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  1. 1221
    “…In patients with a longer follow-up, MuSK Ab titers remained suppressed, paralleling clinical response. …”
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    Long-Lasting Rituximab-Induced Reduction of Specific—But Not Total—IgG4 in MuSK-Positive Myasthenia Gravis
  2. 1222
    “…Only animals vaccinated with the oil emulsion-adjuvanted bacterin produced significant IgG2 titers following vaccination, and nonvaccinated animals produced serum IgA titers after experimental challenge. …”
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    Bovine Immune Response to Vaccination and Infection with Leptospira borgpetersenii Serovar Hardjo
  3. 1223
    “…LDRT-treated mice displayed markedly increased survival rates and reduced lung edema and airway and vascular inflammation in the lung; however, the viral titers in the lungs were unaffected. …”
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    Low-dose radiation therapy suppresses viral pneumonia by enhancing broad-spectrum anti-inflammatory responses via transforming growth factor-β production
  4. 1224
    “…Magnetic resonance imaging of the brain demonstrated bilateral enlargement/enhancement of the choroid plexi, with hydrocephalus, temporal and occipital horn entrapments, as well as marked periventricular transependymal cerebrospinal fluid (CSF) seepage. …”
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    Persistent neurological symptoms and elevated intracranial pressures in a previously healthy host with cryptococcal meningitis
  5. 1225
    “…[Image: see text] Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans (e.g., Tn antigen). …”
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    MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response
  6. 1226
    por Hu, Ying, Yuan, Jing, Wang, Bo, Ma, Liang, Zha, Yan
    Publicado 2023
    “…Belimumab was well tolerated by the patient and resulted in a rapid and marked improvement in clinical symptoms and reduction in proteinuria, serum complement levels and anti-double strand DNA antibodies titer; of note, the patient developed no infectious complications. …”
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    Efficacy of belimumab for severe childhood-onset systemic lupus erythematosus with diffuse proliferative glomerulonephritis: A case report
  7. 1227
    “…Anti-spike antibodies were detectable in 6 of 22 RA patients after 1 dose of vaccine with increasing titers after each booster dose, although the overall response was lower compared with that in healthy control individuals. …”
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    SARS-CoV-2 mRNA vaccine-induced immune responses in rheumatoid arthritis
  8. 1228
    Publicado 1976
    “…Mice immunized at least three times with T15 in adjuvants had markedly suppressed responses to subsequent immunization with PC; similarly, mice preimmunized multiple times with PC had suppressed responses to immunizations with T15. …”
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    Suppression by autogenous complementary idiotypes: the priority of the first response
  9. 1229
    Publicado 1991
    “…In the present report, we demonstrate that neonatal thymectomy of CBA/H mice results in a diminution of T cells in peripheral lymphoid organs (spleen, lymph nodes), but is followed by a marked transient (12 wk) increase in Thy- 1+ CD3+ cells in the peritoneal cavity. …”
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    Interleukin 2 abrogates the nonresponsive state of T cells expressing a forbidden T cell receptor repertoire and induces autoimmune disease in neonatally thymectomized mice
  10. 1230
    “…In a prospective analysis, a low titer of anti-WNV IgM antibodies at day 4 uniformly predicted mortality in wild-type mice. …”
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    A Critical Role for Induced IgM in the Protection against West Nile Virus Infection
  11. 1231
    “…Consistent with this, immunosuppressive therapy given to one SLE patient with digital necrosis markedly decreased the anti-ACE2 antibody titer and restored serum ACE2 activity. …”
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    Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases
  12. 1232
    “…These data suggests that the addition of high initial titers of specifically selected phages with a proper EPS depolymerase are crucial criteria in the development of phage therapy.…”
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    The T7-Related Pseudomonas putida Phage ϕ15 Displays Virion-Associated Biofilm Degradation Properties
  13. 1233
    “…WEEV distribution was confirmed by immunohistochemistry as having marked neuronal infection but very few infected glial cells. …”
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    Bioluminescent Imaging and Histopathologic Characterization of WEEV Neuroinvasion in Outbred CD-1 Mice
  14. 1234
    “…The intra-peritoneal administration of Chol-siRNA to NZB/WF1 mice resulted in a reduction of anti-DNA antibody titers, and histopathological renal scores as compared to untreated animals. …”
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    CD40 Gene Silencing Reduces the Progression of Experimental Lupus Nephritis Modulating Local Milieu and Systemic Mechanisms
  15. 1235
    “…Of the 210 clinical cases, 134 had cutoff antibody titers for Rickettsia conorii antigen for confirmation. …”
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    Cutaneous Manifestations of Spotted Fever Rickettsial Infections in the Central Province of Sri Lanka: A Descriptive Study
  16. 1236
    “…Severe respiratory syncytial virus (RSV) disease is a frequent cause of acute respiratory distress syndrome (ARDS) in young children, and is associated with marked lung epithelial injury and neutrophilic inflammation. …”
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    The caspase inhibitor zVAD increases lung inflammation in pneumovirus infection in mice
  17. 1237
    “…Especially, at 1/10-diluted eye solution for 24-hr exposure, the LDH titers of fluorometholone and diclofenac sodium markedly increased more than those of bromfenac and pranoprofen. …”
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    The Toxicity of Nonsteroidal Anti-inflammatory Eye Drops against Human Corneal Epithelial Cells in Vitro
  18. 1238
    “…Transfection with pSilencer-S or pSilencer-M (1, 2, 4 μg) markedly inhibited the viral antigen expression in dose- and time-dependent manners. …”
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    Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo
  19. 1239
    “…Administration of this rabbit TGF-β antibody in mice led to high serum titers against rabbit IgG that may have attenuated the neutralization. …”
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    TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
  20. 1240
    “…Alzheimer’s disease (AD) is characterized by progressive cognitive impairment associated with marked cholinergic neuron loss and amyloid-β (Aβ) peptide accumulation in the brain. …”
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    Immunization Against Specific Fragments of Neurotrophin p75 Receptor Protects Forebrain Cholinergic Neurons in the Olfactory Bulbectomized Mice
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