“…The discovery that major histocompatibility complex (MHC) class I-related molecule 1 (MR1) presents microbial antigens to mucosal-associated invariant T (MAIT) cells was a significant scientific milestone in the last decade. Surveillance for foreign metabolically derived antigens added a new class of target structures for immune recognition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The 2010 ACVIM Consensus Statement, including guidelines for the diagnostic criteria for canine and feline CIE, was an important milestone to a more standardized approach to patients suspected of a CIE diagnosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Measuring the top mass during and after the LHC commissioning is consequently one of the important milestones on the path to the dicovery of new physics.…”
Enlace del recurso

“…The objective of this study was to use OpERA methodology to undertake a retrospective analysis of the timelines associated with important components of the ANVISA regulatory review process to establish a baseline against which the influence of the new law could be measured. METHODS: The OpERA tool was used to collect specific milestone data that identify time periods, review stages, and data points for products approved by ANVISA 2013–2016. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Significant advances include an updated classification system, the description of alternative virus-like protein morphologies and capsid dynamics, and the further elucidation of the functions and roles of various viral proteins. Important milestones include new insights into cell tropism, host and microbial attachment factors and receptors, interactions with the cellular translational apparatus, and viral egress from cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This paper outlines alternative designs for a new trigger system and the consequences for cost, latency, complexity and flexibility. …”
Enlace del recurso
Enlace del recurso

“…In addition, the status of the firmware development and a summary of the main milestones achieved and the future plans will be presented.…”
Enlace del recurso

“…In addition, the status of the firmware development, a summary of the main milestones achieved and the future plans will be presented.…”
Enlace del recurso

“…The SPS Beam Dump Facility (BDF) being studied as part of the Physics Beyond Colliders (PBC) CERN project has recently reached an important milestone with the completion of the comprehensive feasibility study. …”
Enlace del recurso
Enlace del recurso

“…Recently, the development of novel oral anticoagulants (NOACs) that directly inhibit factor Xa or thrombin is a milestone achievement in the prevention and treatment of VTE. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this commentary, the authors ask for a pause in this debate to consider the implications of the student perspective as well as important trends in the medical education continuum that affect the senior student (e.g., milestones that will set new expectations for first-year residents, increasing pressure associated with matching to a residency). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The application of human induced pluripotent stem cells has greatly helped to advance our knowledge in this field and enabled to obtain numerous in vitro patient-specific cellular models useful to study the underlying molecular mechanisms and test new therapeutic strategies. A milestone in the research of genetically determined heart disease was the introduction of genomic technologies that provided unparalleled opportunities to explore the genetic architecture of cardiomyopathies, thanks to the generation of isogenic pairs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The High-Luminosity LHC (HL-LHC) will usher in a new era in high-energy physics. The HL-LHC experimental conditions entail an instantaneous luminosity of up to $7.5 \times 10^{34}$ cm$^{-2}$ s$^{-1}$ and up to 200 simultaneous collisions per bunch crossing (pileup). …”
Enlace del recurso
Enlace del recurso

“…Antipsychotic long-acting formulations (LAI-AP) have emerged as a new therapeutic choice to treat patients presenting a severe mental disorder. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After personal recollections from the early days of low-temperature detectors (LTD), we shall give a condensed overview of the milestones and achievements in their main applications. …”
Enlace del recurso
Enlace del recurso

“…Top quark physics is one of the milestones of the physics program of the ATLAS experiment at the Large Hadron Collider. …”
Enlace del recurso

“…All these milestones are described in this article.…”
Enlace del recurso

“…With secukinumab being the first in class to receive Food and Drug Administration approval, this article will further focus on this new biologic agent and review the milestones in its development and marketing.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Factors affecting sustainability included local leadership support, involvement of frontline clinicians, and sharing milestones to motivate continued QI. The INSPIRED QIC enabled teams across Canada to adapt and implement a new COPD care model for high users of health-care with rapid improvements to work practices, cultural change, and skill sets, and at relatively low cost.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In cerebral palsy (CP) learning of any new task is an extremely slow process due to damage in sensory and motor areas of brain affecting the cognitive ability of the child and putting constraints in achieving timely developmental milestones. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso