“…We also propose considering new models that integrate biological age as a new pathway to improve precision drug dosing in older adults.…”
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“…Introduction of Rho kinase inhibitors with an entirely new mechanism of action from that of the currently used anti glaucoma medications has been a significant milestone. …”
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“…Since this is the first-ever demonstration of cold plasma inactivation of SARS-CoV-2, it is a significant milestone in the prevention and treatment of coronavirus disease 2019 (COVID-19) and presents a new opportunity for the scientific, engineering, and medical communities.…”
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“…The vaccine development to cease this COVID-19 pandemic sets a milestone for the pan-coronavirus vaccine’s designing and manufacturing. …”
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“…Strong government leadership, adequate funding, clear targets and timelines, management of conflict of interest, comprehensive monitoring and evaluation, and a plan for responsive regulation in the event of missed milestones will be required if the new Healthy Food Partnership is to achieve its urgent public health goals.…”
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“…Furthermore, this technology reached a new milestone in the energy-saving and efficiency-increasing performance of Taiwan's buses.…”
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“…ABSTRACT: A recent paradigm shift in the diagnostics of medulloblastoma allowed the distinction of four major groups defined by genetic data rather than histology. This new molecular classification correlates better with prognosis and will allow for the better clinical management of therapies targeting druggable mutations, but also offer a new combination of monitoring tumor development in real-time and treatment response by sequential liquid biopsy. …”
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“…Axon-dendrite formation is a crucial milestone in the life history of neurons. During this process, historically referred as “the establishment of polarity,” newborn neurons undergo biochemical, morphological and functional transformations to generate the axonal and dendritic domains, which are the basis of neuronal wiring and connectivity. …”
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“…New advances in directing the neuronal differentiation of human embryonic and induced pluripotent stem cells (hPSCs, abbreviation intended to convey both categories of pluripotent stem cells) have promoted the development of culture systems capable of modeling early neurogenesis and neural specification at some of their critical milestones. …”
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“…A timeline of important milestones during the evolution of surgical microscope is provided in this study. …”
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“…The implementation of trastuzumab in the treatment of HER2-positive advanced adenocarcinoma is a milestone as it marked the introduction of the first molecularly targeted treatment of gastric cancer. …”
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“…This book charts the milestones in the history of mathematics and computer science in a narrative timeline format. …”
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“…His work “Productive Thinking” (1945), written in New York, is regarded as a milestone in creativity research. …”
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“…Sequencing the human genome was a huge milestone in genetic research that revealed almost the total DNA sequence required to create a human being. …”
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“…Since the initial use of antitumor necrosis factor agents, a renaissance in our understanding of psoriasis has been underway, leading to the elucidation of the T-helper 17 (Th17) from the Th1 pathway. With each new treatment, the pathogenesis for psoriasis continues to be more defined, allowing for improved targeted therapies and the ability to achieve new milestones in efficacy.…”
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“…This paper reviews the main features of the new PS Personnel Protection System (PSPSS) as well as the main milestones for its deployment during the Long Shutdown of 2013-2014. …”
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“…Hopefully, recent advances involving the discovery of novel pockets on the RAS surface as well as highly specific small-molecule inhibitors able to block its interaction with effectors and/or activators may lead to the development of new, effective treatments for cancer. This review intends to provide a quick, summarized historical overview of the main milestones in RAS research spanning from the initial discovery of the viral RAS oncogenes in rodent tumors to the latest attempts at targeting RAS oncogenes in various human cancers.…”
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“…An important milestone for the AB/BI group during 2006 is the commissioning with beam of the CNGS facility at CERN. …”
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“…We identify ‘intragenic invertons’, a surprising new class of invertible elements found entirely within genes, in bacteria and archaea. …”
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