“…We consider four incentive options to incentivise research and development of new antibiotics, including subscription payments, market entry rewards, transferable exclusivity extensions, and milestone payments. …”
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“…Minimally invasive surgery represented a significant milestone in modern surgery; however, continuous innovation and the emergence of new technologies pose new challenges in terms of surgical learning curves since new interventions are associated with increased surgical complexity and a higher risk of complications. …”
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“…This is an important milestone for the HL-LHC project. The construction is needed for the new underground structures at Point 5 close to the largest underground particle accelerator in the world (Large Hadron Collider). …”
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“…After the first successful years of running at the LHC, the ATLAS Collaboration is preparing to fully exploit the unprecedented physics opportunities offered by exploration of a completely new energy domain. This program builds on the excellent LHC accelerator complex performance demonstrated to date. …”
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“…This operation, started on Tuesday Feb 28 when the first components of the new instrument were descended into the experiment’s cavern, is one of the most significant milestones ahead of the LHC restart this spring. …”
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“…KARL STORZ presents its new full HD camera platform IMAGE 1 SPIES(TM), a new milestone in endoscopic imaging. …”
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“…Across the years, being the backbone of numerous data management solutions used within the WLCG collaboration, the XRootD framework and protocol became one of the most important building blocks for storage solutions in the High Energy Physics (HEP) community. The latest big milestone for the project, release 5, introduced multitude of architectural improvements and functional enhancements, including the new client side declarative API, which is the main focus of this study. …”
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“…The epidermal growth factor tyrosine kinase inhibitors such as gefitinib, erlotinib, icotinib and anaplastic lymphoma kinase tyrosine kinase inhibitors crizotinib have brought a milestone advance. In recent years new generations of tyrosine kinase inhibitors have achieved a great success in patients with acquired resistance to the above two kinds of drugs. …”
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“…Advances in the area require the development of more efficient approaches to deconstruct plant materials, better exploitation of the catalytic potential of prokaryotes and lower eukaryotes and the identification of new and useful genes for product synthesis. Further research and progress is urgently needed in order for government and industry to achieve the major milestone of transitioning 30% of the total industry to renewable sources by 2050.…”
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“…Here it is sought to evaluate Brazil’s achievements towards reaching the WHO GTS milestone in 2030. Considering the total number of new malaria cases in 2015, the main research question is: will Brazil reach the malaria elimination goal in 2030? …”
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“…The COVID-19 pandemic represents a milestone in vaccine research and development in a global context. …”
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“…Here, we present the structure-guided development of high-affinity small molecules stabilizing p53-Y220C in vitro, along with the synthetic routes developed in the process, in vitro structure–activity relationship data, and confirmation of their binding mode by protein X-ray crystallography. We disclose two new chemical probes displaying sub-micromolar binding affinity in vitro, marking an important milestone since the discovery of the first small-molecule ligand of Y220C in 2008. …”
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“…The international study group on data preservation in High Energy Physics, DPHEP, achieved a major milestone in 2012 with the publication of its eagerly anticipated large-scale report [1]. …”
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“…--HTML-->Across the years, being the backbone of numerous data management solutions used within the WLCG collaboration, the XRootD framework and protocol became one of the most important building blocks for storage solutions in the High Energy Physics (HEP) community. The latest big milestone for the project, release 5, introduced multitude of architectural improvements and functional enhancements, including the new client side declarative API, which is the main focus of this study. …”
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“…Significance: The modern use of fluorescence in surgery came iteratively through new devices and pre-existing imaging agents, with indications that were paved via regulatory approvals and device clearances. …”
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“…Randomized clinical trials are considered the milestones of clinical research in oncology, and guided the development and approval of new compounds so far. …”
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“…The past evolutionary sequences provide leads for future evolutions. New courses and innovations are being designed and implemented to make pharmacology education more meaningful and useful to the new technology-savvy students. …”
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“…China’s foreign investment law regime has experienced significant changes in recent years. A milestone came with the passing of the Foreign Investment Law (FIL) in 2019, replacing the laws and regulations that had governed foreign investment in China for four decades. …”
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“…The St Petersburg declaration, signed in 1868, is a milestone in the history of warfare and humanitarian law, as it prohibits the use of explosive bullets, which are considered to cause unnecessary suffering. …”
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