The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction

por Gomez-Paredes, Casandra, Mason, Michael A., Taxy, Bridget A., Papadopoulou, Aikaterini S., Paganetti, Paolo, Bates, Gillian P.
Publicado 2021

Functional Amyloid Formation within Mammalian Tissue

por Fowler, Douglas M, Koulov, Atanas V, Alory-Jost, Christelle, Marks, Michael S, Balch, William E, Kelly, Jeffery W
Publicado 2006

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1(G93A) Model

por Ionescu, Ariel, Gradus, Tal, Altman, Topaz, Maimon, Roy, Saraf Avraham, Noi, Geva, Michal, Hayden, Michael, Perlson, Eran
Publicado 2019

Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy

por Montague, Karli, Malik, Bilal, Gray, Anna L., La Spada, Albert R., Hanna, Michael G., Szabadkai, Gyorgy, Greensmith, Linda
Publicado 2014

Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

por Myre, Michael A., Lumsden, Amanda L., Thompson, Morgan N., Wasco, Wilma, MacDonald, Marcy E., Gusella, James F.
Publicado 2011

Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin

por Mendonça, Monique C. P., Sun, Yao, Cronin, Michael F., Lindsay, Andrew J., Cryan, John F., O’Driscoll, Caitriona M.
Publicado 2023

Unusual Structures Are Present in DNA Fragments Containing Super-Long Huntingtin CAG Repeats

por Duzdevich, Daniel, Li, Jinliang, Whang, Jhoon, Takahashi, Hirohide, Takeyasu, Kunio, Dryden, David T. F., Morton, A. Jennifer, Edwardson, J. Michael
Publicado 2011

Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial fun...

por Ho Kim, Soong, Thomas, Carlos A, André, Véronique M, Cummings, Damian M, Cepeda, Carlos, Levine, Michael S, Ehrlich, Michelle E
Publicado 2011

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

por Wang, Shao-Ming, Wu, Hsiang-En, Yasui, Yuko, Geva, Michal, Hayden, Michael, Maurice, Tangui, Cozzolino, Mauro, Su, Tsung-Ping
Publicado 2022

Pridopidine Does Not Significantly Prolong the QTc Interval at the Clinically Relevant Therapeutic Dose

por Darpo, Borje, Geva, Michal, Ferber, Georg, Goldberg, Yigal Paul, Cruz-Herranz, Andres, Mehra, Munish, Kovacs, Richard, Hayden, Michael R.
Publicado 2023

Planning for Prevention of Parkinson Disease: Now Is the Time

por Crotty, Grace F., Keavney, Jessi L., Alcalay, Roy N., Marek, Kenneth, Marshall, Gad A., Rosas, H. Diana, Schwarzschild, Michael A.
Publicado 2022

Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs

por Das, Michael R., Chang, Yeonji, Anderson, Rachel, Saunders, Reuben A., Zhang, Nan, Tomberlin, Colson P., Vale, Ronald D., Jain, Ankur
Publicado 2023

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

por Ehrnhoefer, Dagmar E., Skotte, Niels H., Savill, Jane, Nguyen, Yen T. N., Ladha, Safia, Cao, Li-Ping, Dullaghan, Edie, Hayden, Michael R.
Publicado 2011

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity

por Fields, Jerel A., Overk, Cassia, Adame, Anthony, Florio, Jazmin, Mante, Michael, Pineda, Andrea, Desplats, Paula, Rockenstein, Edward, Achim, Cristian, Masliah, Eliezer
Publicado 2016

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

por Sachamitr, Patty, Ho, Jolene C., Ciamponi, Felipe E., Ba-Alawi, Wail, Coutinho, Fiona J., Guilhamon, Paul, Kushida, Michelle M., Cavalli, Florence M. G., Lee, Lilian, Rastegar, Naghmeh, Vu, Victoria, Sánchez-Osuna, María, Coulombe-Huntington, Jasmin, Kanshin, Evgeny, Whetstone, Heather, Durand, Mathieu, Thibault, Philippe, Hart, Kirsten, Mangos, Maria, Veyhl, Joseph, Chen, Wenjun, Tran, Nhat, Duong, Bang-Chi, Aman, Ahmed M., Che, Xinghui, Lan, Xiaoyang, Whitley, Owen, Zaslaver, Olga, Barsyte-Lovejoy, Dalia, Richards, Laura M., Restall, Ian, Caudy, Amy, Röst, Hannes L., Bonday, Zahid Quyoom, Bernstein, Mark, Das, Sunit, Cusimano, Michael D., Spears, Julian, Bader, Gary D., Pugh, Trevor J., Tyers, Mike, Lupien, Mathieu, Haibe-Kains, Benjamin, Artee Luchman, H., Weiss, Samuel, Massirer, Katlin B., Prinos, Panagiotis, Arrowsmith, Cheryl H., Dirks, Peter B.
Publicado 2021

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

por Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard
Publicado 2019

TRiC’s tricks inhibit huntingtin aggregation

por Shahmoradian, Sarah H, Galaz-Montoya, Jesus G, Schmid, Michael F, Cong, Yao, Ma, Boxue, Spiess, Christoph, Frydman, Judith, Ludtke, Steven J, Chiu, Wah
Publicado 2013

Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast

por Gong, He, Romanova, Nina V., Allen, Kim D., Chandramowlishwaran, Pavithra, Gokhale, Kavita, Newnam, Gary P., Mieczkowski, Piotr, Sherman, Michael Y., Chernoff, Yury O.
Publicado 2012

Laquinimod treatment in the R6/2 mouse model

por Ellrichmann, Gisa, Blusch, Alina, Fatoba, Oluwaseun, Brunner, Janine, Reick, Christiane, Hayardeny, Liat, Hayden, Michael, Sehr, Dominik, Winklhofer, Konstanze F., Saft, Carsten, Gold, Ralf
Publicado 2017

Exome Sequencing–Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants

por Manickam, Kandamurugu, Buchanan, Adam H., Schwartz, Marci L. B., Hallquist, Miranda L. G., Williams, Janet L., Rahm, Alanna Kulchak, Rocha, Heather, Savatt, Juliann M., Evans, Alyson E., Butry, Loren M., Lazzeri, Amanda L., Lindbuchler, D’Andra M., Flansburg, Carroll N., Leeming, Rosemary, Vogel, Victor G., Lebo, Matthew S., Mason-Suares, Heather M., Hoskinson, Derick C., Abul-Husn, Noura S., Dewey, Frederick E., Overton, John D., Reid, Jeffrey G., Baras, Aris, Willard, Huntington F., McCormick, Cara Z., Krishnamurthy, Sarath B., Hartzel, Dustin N., Kost, Korey A., Lavage, Daniel R., Sturm, Amy C., Frisbie, Lauren R., Person, T. Nate, Metpally, Raghu P., Giovanni, Monica A., Lowry, Lacy E., Leader, Joseph B., Ritchie, Marylyn D., Carey, David J., Justice, Anne E., Kirchner, H. Lester, Faucett, W. Andrew, Williams, Marc S., Ledbetter, David H., Murray, Michael F.
Publicado 2018