G(i)- and G(s)-coupled GPCRs show different modes of G-protein binding

por Van Eps, Ned, Altenbach, Christian, Caro, Lydia N., Latorraca, Naomi R., Hollingsworth, Scott A., Dror, Ron O., Ernst, Oliver P., Hubbell, Wayne L.
Publicado 2018

Structure-based discovery of selective positive allosteric modulators of antagonists for the M(2) muscarinic acetylcholine receptor

por Korczynska, Magdalena, Clark, Mary J., Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R., Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C., Lyda, Brent R., May, Lauren T., Baltos, Jo-Anne, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur, Shoichet, Brian K., Sunahara, Roger K.
Publicado 2018

Revealing nascent proteomics in signaling pathways and cell differentiation

por Forester, Craig M., Zhao, Qian, Phillips, Nancy J., Urisman, Anatoly, Chalkley, Robert J., Oses-Prieto, Juan A., Zhang, Li, Ruggero, Davide, Burlingame, Alma L.
Publicado 2018

Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light

por Prasse, Carsten, Ford, Breanna, Nomura, Daniel K., Sedlak, David L.
Publicado 2018

Origins and genetic legacies of the Caribbean Taino

por Schroeder, Hannes, Sikora, Martin, Gopalakrishnan, Shyam, Cassidy, Lara M., Maisano Delser, Pierpaolo, Sandoval Velasco, Marcela, Schraiber, Joshua G., Rasmussen, Simon, Homburger, Julian R., Ávila-Arcos, María C., Allentoft, Morten E., Moreno-Mayar, J. Víctor, Renaud, Gabriel, Gómez-Carballa, Alberto, Laffoon, Jason E., Hopkins, Rachel J. A., Higham, Thomas F. G., Carr, Robert S., Schaffer, William C., Day, Jane S., Hoogland, Menno, Salas, Antonio, Bustamante, Carlos D., Nielsen, Rasmus, Bradley, Daniel G., Hofman, Corinne L., Willerslev, Eske
Publicado 2018

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120

por Yolitz, Jason, Schwing, Catherine, Chang, Julia, Van Ryk, Donald, Nawaz, Fatima, Wei, Danlan, Cicala, Claudia, Arthos, James, Fauci, Anthony S.
Publicado 2018

Fast flow-based algorithm for creating density-equalizing map projections

por Gastner, Michael T., Seguy, Vivien, More, Pratyush
Publicado 2018

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

por Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David
Publicado 2018

Tracking the route of molecular oxygen in O(2)-tolerant membrane-bound [NiFe] hydrogenase

por Kalms, Jacqueline, Schmidt, Andrea, Frielingsdorf, Stefan, Utesch, Tillmann, Gotthard, Guillaume, von Stetten, David, van der Linden, Peter, Royant, Antoine, Mroginski, Maria Andrea, Carpentier, Philippe, Lenz, Oliver, Scheerer, Patrick
Publicado 2018

Diagnostic utility of telomere length testing in a hospital-based setting

por Alder, Jonathan K., Hanumanthu, Vidya Sagar, Strong, Margaret A., DeZern, Amy E., Stanley, Susan E., Takemoto, Clifford M., Danilova, Ludmilla, Applegate, Carolyn D., Bolton, Stephen G., Mohr, David W., Brodsky, Robert A., Casella, James F., Greider, Carol W., Jackson, J. Brooks, Armanios, Mary
Publicado 2018

Defining the sizes of airborne particles that mediate influenza transmission in ferrets

por Zhou, Jie, Wei, Jianjian, Choy, Ka-Tim, Sia, Sin Fun, Rowlands, Dewi K., Yu, Dan, Wu, Chung-Yi, Lindsley, William G., Cowling, Benjamin J., McDevitt, James, Peiris, Malik, Li, Yuguo, Yen, Hui-Ling
Publicado 2018

Prospective forecasts of annual dengue hemorrhagic fever incidence in Thailand, 2010–2014

por Lauer, Stephen A., Sakrejda, Krzysztof, Ray, Evan L., Keegan, Lindsay T., Bi, Qifang, Suangtho, Paphanij, Hinjoy, Soawapak, Iamsirithaworn, Sopon, Suthachana, Suthanun, Laosiritaworn, Yongjua, Cummings, Derek A.T., Lessler, Justin, Reich, Nicholas G.
Publicado 2018

Rainfall statistics, stationarity, and climate change

por Sun, Fubao, Roderick, Michael L., Farquhar, Graham D.
Publicado 2018

Trophic redundancy reduces vulnerability to extinction cascades

por Sanders, Dirk, Thébault, Elisa, Kehoe, Rachel, Frank van Veen, F. J.
Publicado 2018

Fundamental limits on dynamic inference from single-cell snapshots

por Weinreb, Caleb, Wolock, Samuel, Tusi, Betsabeh K., Socolovsky, Merav, Klein, Allon M.
Publicado 2018

Transcriptome dynamics at Arabidopsis graft junctions reveal an intertissue recognition mechanism that activates vascular regeneration

por Melnyk, Charles W., Gabel, Alexander, Hardcastle, Thomas J., Robinson, Sarah, Miyashima, Shunsuke, Grosse, Ivo, Meyerowitz, Elliot M.
Publicado 2018

Contribution of NIH funding to new drug approvals 2010–2016

por Galkina Cleary, Ekaterina, Beierlein, Jennifer M., Khanuja, Navleen Surjit, McNamee, Laura M., Ledley, Fred D.
Publicado 2018

Stabilized supralinear network can give rise to bistable, oscillatory, and persistent activity

por Kraynyukova, Nataliya, Tchumatchenko, Tatjana
Publicado 2018

CD96 expression determines the inflammatory potential of IL-9–producing Th9 cells

por Stanko, Katarina, Iwert, Christina, Appelt, Christine, Vogt, Katrin, Schumann, Julia, Strunk, Franziska Janina, Ahrlich, Stefanie, Schlickeiser, Stephan, Romagnani, Chiara, Jürchott, Karsten, Meisel, Christian, Willimsky, Gerald, Kühl, Anja A., Sawitzki, Birgit
Publicado 2018

Adaptive diversification of growth allometry in the plant Arabidopsis thaliana

por Vasseur, François, Exposito-Alonso, Moises, Ayala-Garay, Oscar J., Wang, George, Enquist, Brian J., Vile, Denis, Violle, Cyrille, Weigel, Detlef
Publicado 2018