Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

por Tong, Xiaoping, Ao, Yan, Faas, Guido C., Nwaobi, Sinifunanya E., Xu, Ji, Haustein, Martin D., Anderson, Mark A., Mody, Istvan, Olsen, Michelle L., Sofroniew, Michael V., Khakh, Baljit S.
Publicado 2014

Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model

por Landles, Christian, Milton, Rebecca E, Ali, Nadira, Flomen, Rachel, Flower, Michael, Schindler, Franziska, Gomez-Paredes, Casandra, Bondulich, Marie K, Osborne, Georgina F, Goodwin, Daniel, Salsbury, Grace, Benn, Caroline L, Sathasivam, Kirupa, Smith, Edward J, Tabrizi, Sarah J, Wanker, Erich E, Bates, Gillian P
Publicado 2020

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease

por Miniarikova, Jana, Zanella, Ilaria, Huseinovic, Angelina, van der Zon, Tom, Hanemaaijer, Evelyn, Martier, Raygene, Koornneef, Annemart, Southwell, Amber L, Hayden, Michael R, van Deventer, Sander J, Petry, Harald, Konstantinova, Pavlina
Publicado 2016

A PET-CT study on neuroinflammation in Huntington’s disease patients participating in a randomized trial with laquinimod

por Roussakis, Andreas-Antonios, Gennaro, Marta, Gordon, Mark Forrest, Reilmann, Ralf, Borowsky, Beth, Rynkowski, Gail, Lao-Kaim, Nicholas P, Papoutsou, Zoe, Savola, Juha-Matti, Hayden, Michael R, Owen, David R, Kalk, Nicola, Lingford-Hughes, Anne, Gunn, Roger N, Searle, Graham, Tabrizi, Sarah J, Piccini, Paola
Publicado 2023

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

por Carroll, Jeffrey B, Southwell, Amber L, Graham, Rona K, Lerch, Jason P, Ehrnhoefer, Dagmar E, Cao, Li-Ping, Zhang, Wei-Ning, Deng, Yu, Bissada, Nagat, Henkelman, R Mark, Hayden, Michael R
Publicado 2011

Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease

por Mullari, Meeli, Fossat, Nicolas, Skotte, Niels H., Asenjo-Martinez, Andrea, Humphreys, David T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels K. H., Nielsen, Michael L.
Publicado 2023

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

por Skotte, Niels H., Southwell, Amber L., Østergaard, Michael E., Carroll, Jeffrey B., Warby, Simon C., Doty, Crystal N., Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T., Freier, Susan M., Hung, Gene, Seth, Punit P., Bennett, C. Frank, Swayze, Eric E., Hayden, Michael R.
Publicado 2014

Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Compreh...

por Wang, James K. T., Langfelder, Peter, Horvath, Steve, Palazzolo, Michael J.
Publicado 2017

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

por Van Raamsdonk, Jeremy M, Pearson, Jacqueline, Murphy, Zoe, Hayden, Michael R, Leavitt, Blair R
Publicado 2006

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease

por Li, Mei, Yasumura, Douglas, Ma, Aye Aye K., Matthes, Michael T., Yang, Haidong, Nielson, Gregory, Huang, Yong, Szoka, Francis C., LaVail, Matthew M., Diamond, Marc I.
Publicado 2013

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington’s disease motor onset

por Ramos, Eliana Marisa, Latourelle, Jeanne C., Gillis, Tammy, Mysore, Jayalakshmi S., Squitieri, Ferdinando, Di Pardo, Alba, Di Donato, Stefano, Gellera, Cinzia, Hayden, Michael R., Morrison, Patrick J., Nance, Martha, Ross, Christopher A., Margolis, Russell L., Gomez-Tortosa, Estrella, Ayuso, Carmen, Suchowersky, Oksana, Trent, Ronald J., McCusker, Elizabeth, Novelletto, Andrea, Frontali, Marina, Jones, Randi, Ashizawa, Tetsuo, Frank, Samuel, Saint-Hilaire, Marie-Helene, Hersch, Steven M., Rosas, Herminia D., Lucente, Diane, Harrison, Madaline B., Zanko, Andrea, Abramson, Ruth K., Marder, Karen, Gusella, James F., Lee, Jong-Min, Alonso, Isabel, Sequeiros, Jorge, Myers, Richard H., MacDonald, Marcy E.
Publicado 2013

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

por Teo, Roy Tang Yi, Hong, Xin, Yu-Taeger, Libo, Huang, Yihui, Tan, Liang Juin, Xie, Yuanyun, To, Xuan Vinh, Guo, Ling, Rajendran, Reshmi, Novati, Arianna, Calaminus, Carsten, Riess, Olaf, Hayden, Michael R., Nguyen, Huu P., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Publicado 2016

Failure to Thrive: Impaired BDNF Transport along the Cortical–Striatal Axis in Mouse Q140 Neurons of Huntington’s Disease

por Maloney, Michael T., Wang, Wei, Bhowmick, Sumana, Millan, Ivan, Kapur, Mridu, Herrera, Nicolas, Frost, Everett, Zhang, Elena Y., Song, Scott, Wang, Melissa, Park, Amelia Bora, Yao, Annabelle Y., Yang, Yanmin
Publicado 2023

Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington’s Disease Mice

por Botelho, Eliã P., Wang, Elizabeth, Chen, Jane Y., Holley, Sandra, Andre, Veronique, Cepeda, Carlos, Levine, Michael S.
Publicado 2014

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

por Lim, Ryan G., Al-Dalahmah, Osama, Wu, Jie, Gold, Maxwell P., Reidling, Jack C., Tang, Guomei, Adam, Miriam, Dansu, David K., Park, Hye-Jin, Casaccia, Patrizia, Miramontes, Ricardo, Reyes-Ortiz, Andrea M., Lau, Alice, Hickman, Richard A., Khan, Fatima, Paryani, Fahad, Tang, Alice, Ofori, Kenneth, Miyoshi, Emily, Michael, Neethu, McClure, Nicolette, Flowers, Xena E., Vonsattel, Jean Paul, Davidson, Shawn, Menon, Vilas, Swarup, Vivek, Fraenkel, Ernest, Goldman, James E., Thompson, Leslie M.
Publicado 2022

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

por Reyes-Ortiz, Andrea M., Abud, Edsel M., Burns, Mara S., Wu, Jie, Hernandez, Sarah J., McClure, Nicolette, Wang, Keona Q., Schulz, Corey J., Miramontes, Ricardo, Lau, Alice, Michael, Neethu, Miyoshi, Emily, Van Vactor, David, Reidling, John C., Blurton-Jones, Mathew, Swarup, Vivek, Poon, Wayne W., Lim, Ryan G., Thompson, Leslie M.
Publicado 2022

A Remote Digital Monitoring Platform to Assess Cognitive and Motor Symptoms in Huntington Disease: Cross-sectional Validation Study

por Lipsmeier, Florian, Simillion, Cedric, Bamdadian, Atieh, Tortelli, Rosanna, Byrne, Lauren M, Zhang, Yan-Ping, Wolf, Detlef, Smith, Anne V, Czech, Christian, Gossens, Christian, Weydt, Patrick, Schobel, Scott A, Rodrigues, Filipe B, Wild, Edward J, Lindemann, Michael
Publicado 2022

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

por Wu, Gong-Her, Smith-Geater, Charlene, Galaz-Montoya, Jesús G., Gu, Yingli, Gupte, Sanket R., Aviner, Ranen, Mitchell, Patrick G., Hsu, Joy, Miramontes, Ricardo, Wang, Keona Q., Geller, Nicolette R., Hou, Cathy, Danita, Cristina, Joubert, Lydia-Marie, Schmid, Michael F., Yeung, Serena, Frydman, Judith, Mobley, William, Wu, Chengbiao, Thompson, Leslie M., Chiu, Wah
Publicado 2023

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

por Hickey, Miriam A, Zhu, Chunni, Medvedeva, Vera, Lerner, Renata P, Patassini, Stefano, Franich, Nicholas R, Maiti, Panchanan, Frautschy, Sally A, Zeitlin, Scott, Levine, Michael S, Chesselet, Marie-Françoise
Publicado 2012

CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington’s disease

por Yu, Dahyun, Zarate, Nicole, White, Angel, Coates, De’jah, Tsai, Wei, Nanclares, Carmen, Cuccu, Francesco, Yue, Johnny S., Brown, Taylor G., Mansky, Rachel H., Jiang, Kevin, Kim, Hyuck, Nichols-Meade, Tessa, Larson, Sarah N., Gundry, Katherine, Zhang, Ying, Tomas-Zapico, Cristina, Lucas, Jose J., Benneyworth, Michael, Öz, Gülin, Cvetanovic, Marija, Araque, Alfonso, Gomez-Pastor, Rocio
Publicado 2022