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  1. 1201
    “…S-2P in combination with CpG 1018 and aluminum hydroxide (alum) was found to be the most potent immunogen and induced high titer of neutralizing antibodies in sera of immunized mice against pseudotyped lentivirus reporter or live wild-type SARS-CoV-2. …”
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    Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19
  2. 1202
    “…Here, we report the case of a 43-year-old man who had marked prolongation of prothrombin time and activated partial thromboplastin time after surgery. …”
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    Development of Acquired Factor V Inhibitor After Surgical Procedure Without the Use of Fibrin Tissue Adhesives: A Case Report
  3. 1203
    “…LAS chickens had significantly higher viral titers in blood and other tissues, as well as oral secretions, and significantly lower development of neutralizing antibody responses compared to HAS chickens. …”
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    Pathogenesis and shedding of Usutu virus in juvenile chickens
  4. 1204
    “…Surprisingly, CP treatment did not predict survival. Strikingly, marked decline in neutralization titers was observed in the fatal patients prior to death, and convalescent plasma treatment did not reverse this trend. …”
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    Impact of Convalescent Plasma Therapy on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Profile in Coronavirus Disease 2019 (COVID-19) Patients
  5. 1205
    “…Inflammatory cytokines were markedly reduced by Ph while a slight decrease was only found for US-FS1.…”
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    Chondroitin Sulfate in USA Dietary Supplements in Comparison to Pharma Grade Products: Analytical Fingerprint and Potential Anti-Inflammatory Effect on Human Osteoartritic Chondrocytes and Synoviocytes
  6. 1206
    “…In all patients, FVIII activity levels were low (median: 1.5%; 1–3%), FVIII inhibitor titers were high (median: 24.5 BU/mL; 13.2–48.6 BU/mL), and activated partial thromboplastin time was markedly prolonged (median: 99.4 s; 60.9–110.1 s). …”
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    Feasibility of therapeutic plasma exchange-based combination therapy in the treatment of acquired hemophilia A: A retrospective 6 case series
  7. 1207
    “…In SLE patients, sCD226 levels were significantly correlated with SLEDAI-2K scores and anti-dsDNA antibody titers. Moreover, the cumulative probability of flare was markedly higher in patients with high sCD226 than in those with low sCD226. …”
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    Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus
  8. 1208
    “…Gas chromatographic analysis showed that cannabinoids remained the predominant class of compounds in both extracts (82.56% and 86.38%, respectively), whereas a marked depletion of the terpenes occurred. Moreover, liquid chromatographic analysis highlighted a high titer of cannabidiol acid (CBDA) and CBD in CFHE1 and CFHE2, respectively. …”
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    Phytochemical characterization and biological properties of two standardized extracts from a non‐psychotropic Cannabis sativa L. cannabidiol (CBD)‐chemotype
  9. 1209
    “…We showed that plasma levels of C1q and circulating immune complexes were markedly increased in patients with severe COVID-19 and correlated with higher immunoglobulin (Ig) G titers, greater complement activation, and higher disease severity score. …”
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    Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019( )
  10. 1210
    “…The outcome in ABOi kidney transplantation have markedly improved over the years. In fact, although randomized trials are still lacking, recent meta analysis has revealed that there is no difference in terms of graft and patient’s survival between ABOi and ABO compatible kidney transplant, even in the long term. …”
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    Current Perspectives in ABO-Incompatible Kidney Transplant
  11. 1211
    “…Therefore, on fresh berries infectious viruses are markedly inactivated over time and can be largely removed by washing with water. …”
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    SARS-CoV-2 remains infectious for at least a month on artificially-contaminated frozen berries
  12. 1212
    “…Here, we report that a high-titer HBV inoculum can be generated from the transient transfection-based cell model after optimizing transfection conditions and modifying the HBV-expressing construct. …”
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    In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolates
  13. 1213
    “…Results indicated that saliva could be a reliable and financially viable option in both testing viral titers as well as marking for bio analytes due to its propitious specificity and sensitivity results reported in most of the studies. …”
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    Saliva as a propitious diagnostic biofluid, biomarker, and bodies first line of defense against COVID-19: A review
  14. 1214
    “…This study has demonstrated that a double immunization enhances the growth of antibody titers as assessed by the microneutralization assay (MNA) and the enzyme-linked immunosorbent assay (ELISA) in a pre-clinical immunogenicity test on animal models. …”
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    Safety and immunogenicity of the first Kazakh inactivated vaccine for COVID-19
  15. 1215
    Publicado 1993
    “…The administration of monoclonal antibodies to rat ICAM-1 and LFA-1 markedly decreased the severity of the renal disease. …”
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    Antibodies to intercellular adhesion molecule 1/lymphocyte function- associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis
  16. 1216
    por Cui, Xinle, Snapper, Clifford M.
    Publicado 2021
    “…EBV envelope proteins including gH/gL, gB and gp350 play key roles in EBV entry and infection of target cells, and neutralizing antibodies elicited by each of these proteins have shown to prevent EBV infection of target cells and markedly decrease EBV titers in the peripheral blood of humanized mice challenged with lethal dose EBV. …”
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    Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases
  17. 1217
    por Smith, Thomas J., Wagner, Robert R.
    Publicado 1967
    “…Interferon can be detected in the medium by 2 hr after viral infection and the titers usually reach a peak of 10,000 PDD(50)/ml by 4–6 hr. …”
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    RABBIT MACROPHAGE INTERFERONS : I. CONDITIONS FOR BIOSYNTHESIS BY VIRUS-INFECTED AND UNINFECTED CELLS
  18. 1218
    “…This led to considerably elevated virus titers in GLV-1h255 infected tumors, and to enhanced tumor regression. …”
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    Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors
  19. 1219
    “…Despite inducing low levels of nAb, inactivated H7N9 vaccine conferred full protection against H7N9 challenge in chickens and markedly inhibited virus shedding. Similarly, Newcastle disease virus (NDV)-vectored H7N9 vaccine induced marginal HI and nAb titers but high level of IgG antibody against H7N9 virus. …”
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    Hemagglutinin-Specific Non-neutralizing Antibody Is Essential for Protection Provided by Inactivated and Viral-Vectored H7N9 Avian Influenza Vaccines in Chickens
  20. 1220
    “…In addition, in vitro honeybees did not display the typical increase in juvenile hormone titer, which goes hand-in-hand with the initiation of foraging in colony-reared bees. …”
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    In Vitro Rearing Changes Social Task Performance and Physiology in Honeybees
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