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  1. 1181
    “…Admittedly, production titers are very low, and pamamycins are typically formed as crude mixture of mainly smaller derivatives, leaving larger derivatives rather unexplored so far. …”
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    Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2
  2. 1182
    “…Types I and II sera obtained in our experiments with culture sediment and whole culture did not vary markedly for a given type and corresponded closely in their protective titer with samples of sera received from The Rockefeller Institute Hospital. …”
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    A NOTE ON THE PRODUCTION OF ANTIPNEUMOCOCCUS SERA
  3. 1183
    “…Chickens, whose electrophoretic serum pattern is markedly different from that of rabbits, were also immunized against the Japanese B encephalitis virus. …”
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    ELECTROPHORETIC STUDY OF ANTIVIRAL SERA
  4. 1184
    “…All recipients exhibited similar increases in NP-specific antibody titers during primary, secondary, and long-term memory responses. …”
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    B cell–intrinsic TLR signals amplify but are not required for humoral immunity
  5. 1185
    “…Vaccinated goats had higher protective CMI response and also higher antibody titer for the trial period as compared to “Sham immunized”. …”
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    Therapeutic Effects of a New “Indigenous Vaccine” Developed Using Novel Native “Indian Bison Type” Genotype of Mycobacterium avium Subspecies paratuberculosis for the Control of Clinical Johne's Disease in Naturally Infected Goatherds in India
  6. 1186
    “…The NNCC treated groups (2, 3, 5 and 6) showed marked improvement in all the above parameters. It can be concluded that herbal NNCC offered protection and proved beneficial in resisting the adverse effects of stressor.…”
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    Evaluation of Herbal Neonatal Chick Care Against Iron-induced Toxicity in Broilers
  7. 1187
    “…This study investigated the potential of R848 and poly(I:C) as an adjuvant 146S foot-and-mouth disease virus (FMDV) vaccine formulated with aluminum hydroxide (Al(OH)(3)). RESULTS: Antibody titers to FMDV and CD8(+) T cells were markedly enhanced in mice immunized to 146S FMDV + Al(OH)(3) + R848 + poly(I:C) compared with mice immunized to FMDV + ISA206. …”
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    Resiquimod and polyinosinic–polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine
  8. 1188
    “…While no significant E-protein specific humoral response was generated after DNA immunization, protein boosting of DNA-primed mice resulted in a marked increase in total neutralizing antibody titer. …”
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    Vaccination of Mice Using the West Nile Virus E-Protein in a DNA Prime-Protein Boost Strategy Stimulates Cell-Mediated Immunity and Protects Mice against a Lethal Challenge
  9. 1189
    “…After repeated inoculation of the protease-activated receptor 2 knockout mouse with ES proteins, airway inflammation and Th2 immune responses were markedly reduced, but not to basal levels. Furthermore, asthma patients had higher Acanthamoeba-specific IgE titers than healthy controls and we found Acanthamoeba specific antigen from house dust in typical living room. …”
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    Acanthamoeba Protease Activity Promotes Allergic Airway Inflammation via Protease-Activated Receptor 2
  10. 1190
    “…Homologous antisera from field‐vaccinated chickens were markedly immunosuppressive, annulling the efficacy of the vaccine and leaving the chickens as susceptible to infection as non‐vaccinated birds. …”
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    Effect of passive immunization on immunogenicity and protective efficacy of vaccination against a Mexican low‐pathogenic avian H5N2 influenza virus
  11. 1191
    “…Compared to the healthy controls, we found a marked elevation of HS and DS in all of the MPS II-affected patients. …”
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    The levels of urinary glycosaminoglycans of patients with attenuated and severe type of mucopolysaccharidosis II determined by liquid chromatography-tandem mass spectrometry
  12. 1192
    “…Coagulation times were markedly shortened by intravenous FIX in orally tolerized treated dogs, in contrast to control dogs that formed high-titer antibodies to FIX. …”
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    Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce
  13. 1193
    “…Recombinant TolC (rTolC), rLppC, and rHAPS_0926 proteins showing marked protection of mice against H. parasuis infection, and were further evaluated individually or in combination. …”
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    Evaluation of immunogenicity and protective efficacy of recombinant outer membrane proteins of Haemophilus parasuis serovar 5 in a murine model
  14. 1194
    “…The 2009 H1N1 influenza (Pdm09) pandemic has been referred to as the first influenza pandemic of the twenty-first century. There is a marked difference in antigenicity between the pandemic H1N1 virus and past seasonal H1N1 viruses, which allowed the pandemic virus to spread rapidly in humans. …”
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    Comparison of the Protective Efficacy of Neutralizing Epitopes of 2009 Pandemic H1N1 Influenza Hemagglutinin
  15. 1195
    “…The serum acetylcholine receptor (AChR) antibody titer was within reference range. Cerebrospinal fluid analysis was unremarkable. …”
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    Congenital Myasthenic Syndrome in a Mixed Breed Dog
  16. 1196
    “…Typically, leptin deficiency is associated with the Th2 polarization that markedly coincides with the pathogenesis of VL. The aim of the present study was to unravel the prophylactic role of leptin in malnutrition-coupled VL mice. …”
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    Leptin regulates Granzyme-A, PD-1 and CTLA-4 expression in T cell to control visceral leishmaniasis in BALB/c Mice
  17. 1197
    “…The anti-streptolysin O (ASO) titer was elevated (805 kU/l). Antibiotic therapy did not improve his condition. …”
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    Altered cerebral glucose metabolism normalized in a patient with a pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS)-like condition following treatment with plasmapheresis: a case report
  18. 1198
    “…Compound 7e, selected for time of addition experiments on BHK-21 cell cultures infected with YFV, achieved the highest reduction of virus titer when added 2 h post infection and maintained up to 4 h post infection.…”
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    Design, Synthesis, Antiviral Evaluation, and SAR Studies of New 1-(Phenylsulfonyl)-1H-Pyrazol−4-yl-Methylaniline Derivatives
  19. 1199
    “…Engineered OMVs elicited high, saturating antigen-specific antibody titers when administered to mice in quantities as low as 0.2 μg/dose. …”
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    Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for Staphylococcus aureus vaccine
  20. 1200
    “…How SARS-CoV-2 is able to achieve high titer in the absence of symptoms remains unclear. …”
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    Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
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