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1141“…Importantly, pre-treatment of cells with the nucleoprotein-specific siRNAs markedly reduces the virus titer. The antiviral effect of the siRNAs was not attributable to interferon or the interferon response effector molecule, PKR. …”
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1142por Au, Bryan C., Lee, Chyan-Jang, Lopez-Perez, Orlay, Foltz, Warren, Felizardo, Tania C., Wang, James C.M., Huang, Ju, Fan, Xin, Madden, Melissa, Goldstein, Alyssa, Jaffray, David A., Moloo, Badru, McCart, J. Andrea, Medin, Jeffrey A.“…In both cohorts we observed marked tissue-specific responses as measured by clinical evaluations and magnetic resonance imaging of the prostate gland. …”
Publicado 2016
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1143“…The patient was free from oral analgesics. RA test titer that was 160 international units per milliliter (IU/ml) before treatment showed marked reduction (28.12 IU/ml) after 75 days of treatment and later dropped in normal range (6.1 IU/ml). …”
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1144“…We recently reported studies with solid tumor-derived cell lines demonstrating that radiosensitivity as measured by multiwell plate colorimetric (e.g., XTT) and fluorimetric (e.g., CellTiter-Blue) assays reflects growth arrest but not loss of viability. …”
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1145“…In contrast, fimE transcription was much lower than either fimA or fimB early, increased markedly at 24 h after inoculation, and then dropped five days after inoculation. …”
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1146por Wang, Yaping, Jia, Liangliang, Shen, Jian, Wang, Yidong, Fu, Zurong, Su, Sheng-an, Cai, Zhejun, Wang, Jian-an, Xiang, Meixiang“…Compared with the wild-type mice receiving equal amount of CVB3, genetic ablation of CatB (Ctsb(-/-)) significantly improved survival, reduced inflammatory cell infiltration, decreased serum level of cardiac troponin I, and ameliorated cardiac dysfunction, without altering virus titers in hearts. Conversely, genetic deletion of cystatin C (Cstc(-/-)), which markedly enhanced CatB levels in hearts, distinctly increased the severity of VMC. …”
Publicado 2018
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1147por Kamaguchi, Mayumi, Iwata, Hiroaki, Ujiie, Inkin, Ujiie, Hideyuki, Sato, Jun, Kitagawa, Yoshimasa, Shimizu, Hiroshi“…Erosions in the oral cavity usually result in markedly decreased quality of life. The major autoantigens are BP180 and laminin332, which are components of basement membrane proteins in the skin and mucosa. …”
Publicado 2018
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1148por Suzuki, Naoto, Yoshida, Takeshi, Takeuchi, Hiroaki, Sakuma, Ryuta, Sukegawa, Sayaka, Yamaoka, Shoji“…Collectively, these results indicate that promoter activation in producer cells represents a promising approach to preparing high-titer lentiviral vectors.…”
Publicado 2018
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1149por Xu, Zhichao, Lin, Ying, Zou, Chuangchao, Peng, Peng, Wu, Yanan, Wei, Ying, Liu, Yuan, Gong, Lang, Cao, Yongchang, Xue, Chunyi“…In this study, an original, highly virulent PEAV strain GDS04 was serially passaged in Vero cells. The virus titers and sizes of syncytia increased gradually with the cell passages. …”
Publicado 2019
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1150por Ashton, Laura V., Quackenbush, Sandra L., Castle, Jake, Wilson, Garin, McCoy, Jasmine, Jordan, Mariah, MacNeill, Amy L.“…Virus dissemination in rabbit tissues was similar for MYXVorfC and MYXV. Virus titers recovered from tissues were lower in MYXVorfC-infected rabbits as compared to MYXV-infected rabbits. …”
Publicado 2020
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1151por Sun, Yuhan, Li, Zhi, Liang, Wei, Zhang, Yanlong, Song, Wanli, Song, Jiazhe, Xue, Kai, Wang, Meiling, Sun, Wenying, Gu, Jianguo, Li, Ming, Li, Wenzhe“…In the present study, we found that the level of core fucosylation catalyzed by α1,6-fucosyltransferase (Fut8) is markedly up-regulated on immunoglobulin G (IgG) in the sera of SLE patients detected by Aspergillus oryzae lectin (AOL) blot. …”
Publicado 2020
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1152por Sun, Pureum, Kim, Yeeun, Lee, Hoyoung, Kim, Jihyun, Han, Bok Kyung, Go, Eunbyeol, Kwon, Somin, Kang, Ju-Gyeong, You, Sooseong, Kwon, Jaeyul“…In a mouse model of immunosuppression induced by cyclophosphamide, animals given CPP before and after an influenza vaccine challenge showed increased frequencies of dendritic cells and natural killer cells in the spleen, in addition to the recovery of vaccine-specific antibody titers. Moreover, innate myeloid cells in CPP-fed mice showed evidence of phenotypic modification via markedly enhanced interleukin(IL)-12 and interferon(IFN)-γ production in response to lipopolysaccharide(LPS) stimulation ex vivo. …”
Publicado 2020
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1153por Shaikh, Gulvahid, Gosmanova, Elvira O., Rigual-Soler, Natacha, Der Mesropian, Paul“…Kidney biopsy showed membranoproliferative glomerulonephritis pattern of injury with “full house” pattern on immunofluorescent staining with subendothelial deposits on electron microscopy. Markedly elevated IgG (immunoglobulin G) titers for B henselae and B quintana were discovered. …”
Publicado 2020
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1154por Lee, Hyungdon, Choi, Woo Young, Kim, Choon Mee, Yun, Na-Ra, Kim, Dong-Min, Pyun, Sang-Hyun, Yu, Byung Jun, Lee, You Mi“…However, we confirmed SFTS through PCR and increasing antibody titer. However, his blood culture also indicated E. coli infection. …”
Publicado 2021
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1155por Liu, Mengshuang, Liu, Hui, Shi, Meng, Jiang, Mingyue, Li, Lingling, Zheng, Yanning“…Ectoine was traditionally produced by Halomonas elongata through a “bacterial milking” process, of which the marked feature is using a high-salt medium to stimulate ectoine biosynthesis and then excreting ectoine into a low-salt medium by osmotic shock. …”
Publicado 2021
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1156por Xiao, Yang, Shu, Lingling, Wu, Xiaoping, Liu, Yang, Cheong, Lai Yee, Liao, Boya, Xiao, Xiaoyu, Hoo, Ruby L.C., Zhou, Zhiguang, Xu, Aimin“…Furthermore, the spontaneous development of autoimmune diabetes in NOD mice was markedly reduced by pharmacological inhibition or genetic ablation of FABP4 or adoptive transfer of FABP4-deficient bone marrow cells. …”
Publicado 2021
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1157por Jangra, Sonia, Landers, Jeffrey J., Rathnasinghe, Raveen, O’Konek, Jessica J., Janczak, Katarzyna W., Cascalho, Marilia, Kennedy, Andrew A., Tai, Andrew W., Baker, James R., Schotsaert, Michael, Wong, Pamela T.“…The combination adjuvant with spike protein antigen elicited robust responses to SARS-CoV-2 in mice, with markedly enhanced T(H)1-biased cellular responses and high virus-neutralizing antibody titers towards both homologous SARS-CoV-2 and a variant harboring the N501Y mutation shared by B1.1.7, B.1.351 and P.1 variants. …”
Publicado 2021
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1158por Monel, Blandine, Planas, Delphine, Grzelak, Ludivine, Smith, Nikaïa, Robillard, Nicolas, Staropoli, Isabelle, Goncalves, Pedro, Porrot, Françoise, Guivel-Benhassine, Florence, Guinet, Nathalie Demory, Rodary, Julien, Puech, Julien, Euzen, Victor, Bélec, Laurent, Orvoen, Galdric, Nunes, Léa, Moulin, Véronique, Fourgeaud, Jacques, Wack, Maxime, Imbeaud, Sandrine, Campagne, Pascal, Duffy, Darragh, Santo, James P. Di, Bruel, Timothée, Péré, Hélène, Veyer, David, Schwartz, Olivier“…FINDINGS: With both lineages, viral titers were variable, ranging from 0 to >10(6) infectious units. …”
Publicado 2021
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1159por Ayanful-Torgby, Ruth, Sarpong, Esther, Abagna, Hamza B., Donu, Dickson, Obboh, Evans, Mensah, Benedicta A., Adjah, Joshua, Williamson, Kim C., Amoah, Linda E.“…The high prevalence of children infected with distinct gametocyte clones coupled with marked variation in infection status at the individual level suggests ongoing transmission and should be targeted in malaria control programs.…”
Publicado 2021
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1160por Zhang, Longxiang, Lin, Jihui, Weng, Maoyang, Wen, Ying, Zhang, Yanming, Deng, Wen“…In addition, lentivirus-mediated shRNA knockdown of RPLP1 drastically attenuated CSFV growth, while stable overexpression of RPLP1 markedly enhanced CSFV production. Moreover, cellular RPLP1 expression was found to be significantly up-regulated along with CSFV infection. …”
Publicado 2022
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