Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

por Garcia-Miralles, Marta, Hong, Xin, Tan, Liang Juin, Caron, Nicholas S., Huang, Yihui, To, Xuan Vinh, Lin, Rachel Yanping, Franciosi, Sonia, Papapetropoulos, Spyros, Hayardeny, Liat, Hayden, Michael R., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Publicado 2016

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice

por Schindler, Franziska, Praedel, Nicole, Neuendorf, Nancy, Kunz, Severine, Schnoegl, Sigrid, Mason, Michael A., Taxy, Bridget A., Bates, Gillian P., Khoshnan, Ali, Priller, Josef, Grimm, Jan, Maier, Marcel, Boeddrich, Annett, Wanker, Erich E.
Publicado 2021

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease

por Hensman Moss, Davina J., Flower, Michael D., Lo, Kitty K., Miller, James R. C., van Ommen, Gert-Jan B., ’t Hoen, Peter A. C., Stone, Timothy C., Guinee, Amelia, Langbehn, Douglas R., Jones, Lesley, Plagnol, Vincent, van Roon-Mom, Willeke M. C., Holmans, Peter, Tabrizi, Sarah J.
Publicado 2017

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

por Southwell, Amber L., Smith, Stephen E.P., Davis, Tessa R., Caron, Nicholas S., Villanueva, Erika B., Xie, Yuanyun, Collins, Jennifer A., Li Ye, Min, Sturrock, Aaron, Leavitt, Blair R., Schrum, Adam G., Hayden, Michael R.
Publicado 2015

Correction to: CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease

por Yu, Dahyun, Zarate, Nicole, White, Angel, Coates, De’jah, Tsai, Wei, Nanclares, Carmen, Cuccu, Francesco, Yue, Johnny S., Brown, Taylor G., Mansky, Rachel H., Jiang, Kevin, Kim, Hyuck, Nichols‑Meade, Tessa, Larson, Sarah N., Gundry, Katherine, Zhang, Ying, Tomas‑Zapico, Cristina, Lucas, Jose J., Benneyworth, Michael, Öz, Gülin, Cvetanovic, Marija, Araque, Alfonso, Gomez‑Pastor, Rocio
Publicado 2022

Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease1,2,3

por Holley, Sandra M., Joshi, Prasad R., Parievsky, Anna, Galvan, Laurie, Chen, Jane Y., Fisher, Yvette E., Huynh, My N., Cepeda, Carlos, Levine, Michael S.
Publicado 2015

Mixed longitudinal and cross-sectional analyses of deep gray matter and white matter using diffusion weighted images in premanifest and manifest Huntington’s disease

por Hu, Beini, Younes, Laurent, Bu, Xuan, Liu, Chin-Fu, Tilak Ratnanather, J., Paulsen, Jane, Georgiou-Karistianis, Nellie, Miller, Michael I., Ross, Christopher, Faria, Andreia V.
Publicado 2023

Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease

por Tano, Vincent, Utami, Kagistia Hana, Yusof, Nur Amirah Binte Mohammad, Bégin, Jocelyn, Tan, Willy Wei Li, Pouladi, Mahmoud A., Langley, Sarah R.
Publicado 2023

Characterizing patient compliance over six months in remote digital trials of Parkinson’s and Huntington disease

por Cohen, Shani, Waks, Zeev, Elm, Jordan J., Gordon, Mark Forrest, Grachev, Igor D., Navon-Perry, Leehee, Fine, Shai, Grossman, Iris, Papapetropoulos, Spyros, Savola, Juha-Matti
Publicado 2018

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease

por Chen, Jane Y., Wang, Elizabeth A., Galvan, Laurie, Huynh, My, Joshi, Prasad, Cepeda, Carlos, Levine, Michael S.
Publicado 2013

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington’s Disease Model through the Application of Quantitative Systems Pharmacology

por Pei, Fen, Li, Hongchun, Henderson, Mark J., Titus, Steven A., Jadhav, Ajit, Simeonov, Anton, Cobanoglu, Murat Can, Mousavi, Seyed H., Shun, Tongying, McDermott, Lee, Iyer, Prema, Fioravanti, Michael, Carlisle, Diane, Friedlander, Robert M., Bahar, Ivet, Taylor, D. Lansing, Lezon, Timothy R., Stern, Andrew M., Schurdak, Mark E.
Publicado 2017

Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study

por Li, Jian-Liang, Hayden, Michael R, Warby, Simon C, Durr, Alexandra, Morrison, Patrick J, Nance, Martha, Ross, Christopher A, Margolis, Russell L, Rosenblatt, Adam, Squitieri, Ferdinando, Frati, Luigi, Gómez-Tortosa, Estrella, García, Carmen Ayuso, Suchowersky, Oksana, Klimek, Mary Lou, Trent, Ronald JA, McCusker, Elizabeth, Novelletto, Andrea, Frontali, Marina, Paulsen, Jane S, Jones, Randi, Ashizawa, Tetsuo, Lazzarini, Alice, Wheeler, Vanessa C, Prakash, Ranjana, Xu, Gang, Djoussé, Luc, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, Hakky, Michael, Cupples, L Adrienne, Saint-Hilaire, Marie H, Cha, Jang-Ho J, Hersch, Steven M, Penney, John B, Harrison, Madaline B, Perlman, Susan L, Zanko, Andrea, Abramson, Ruth K, Lechich, Anthony J, Duckett, Ayana, Marder, Karen, Conneally, P Michael, Gusella, James F, MacDonald, Marcy E, Myers, Richard H
Publicado 2006

DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease

por Schmidt, Mandi E., Caron, Nicholas S., Aly, Amirah E., Lemarié, Fanny L., Dal Cengio, Louisa, Ko, Yun, Lazic, Nikola, Anderson, Lisa, Nguyen, Betty, Raymond, Lynn A., Hayden, Michael R.
Publicado 2020

FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease

por Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D., Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel, Tabrizi, Sarah J.
Publicado 2021

Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset

por McAllister, Branduff, Donaldson, Jasmine, Binda, Caroline S., Powell, Sophie, Chughtai, Uroosa, Edwards, Gareth, Stone, Joseph, Lobanov, Sergey, Elliston, Linda, Schuhmacher, Laura-Nadine, Rees, Elliott, Menzies, Georgina, Ciosi, Marc, Maxwell, Alastair, Chao, Michael J., Hong, Eun Pyo, Lucente, Diane, Wheeler, Vanessa, Lee, Jong-Min, MacDonald, Marcy E., Long, Jeffrey D., Aylward, Elizabeth H., Landwehrmeyer, G. Bernhard, Rosser, Anne E., Paulsen, Jane S., Williams, Nigel M., Gusella, James F., Monckton, Darren G., Allen, Nicholas D., Holmans, Peter, Jones, Lesley, Massey, Thomas H.
Publicado 2022

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75(NTR) Ligand LM11A-31

por Simmons, Danielle A., Mills, Brian D., Butler III, Robert R., Kuan, Jason, McHugh, Tyne L. M., Akers, Carolyn, Zhou, James, Syriani, Wassim, Grouban, Maged, Zeineh, Michael, Longo, Frank M.
Publicado 2021

Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset

por Ramos, Eliana Marisa, Latourelle, Jeanne C., Lee, Ji-Hyun, Gillis, Tammy, Mysore, Jayalakshmi S., Squitieri, Ferdinando, Di Pardo, Alba, Di Donato, Stefano, Hayden, Michael R., Morrison, Patrick J., Nance, Martha, Ross, Christopher A., Margolis, Russell L., Gomez-Tortosa, Estrella, Ayuso, Carmen, Suchowersky, Oksana, Trent, Ronald J., McCusker, Elizabeth, Novelletto, Andrea, Frontali, Marina, Jones, Randi, Ashizawa, Tetsuo, Frank, Samuel, Saint-Hilaire, Marie-Helene, Hersch, Steven M., Rosas, Herminia D., Lucente, Diane, Harrison, Madaline B., Zanko, Andrea, Marder, Karen, Gusella, James F., Lee, Jong-Min, Alonso, Isabel, Sequeiros, Jorge, Myers, Richard H., MacDonald, Marcy E.
Publicado 2012

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

por Reidling, Jack C., Relaño-Ginés, Aroa, Holley, Sandra M., Ochaba, Joseph, Moore, Cindy, Fury, Brian, Lau, Alice, Tran, Andrew H., Yeung, Sylvia, Salamati, Delaram, Zhu, Chunni, Hatami, Asa, Cepeda, Carlos, Barry, Joshua A., Kamdjou, Talia, King, Alvin, Coleal-Bergum, Dane, Franich, Nicholas R., LaFerla, Frank M., Steffan, Joan S., Blurton-Jones, Mathew, Meshul, Charles K., Bauer, Gerhard, Levine, Michael S., Chesselet, Marie-Francoise, Thompson, Leslie M.
Publicado 2017

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease

por Bragg, Robert M., Coffey, Sydney R., Weston, Rory M., Ament, Seth A., Cantle, Jeffrey P., Minnig, Shawn, Funk, Cory C., Shuttleworth, Dominic D., Woods, Emily L., Sullivan, Bonnie R., Jones, Lindsey, Glickenhaus, Anne, Anderson, John S., Anderson, Michael D., Dunnett, Stephen B., Wheeler, Vanessa C., MacDonald, Marcy E., Brooks, Simon P., Price, Nathan D., Carroll, Jeffrey B.
Publicado 2017

Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease

por Bragg, Robert M., Coffey, Sydney R., Weston, Rory M., Ament, Seth A., Cantle, Jeffrey P., Minnig, Shawn, Funk, Cory C., Shuttleworth, Dominic D., Woods, Emily L., Sullivan, Bonnie R., Jones, Lindsey, Glickenhaus, Anne, Anderson, John S., Anderson, Michael D., Dunnett, Stephen B., Wheeler, Vanessa C., MacDonald, Marcy E., Brooks, Simon P., Price, Nathan D., Carroll, Jeffrey B.
Publicado 2017