Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

por Arnoux, Isabelle, Willam, Michael, Griesche, Nadine, Krummeich, Jennifer, Watari, Hirofumi, Offermann, Nina, Weber, Stephanie, Narayan Dey, Partha, Chen, Changwei, Monteiro, Olivia, Buettner, Sven, Meyer, Katharina, Bano, Daniele, Radyushkin, Konstantin, Langston, Rosamund, Lambert, Jeremy J, Wanker, Erich, Methner, Axel, Krauss, Sybille, Schweiger, Susann, Stroh, Albrecht
Publicado 2018

Perceptions of genetic discrimination among people at risk for Huntington’s disease: a cross sectional survey

por Bombard, Yvonne, Veenstra, Gerry, Friedman, Jan M, Creighton, Susan, Currie, Lauren, Paulsen, Jane S, Bottorff, Joan L, Hayden, Michael R
Publicado 2009

The Vasopressin 1a Receptor Antagonist SRX246 Reduces Aggressive Behavior in Huntington’s Disease

por Maibach, Hilda T., Brownstein, Michael J., Hersch, Steven M., Anderson, Karen E., Itzkowitz, Debra E., Damiano, Eve M., Simon, Neal G.
Publicado 2022

Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice

por Wang, Nan, Gray, Michelle, Lu, Xiao-Hong, Cantle, Jeffrey P., Holley, Sandra M., Greiner, Erin, Gu, Xiaofeng, Shirasaki, Dyna, Cepeda, Carlos, Li, Yuqing, Dong, Hongwei, Levine, Michael S., Yang, X. William
Publicado 2014

Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues

por Neueder, Andreas, Kojer, Kerstin, Hering, Tanja, Lavery, Daniel J., Chen, Jian, Birth, Nathalie, Hallitsch, Jaqueline, Trautmann, Sonja, Parker, Jennifer, Flower, Michael, Sethi, Huma, Haider, Salman, Lee, Jong-Min, Tabrizi, Sarah J., Orth, Michael
Publicado 2022

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

por Paryani, Fahad, Kwon, Ji-Sun, Ng, Chris W, Madden, Nacoya, Ofori, Kenneth, Tang, Alice, Lu, Hong, Li, Juncheng, Mahajan, Aayushi, Davidson, Shawn M., Basile, Anna, McHugh, Caitlin, Vonsattel, Jean Paul, Hickman, Richard, Zody, Michael, Houseman, David E., Goldman, James E., Yoo, Andrew S., Menon, Vilas, Al-Dalahmah, Osama
Publicado 2023

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

por Machiela, Emily, Jeloka, Ritika, Caron, Nicholas S., Mehta, Shagun, Schmidt, Mandi E., Baddeley, Helen J. E., Tom, Colton M., Polturi, Nalini, Xie, Yuanyun, Mattis, Virginia B., Hayden, Michael R., Southwell, Amber L.
Publicado 2020

Striatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington Disease

por Kolodziejczyk, Karolina, Parsons, Matthew P., Southwell, Amber L., Hayden, Michael R., Raymond, Lynn A.
Publicado 2014

A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice

por Acuña, Aníbal I., Esparza, Magdalena, Kramm, Carlos, Beltrán, Felipe A., Parra, Alejandra V., Cepeda, Carlos, Toro, Carlos A., Vidal, René L., Hetz, Claudio, Concha, Ilona I., Brauchi, Sebastián, Levine, Michael S., Castro, Maite A.
Publicado 2013

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

por Ehrnhoefer, Dagmar E., Martin, Dale D. O., Schmidt, Mandi E., Qiu, Xiaofan, Ladha, Safia, Caron, Nicholas S., Skotte, Niels H., Nguyen, Yen T. N., Vaid, Kuljeet, Southwell, Amber L., Engemann, Sabine, Franciosi, Sonia, Hayden, Michael R.
Publicado 2018

Dysfunctional mitochondrial respiration in the striatum of the Huntington’s disease transgenic R6/2 mouse model

por Aidt, Frederik Heurlin, Nielsen, Signe Marie Borch, Kanters, Jørgen, Pesta, Dominik, Nielsen, Troels Tolstrup, Nørremølle, Anne, Hasholt, Lis, Christiansen, Michael, Hagen, Christian Munch
Publicado 2013

Post-mortem Findings in Huntington’s Deep Brain Stimulation: A Moving Target Due to Atrophy

por Vedam-Mai, Vinata, Martinez-Ramirez, Daniel, Hilliard, Justin D., Carbunaru, Samuel, Yachnis, Anthony T., Bloom, Joshua, Keeling, Peyton, Awe, Lisa, Foote, Kelly D., Okun, Michael S.
Publicado 2016

MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1

por Flower, Michael, Lomeikaite, Vilija, Ciosi, Marc, Cumming, Sarah, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Monckton, Darren G, Tabrizi, Sarah J
Publicado 2019

Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease

por Ooi, Jolene, Hayden, Michael R., Pouladi, Mahmoud A.
Publicado 2014

Intact sensory-motor network structure and function in far from onset premanifest Huntington’s disease

por Gorges, Martin, Müller, Hans-Peter, Mayer, Isabella Maria Sophie, Grupe, Gesa Sophie, Kammer, Thomas, Grön, Georg, Kassubek, Jan, Landwehrmeyer, G. Bernhard, Wolf, Robert Christian, Orth, Michael
Publicado 2017

siRNA screen identifies QPCT as a druggable target for Huntington’s disease

por Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Dami, Teresa Ed, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P., Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P., Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O’Kane, Cahir J., Caricasole, Andrea, Rubinsztein, David C.
Publicado 2015

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

por Gu, Xiaofeng, André, Véronique M, Cepeda, Carlos, Li, Shi-Hua, Li, Xiao-Jiang, Levine, Michael S, Yang, X William
Publicado 2007

Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells

por Mueller, Kaly A., Glajch, Kelly E., Huizenga, Megan N., Wilson, Remi A., Granucci, Eric J., Dios, Amanda M., Tousley, Adelaide R., Iuliano, Maria, Weisman, Elizabeth, LaQuaglia, Michael J., DiFiglia, Marian, Kegel-Gleason, Kimberly, Vakili, Khashayar, Sadri-Vakili, Ghazaleh
Publicado 2018

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease

por Smith-Dijak, Amy I., Nassrallah, Wissam B., Zhang, Lily Y. J., Geva, Michal, Hayden, Michael R., Raymond, Lynn A.
Publicado 2019

Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1

por Lobanov, Sergey V., McAllister, Branduff, McDade-Kumar, Mia, Landwehrmeyer, G. Bernhard, Orth, Michael, Rosser, Anne E., Paulsen, Jane S., Lee, Jong-Min, MacDonald, Marcy E., Gusella, James F., Long, Jeffrey D., Ryten, Mina, Williams, Nigel M., Holmans, Peter, Massey, Thomas H., Jones, Lesley
Publicado 2022