Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington's disease models

por Marco, Sonia, Giralt, Albert, Petrovic, Milos M., Pouladi, Mahmoud A., Martínez-Turrillas, Rebeca, Martínez-Hernández, José, Kaltenbach, Linda S., Torres-Peraza, Jesús, Graham, Rona K., Watanabe, Masahiko, Luján, Rafael, Nakanishi, Nobuki, Lipton, Stuart A., Lo, Donald C., Hayden, Michael R., Alberch, Jordi, Wesseling, John F., Pérez-Otaño, Isabel
Publicado 2013

A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes

por Ciosi, Marc, Maxwell, Alastair, Cumming, Sarah A., Hensman Moss, Davina J., Alshammari, Asma M., Flower, Michael D., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Holmans, Peter, Jones, Lesley, Langbehn, Douglas R., Kwak, Seung, Tabrizi, Sarah J., Monckton, Darren G.
Publicado 2019

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

por Caron, Nicholas S, Southwell, Amber L, Brouwers, Cynthia C, Cengio, Louisa Dal, Xie, Yuanyun, Black, Hailey Findlay, Anderson, Lisa M, Ko, Seunghyun, Zhu, Xiang, van Deventer, Sander J, Evers, Melvin M, Konstantinova, Pavlina, Hayden, Michael R
Publicado 2020

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease

por Menalled, Liliana B., Kudwa, Andrea E., Oakeshott, Steve, Farrar, Andrew, Paterson, Neil, Filippov, Igor, Miller, Sam, Kwan, Mei, Olsen, Michael, Beltran, Jose, Torello, Justin, Fitzpatrick, Jon, Mushlin, Richard, Cox, Kimberly, McConnell, Kristi, Mazzella, Matthew, He, Dansha, Osborne, Georgina F., Al-Nackkash, Rand, Bates, Gill P., Tuunanen, Pasi, Lehtimaki, Kimmo, Brunner, Dani, Ghavami, Afshin, Ramboz, Sylvie, Park, Larry, Macdonald, Douglas, Munoz-Sanjuan, Ignacio, Howland, David
Publicado 2014

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [(18)F] fluspidine and [(18)F] fallypride PET study

por Grachev, Igor D., Meyer, Philipp M., Becker, Georg A., Bronzel, Marcus, Marsteller, Doug, Pastino, Gina, Voges, Ole, Rabinovich, Laura, Knebel, Helena, Zientek, Franziska, Rullmann, Michael, Sattler, Bernhard, Patt, Marianne, Gerhards, Thilo, Strauss, Maria, Kluge, Andreas, Brust, Peter, Savola, Juha-Matti, Gordon, Mark F., Geva, Michal, Hesse, Swen, Barthel, Henryk, Hayden, Michael R., Sabri, Osama
Publicado 2020

Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington’s Disease Patients—A Randomized Phase 2 Clinical Trial

por Brownstein, Michael J., Simon, Neal G., Long, Jeffrey D., Yankey, Jon, Maibach, Hilda T., Cudkowicz, Merit, Coffey, Christopher, Conwit, Robin A., Lungu, Codrin, Anderson, Karen E., Hersch, Steven M., Ecklund, Dixie J., Damiano, Eve M., Itzkowitz, Debra E., Lu, Shifang, Chase, Marianne K., Shefner, Jeremy M., McGarry, Andrew, Thornell, Brenda, Gladden, Catherine, Costigan, Michele, O’Suilleabhain, Padraig, Marshall, Frederick J., Chesire, Amy M., Deritis, Paul, Adams, Jamie L., Hedera, Peter, Lowen, Kelly, Rosas, H. Diana, Hiller, Amie L., Quinn, Joseph, Keith, Kellie, Duker, Andrew P., Gruenwald, Christina, Molloy, Angela, Jacob, Cara, Factor, Stewart, Sperin, Elaine, Bega, Danny, Brown, Zsazsa R., Seeberger, Lauren C., Sung, Victor W., Benge, Melanie, Kostyk, Sandra K., Daley, Allison M., Perlman, Susan, Suski, Valerie, Conlon, Patricia, Barrett, Matthew J., Lowenhaupt, Stephanie, Quigg, Mark, Perlmutter, Joel S., Wright, Brenton A., Most, Elaine, Schwartz, Guy J., Lamb, Jessica, Chuang, Rosalind S., Singer, Carlos, Marder, Karen, Moran, Joyce A., Singleton, John R., Zorn, Meghan, Wall, Paola V., Dubinsky, Richard M., Gray, Carolyn, Drazinic, Carolyn
Publicado 2020

Maintaining Laboratory Services in a Rural Academic Medical Center During the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic: What Worked and What Did Not (February 29–Ma...

por Wells, Wendy A., Harhen, Michael T., Calderwood, Michael S., Altomare, Antonia L., Huntington, Jonathan T., Merrens, Edward J., Tsongalis, Gregory J.
Publicado 2020

Perceptions About Mindfulness and Text Messaging for Smoking Cessation in Vietnam: Results From a Qualitative Study

por Do, Vuong Van, Spears, Claire Adams, Van Minh, Hoang, Huang, Jidong, Redmon, Pamela Buffington, Xuan Long, Nguyen, Eriksen, Michael Paul
Publicado 2020

Antimicrobial resistance point-of-care testing for gonorrhoea treatment regimens: cost-effectiveness and impact on ceftriaxone use of five hypothetical strategies compared with sta...

por Harding-Esch, Emma M, Huntington, Susie E, Harvey, Michael J, Weston, Georgie, Broad, Claire E, Adams, Elisabeth J, Sadiq, S Tariq
Publicado 2020

B-cell lymphoma 2 inhibitor venetoclax treatment of a patient with cutaneous T-cell lymphoma

por King, Amber Loren O., Mirza, Fatima N., Lewis, Julia M., Carlson, Kacie R., Huntington, Scott, Foss, Francine M., Girardi, Michael
Publicado 2020

Nfil3 is required for the development of all innate lymphoid cell subsets

por Seillet, Cyril, Rankin, Lucille C., Groom, Joanna R., Mielke, Lisa A., Tellier, Julie, Chopin, Michael, Huntington, Nicholas D., Belz, Gabrielle T., Carotta, Sebastian
Publicado 2014

Modelling-based evaluation of the costs, benefits and cost-effectiveness of multipathogen point-of-care tests for sexually transmitted infections in symptomatic genitourinary medic...

por Huntington, Susie E, Burns, Richéal M, Harding-Esch, Emma, Harvey, Michael J, Hill-Tout, Rachel, Fuller, Sebastian S, Adams, Elisabeth J, Sadiq, S Tariq
Publicado 2018

Key innovations and the diversification of Hymenoptera

por Blaimer, Bonnie B., Santos, Bernardo F., Cruaud, Astrid, Gates, Michael W., Kula, Robert R., Mikó, István, Rasplus, Jean-Yves, Smith, David R., Talamas, Elijah J., Brady, Seán G., Buffington, Matthew L.
Publicado 2023

Platelet and Monocyte Activation After Transcatheter Aortic Valve Replacement (POTENT-TAVR): A Mechanistic Randomized Trial of Ticagrelor Versus Clopidogrel

por Zidar, David A., Al-Kindi, Sadeer, Longenecker, Chris T., Parikh, Sahil A., Gillombardo, Carl B., Funderburg, Nicholas T., Juchnowski, Steven, Huntington, Lauren, Jenkins, Trevor, Nmai, Christopher, Osnard, Michael, Shishebhor, Mehdi, Filby, Steven, Tatsuoka, Curtis, Lederman, Michael M., Blackstone, Eugene, Attizzani, Guilherme, Simon, Daniel I.
Publicado 2023

Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality

por Mast, Fred D., Navare, Arti T., van der Sloot, Almer M., Coulombe-Huntington, Jasmin, Rout, Michael P., Baliga, Nitin S., Kaushansky, Alexis, Chait, Brian T., Aderem, Alan, Rice, Charles M., Sali, Andrej, Tyers, Mike, Aitchison, John D.
Publicado 2020

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

por Hill, Spencer, Reichermeier, Kurt, Scott, Daniel C, Samentar, Lorena, Coulombe-Huntington, Jasmin, Izzi, Luisa, Tang, Xiaojing, Ibarra, Rebeca, Bertomeu, Thierry, Moradian, Annie, Sweredoski, Michael J, Caberoy, Nora, Schulman, Brenda A, Sicheri, Frank, Tyers, Mike, Kleiger, Gary
Publicado 2019

Analysis of the Complete Genome of the Alkaliphilic and Phototrophic Firmicute Heliorestis convoluta Strain HH(T)

por Dewey, Emma D., Stokes, Lynn M., Burchell, Brad M., Shaffer, Kathryn N., Huntington, Austin M., Baker, Jennifer M., Nadendla, Suvarna, Giglio, Michelle G., Bender, Kelly S., Touchman, Jeffrey W., Blankenship, Robert E., Madigan, Michael T., Sattley, W. Matthew
Publicado 2020

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development

por Jacques, Samuel, van der Sloot, Almer M., C. Huard, Caroline, Coulombe-Huntington, Jasmin, Tsao, Sarah, Tollis, Sylvain, Bertomeu, Thierry, Culp, Elizabeth J., Pallant, Daniel, Cook, Michael A., Bonneil, Eric, Thibault, Pierre, Wright, Gerard D., Tyers, Mike
Publicado 2020

Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

por Becker, Pablo D., Legrand, Nicolas, van Geelen, Caroline M. M., Noerder, Miriam, Huntington, Nicholas D., Lim, Annick, Yasuda, Etsuko, Diehl, Sean A., Scheeren, Ferenc A., Ott, Michael, Weijer, Kees, Wedemeyer, Heiner, Di Santo, James P., Beaumont, Tim, Guzman, Carlos A., Spits, Hergen
Publicado 2010

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

por Eissmann, Moritz F., Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby, Brunnberg, Jamina, Poh, Ashleigh R., Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas D., Hibbs, Margaret L., Boussioutas, Alex, Grimbaldeston, Michele A., Buchert, Michael, O’Donoghue, Robert J. J., Masson, Frederick, Ernst, Matthias
Publicado 2019