mamoru“…Viruses harboring R30Q/A92K showed high extracellular core antigens and infectivity titers, whereas the other viruses with RASs showed low replication levels and infectivity titers. …”
Publicado 2019
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1093por Kato‐Miyashita, Sari, Sakai‐Tagawa, Yuko, Yamashita, Makoto, Iwatsuki‐Horimoto, Kiyoko, Ito, Mutsumi, Tokita, Akifumi, Hagiwara, Haruhisa, Izumida, Naomi, Nishino, Tamon, Wada, Noriyuki, Koga, Michiko, Adachi, Eisuke, Jubishi, Daisuke, Yotsuyanagi, Hiroshi, Kawaoka, Yoshihiro, Imai, Masaki“…Importantly, the variants with the three‐amino‐acid deletion appeared to be antigenically different from the B/Colorado/06/2017 virus with the two‐amino‐acid deletion, the vaccine strain for the 2018‐2019 season with a fourfold or eightfold difference in HI titer. One B/Yamagata‐lineage isolate carrying a G407S mutation in its NA showed a marked reduction in susceptibility to zanamivir, peramivir, and laninamivir. …”
Publicado 2020
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1094por Shrwani, Khalid, Sharma, Ravi, Krishnan, Madhan, Jones, Terry, Mayora-Neto, Martin, Cantoni, Diego, Temperton, Nigel J, Dobson, Susan L, Subramaniam, Krishanthi, McNamara, Paul S, Cunliffe, Nigel A, Turtle, Lance, Zhang, Qibo“…RESULTS: A significant proportion of children (up to 40%) had detectable cross-reactive antibodies to SARS-CoV-2 S1, S1-RBD, and NP antigens, and the anti-S1 and anti–S1-RBD antibody levels correlated with anti–HCoV-HKU1 and anti–HCoV-OC43 S1 antibody titers in prepandemic samples (P < .001). There were marked increases of anti–HCoV-HKU1 and - OC43 S1 (but not anti-NL63 and -229E S1-RBD) antibody titers in serum samples from convalescent COVID-19 patients (P < .001), indicating an activation of cross-reactive immunological memory to β-coronavirus spike. …”
Publicado 2021
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1095por Cheng, Cho-Chin, Platen, Louise, Christa, Catharina, Tellenbach, Myriam, Kappler, Verena, Bester, Romina, Liao, Bo-Hung, Holzmann-Littig, Christopher, Werz, Maia, Schönhals, Emely, Platen, Eva, Eggerer, Peter, Tréguer, Laëtitia, Küchle, Claudius, Schmaderer, Christoph, Heemann, Uwe, Renders, Lutz, Protzer, Ulrike, Braunisch, Matthias Christoph“…Hemodialysis patients are exposed to a markedly increased risk when infected with SARS-CoV-2. …”
Publicado 2022
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1096por Peterhoff, David, Wiegrebe, Simon, Einhauser, Sebastian, Patt, Arisha J., Beileke, Stephanie, Günther, Felix, Steininger, Philipp, Niller, Hans H., Burkhardt, Ralph, Küchenhoff, Helmut, Gefeller, Olaf, Überla, Klaus, Heid, Iris M., Wagner, Ralf“…We found a significant decline of neutralization titers and binding antibody levels in most assays (linear mixed regression model, p<0.01). …”
Publicado 2023
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1097“…Mice treated with anti-γM were immunologically suppressed in all immunoglobulin classes as determined by serum antibody titers, splenic plaque-forming cells, serum immunoglobulin levels, and immunofluorescent analysis of plasma cells in lymphoid tissues. …”
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1098“…When the gene encoding this protein is deleted from the genome, the virus is markedly less virulent when injected into the brains of animal models. …”
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1099por Lin, De-Shun, Yen, Hong-Wei, Kao, Wei-Chen, Cheng, Chieh-Lun, Chen, Wen-Ming, Huang, Chieh-Chen, Chang, Jo-Shu“…CONCLUSIONS: The proposed butyrate addition and VMD in situ butanol removal strategies are very effective in enhancing both butanol titer and butanol yield. This would significantly enhance the economic feasibility of fermentative production of butanol. …”
Publicado 2015
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1100por Lu, Jihu, Wu, Peipei, Zhang, Xuehua, Feng, Lei, Dong, Bin, Chu, Xuan, Liu, Xiufan, Peng, Daxin, Liu, Yuan, Ma, Huailiang, Hou, Jibo, Tang, Yinghua“…Furthermore, cellular immune response was markedly improved in terms of increasing the serum levels of cytokine interferon-γ and interleukine 4, promoting proliferation of splenocytes and upregulating cytotoxicity activity in both H5- and H9-CVCVA5 vaccinated chickens. …”
Publicado 2016
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